Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Henry Simpkins"'
Autor:
Erika Balfour MD, Robert Stallone BA, Joseph Castagnaro MS, Hannah Poczter MPH, Deborah Schron MD, James Martone BSMT, Dwayne Breining MD, Henry Simpkins MD, PhD, Tom Neglia BSMT, Paul Kalish MD, James M. Crawford MD, PhD
Publikováno v:
Academic Pathology, Vol 3 (2016)
From 2009 to 2015, the laboratories of the 19-hospital North Shore-LIJ Health System experienced 5 threatened interruptions in service and supported 2 regional health-care providers with threatened interruptions in their laboratory service. We report
Externí odkaz:
https://doaj.org/article/7746bebd8662484280d60ac930b49e3e
Autor:
Henry Simpkins, John Zihou Chen, Monika Wrzolek, Jianli Chen, Fiona Simpkins, Visitacion Pabicon, Rong Wu
Publikováno v:
American Journal of Biomedical and Life Sciences. 7:110
Dihydrodiol dehydrogenases (DDHs) belong to a superfamily of cytosolic NADP (H)-dependent oxidoreductases. The over-expression of DDHs induces cisplatin resistance. 2-Deoxy-D-glucose (2-DG), a glucose analogue, is currently being used as an anticance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efbfeedca798feca8f40ee7238ed77f9
https://doi.org/10.11648/j.ajbls.20190705.13
https://doi.org/10.11648/j.ajbls.20190705.13
Publikováno v:
Cancer chemotherapy and pharmacology. 79(2)
Nrf2 and its role in controlling levels of the AKR family of aldo–keto reductases which have been implicated in resistance to platinum-based chemotherapy was studied in ovarian, cervical and lung cell lines. Nrf2 shRNA knockdowns of cells from diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0211a34bc62e5e7d15818e8e1ed9c8
https://pubmed.ncbi.nlm.nih.gov/28120035
https://pubmed.ncbi.nlm.nih.gov/28120035
Autor:
Dwayne Breining, Henry Simpkins, James Martone, Tom Neglia, Joseph Castagnaro, Hannah Poczter, Erika Balfour, Robert Stallone, Deborah Schron, Paul Kalish, James M. Crawford
Publikováno v:
Academic Pathology, Vol 3 (2016)
Academic Pathology
Academic Pathology
From 2009 to 2015, the laboratories of the 19-hospital North Shore-LIJ Health System experienced 5 threatened interruptions in service and supported 2 regional health-care providers with threatened interruptions in their laboratory service. We report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e38d33eff211034537f093349e83a9
https://doaj.org/article/7746bebd8662484280d60ac930b49e3e
https://doaj.org/article/7746bebd8662484280d60ac930b49e3e
Publikováno v:
Journal of Biological Chemistry. 277:15035-15043
We employed cDNA microarrays to identify the differentially expressed genes in a cisplatin-sensitive parental (2008) human ovarian carcinoma cell line and its cisplatin-resistant variant (2008/C13*). Differential expression of five genes was found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc229dc7dec6d30276350175387a49c
https://doi.org/10.1074/jbc.m112028200
https://doi.org/10.1074/jbc.m112028200
Publikováno v:
Biochemical Pharmacology. 63:1149-1158
Paclitaxel, an antimitotic, anticancer agent, induces cell cycle arrest in the mitotic phase by binding to the beta-tubulin subunit and forming highly stable microtubule polymers that resist depolymerization. The overexpression of the P-glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f26a05867ddc6be71c221226fcc3891
https://doi.org/10.1016/s0006-2952(02)00850-x
https://doi.org/10.1016/s0006-2952(02)00850-x
Autor:
Arthur S. Miller, Henry Simpkins, Jotica Talwar, Robert A Christman, Charalambos C. Solomides
Publikováno v:
Human Pathology. 33:153-157
The purpose of this study was to determine the histologic class and immunologic phenotype of lymphomas presenting initially in the oral cavity and whether this correlated to a high incidence of Epstein-Barr virus (EBV) infection as has been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c669b9f786ee147c81e4e5032d78bacf
https://doi.org/10.1053/hupa.2002.30721
https://doi.org/10.1053/hupa.2002.30721
Publikováno v:
Cancer chemotherapy and pharmacology. 75(6)
This study was performed to determine whether or not in cervical, ovarian and lung cancer cell lines, free radicals (ROS) play a role in cisplatin cytotoxicity and activation of the mitochondrial and JNK/p38 pathways. The role of the enzyme, dihydrod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cfbc09306211c0bff5b3aa36f6168d
https://pubmed.ncbi.nlm.nih.gov/25894720
https://pubmed.ncbi.nlm.nih.gov/25894720
Publikováno v:
Biochemical and biophysical research communications. 447(1)
It is predicted that the incidence of mesothelioma will increase and thus it is important to find new ways to treat this chemoresistant tumor. Glutathione-S-Transferase π (GSTπ) is found at significant levels in mesotheliomas and thus attenuating i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe016f9bf41145928ef3f0413dd041d8
https://pubmed.ncbi.nlm.nih.gov/24690178
https://pubmed.ncbi.nlm.nih.gov/24690178
Autor:
Henry Simpkins, Robert M. Evans
Publikováno v:
Experimental Cell Research. 245:69-78
Cisplatin has acute but reversible effects on the organization of the intermediate filament component of the cytoskeleton as well as the mitochondrial function of cultured 3T3 cells. These effects do not involve major changes in total cell or cytoske
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31a5e8be84a7d1a16e693c532b0aa73
https://doi.org/10.1006/excr.1998.4250
https://doi.org/10.1006/excr.1998.4250