Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Henry S. Cheng"'
Autor:
Henry S. Cheng, Daniel Pérez-Cremades, Rulin Zhuang, Anurag Jamaiyar, Winona Wu, Jingshu Chen, Aspasia Tzani, Lauren Stone, Jorge Plutzky, Terence E. Ryan, Philip P. Goodney, Mark A. Creager, Marc S. Sabatine, Marc P. Bonaca, Mark W. Feinberg
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Patients with peripheral artery disease (PAD) and diabetes compose a high-risk population for development of critical limb ischemia (CLI) and amputation, although the underlying mechanisms remain poorly understood. Comparison of dysregulated microRNA
Externí odkaz:
https://doaj.org/article/3e5659fa89f24a509170d7bf63c2bd7c
A miRNA/CXCR4 signaling axis impairs monopoiesis and angiogenesis in diabetic critical limb ischemia
Autor:
Henry S. Cheng, Rulin Zhuang, Daniel Pérez-Cremades, Jingshu Chen, Anurag Jamaiyar, Winona Wu, Grasiele Sausen, Aspasia Tzani, Jorge Plutzky, Jorge Henao-Mejia, Philip P. Goodney, Mark A. Creager, Marc S. Sabatine, Marc P. Bonaca, Mark W. Feinberg
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Patients with peripheral artery disease (PAD) and diabetes have the highest risk of critical limb ischemia (CLI) and amputation, yet the underlying mechanisms remain incompletely understood. MicroRNA (miRNA) sequencing of plasma from diabetic patient
Externí odkaz:
https://doaj.org/article/f2fe1fa1dd814c8fbc8a3dcf4c6f5b75
Autor:
Shawn Veitch, Makon-Sébastien Njock, Mark Chandy, M. Ahsan Siraj, Lijun Chi, HaoQi Mak, Kai Yu, Kumaragurubaran Rathnakumar, Carmina Anjelica Perez-Romero, Zhiqi Chen, Faisal J. Alibhai, Dakota Gustafson, Sneha Raju, Ruilin Wu, Dorrin Zarrin Khat, Yaxu Wang, Amalia Caballero, Patrick Meagher, Edward Lau, Lejla Pepic, Henry S. Cheng, Natalie J. Galant, Kathryn L. Howe, Ren-Ke Li, Kim A. Connelly, Mansoor Husain, Paul Delgado-Olguin, Jason E. Fish
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-18 (2022)
Abstract Background Type 2 diabetes (T2D) is associated with coronary microvascular dysfunction, which is thought to contribute to compromised diastolic function, ultimately culminating in heart failure with preserved ejection fraction (HFpEF). The m
Externí odkaz:
https://doaj.org/article/e37a62f1aeef4228a5e6790679b5f01c
Autor:
Sunil K. Saini, Daniel Pérez‐Cremades, Henry S. Cheng, Kate Kosmac, Charlotte A Peterson, Lingyu Li, Lu Tian, Gengfu Dong, Kevin K. Wu, Brian Bouverat, Stephanie E. Wohlgemuth, Terence Ryan, Robert L. Sufit, Luigi Ferrucci, Mary M. McDermott, Christiaan Leeuwenburgh, Mark W. Feinberg
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 21 (2022)
Background Peripheral artery disease (PAD) is associated with gastrocnemius muscle abnormalities. However, the biological pathways associated with gastrocnemius muscle dysfunction and their associations with progression of PAD are largely unknown. Th
Externí odkaz:
https://doaj.org/article/21587088378c47698ffa4d8ba378fcb0
Autor:
Tharini Sivasubramaniyam, Jiaqi Yang, Henry S. Cheng, Alexandra Zyla, Angela Li, Rickvinder Besla, Idit Dotan, Xavier S. Revelo, Sally Yu Shi, Helen Le, Stephanie A. Schroer, David W. Dodington, Yoo Jin Park, Min Jeong Kim, Daniella Febbraro, Isabelle Ruel, Jacques Genest, Raymond H. Kim, Tak W. Mak, Daniel A. Winer, Clinton S. Robbins, Minna Woo
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Inflammation is a key contributor to atherosclerosis with macrophages playing a pivotal role through the induction of oxidative stress and cytokine/chemokine secretion. DJ1, an anti-oxidant protein, has shown to paradoxically protect against
Externí odkaz:
https://doaj.org/article/dd1b0c94e3934c83829b8e94c00d30fc
Autor:
David A. Gross, Henry S. Cheng, Rulin Zhuang, Michael G. McCoy, Daniel Pérez-Cremades, Zachary Salyers, A.K.M. Khyrul Wara, Stefan Haemmig, Terence E. Ryan, Mark W. Feinberg
Publikováno v:
JCI Insight, Vol 7, Iss 1 (2022)
SNHG12, a long noncoding RNA (lncRNA) dysregulated in atherosclerosis, is known to be a key regulator of vascular senescence in endothelial cells (ECs). However, its role in angiogenesis and peripheral artery disease has not been elucidated. Hind-lim
Externí odkaz:
https://doaj.org/article/2959e62ce2ee4472a7e604a09902ea61
Autor:
Kevin R. Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, Andrea L. Conroy, Michael Hawkes, Henry S. Cheng, Makon-Sébastien Njock, Jason E. Fish, John M. Harlan, Jose A. López, W. Conrad Liles, Kevin C. Kain
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 24-33 (2017)
Abstract miR-155 has been shown to participate in host response to infection and neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell function. We hypothesized that miR-155 may contribute to the pathogenesis of
Externí odkaz:
https://doaj.org/article/56bbf8fe6dc4421fa32a5aa6aa24e667
Publikováno v:
JVS - Vascular Science, Vol 1, Iss , Pp 257-258 (2020)
Externí odkaz:
https://doaj.org/article/cc1ba5aa14404f0ba903e3644c1cf7a7
Autor:
Eric A. Shikatani, Rickvinder Besla, Sherine Ensan, Aditi Upadhye, Nadiya Khyzha, Angela Li, Takuo Emoto, Felix Chiu, Norbert Degousee, Joshua M. Moreau, Heather M. Perry, Danya Thayaparan, Henry S. Cheng, Shaun Pacheco, David Smyth, Hossein Noyan, Caleb C.J. Zavitz, Carla M.T. Bauer, Ingo Hilgendorf, Peter Libby, Filip K. Swirski, Jennifer L. Gommerman, Jason E. Fish, Martin R. Stampfli, Myron I. Cybulsky, Barry B. Rubin, Christopher J. Paige, Timothy P. Bender, Coleen A. McNamara, Mansoor Husain, Clinton S. Robbins
Publikováno v:
Cell Reports, Vol 27, Iss 8, Pp 2304-2312.e6 (2019)
Summary: Mechanisms that govern transcriptional regulation of inflammation in atherosclerosis remain largely unknown. Here, we identify the nuclear transcription factor c-Myb as an important mediator of atherosclerotic disease in mice. Atherosclerosi
Externí odkaz:
https://doaj.org/article/739dd39d1f244a6f8144a50e8b09c4c0
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
Cardiovascular diseases such as atherosclerosis are one of the leading causes of morbidity and mortality worldwide. The clinical manifestations of atherosclerosis, which include heart attack and stroke, occur several decades after initiation of the d
Externí odkaz:
https://doaj.org/article/8612bb268593419893b65f0e6998ee8c