First-in-Human Controlled Exposure to Inhaled Graphene Oxide

Autor: Andrews, Jack, Joshi, Shruti, Tzolos, Evangelos, Syed, Maaz, Cuthbert, Hayley, Crica, Livia, Lozano, Neus, Raftis, Jennifer, Bruce, Lorraine, Poland, Craig, Duffin, Rodger, Fokkens, Paul, Leseman, Daan, Boere, John, Megson, Ian, Whitfield, Phillip, Okwelogu, Emmanuel, Hadjidemetriou, Marilena, Bussy, Cyrill, Cassee, Flemming, Newby, David, Kostarelos, Kostas, Miller, Mark

Publikováno v: Andrews, J, Joshi, S, Tzolos, E, Syed, M, Cuthbert, H, Crica, L, Lozano, N, Raftis, J, Bruce, L, Poland, C, Duffin, R, Fokkens, P, Leseman, D, Boere, J, Megson, I, Whitfield, P, Okwelogu, E, Hadjidemetriou, M, Bussy, C, Cassee, F, Newby, D, Kostarelos, K & Miller, M 2023, First-in-Human Controlled Exposure to Inhaled Graphene Oxide . in Annals of Work Exposures and Health . s1 edn, vol. 67, pp. i52-i53, Inhaled Particles and NanOEH Conference 2023, Manchester, United Kingdom, 15/05/23 . https://doi.org/10.1093/annweh/wxac087.128

Graphene oxide nanomaterials have been developed for wide-ranging applications, but has potential safety concerns for human health. Controlled inhalation exposures in human volunteers have been a vital means to determine the effects and mechanisms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::5542425d399d849535d553f8496ac2fb
https://research.manchester.ac.uk/en/publications/d3d0f1e3-7af5-4498-882c-6d36451573c4

Evaluation of the Toxicity, Alveolar Cell Accumulation and Clearance of PET and PS Nanoplastics in Mouse Lungs

Autor: Loret, Thomas, Holme, Sonja, Kuttykattil, Aswin, Villacorta, Aliro, Rodríguez-Garraus, Adriana, Venus, Tom, Estrela-Lopis, Irina, Catalan, Julia, Marcos, Ricard, Hernandez, Alba, Bussy, Cyrill

Publikováno v: Loret, T, Holme, S, Kuttykattil, A, Villacorta, A, Rodríguez-Garraus, A, Venus, T, Estrela-Lopis, I, Catalan, J, Marcos, R, Hernandez, A & Bussy, C 2023, Evaluation of the Toxicity, Alveolar Cell Accumulation and Clearance of PET and PS Nanoplastics in Mouse Lungs . in Annals of Work Exposures and Health . vol. 67, pp. i53-i54, Inhaled Particles and NanOEH Conference 2023, Manchester, United Kingdom, 15/05/23 . https://doi.org/10.1093/annweh/wxac087.130

Airborne micro and nano-plastics (MNPs) have been detected in both indoor and outdoor settings, raising concerns about potential adverse effects upon inhalation. Yet, their potential pulmonary toxicity has not been studied extensively. Herein, we eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::8804c3d5cbc6281ca9c081dcb05ae35f
https://doi.org/10.1093/annweh/wxac087.130

Quantification of hard X‐ray photoelectron spectroscopy: Calculating relative sensitivity factors for 1.5‐ to 10‐keV photons in any instrument geometry

Autor: David J. H. Cant, Ben F. Spencer, Wendy R. Flavell, Alexander G. Shard

Publikováno v: Cant, D J H, Spencer, B F, Flavell, W R & Shard, A G 2022, ' Quantification of hard X-ray photoelectron spectroscopy: Calculating relative sensitivity factors for 1.5- to 10-keV photons in any instrument geometry ', Surface and Interface Analysis . https://doi.org/10.1002/sia.7059

A method for the rapid determination of theoretical relative sensitivity factors (RSFs) for hard X-ray photoelectron spectroscopy (HAXPES) instruments of any type and photon energy has been developed. We develop empirical functions to describe discre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69611582d6c1dde14e553e2382ec8b7d
https://doi.org/10.1002/sia.7059

Modular synthesis of unsymmetrical [1]benzothieno[3,2-b][1]benzothiophene molecular semiconductors for organic transistors†

Autor: Masanori Tayu, David J. Procter, Michael L. Turner, Raymundo Marcial-Hernandez, Yurachat Janpatompong, Yuan Shen, Daniel J. Tate, Suphaluk Aphichatpanichakul, Raja U. Khan, Aiman Rahmanudin, Gregory J. P. Perry, Inigo Vitorica-Yrzebal, Ingo Dierking, Adibah Zamhuri

Publikováno v: Chemical Science
Tayu, M, Rahmanudin, A, Perry, G J P, Khan, R U, Tate, D J, Marcial-Hernandez, R, Shen, Y, Dierking, I, Janpatompong, Y, Aphichatpanichakul, S, Zamhuri, A, Victoria-Yrezabal, I, Turner, M L & Procter, D J 2021, ' Modular synthesis of unsymmetrical [1]benzothieno[3,2-b][1]benzothiophene molecular semiconductors for organic transistors ', Chemical Science, vol. 13, no. 2, pp. 421-429 . https://doi.org/10.1039/d1sc05070b

A modular approach to underexplored, unsymmetrical [1]benzothieno[3,2-b][1]benzothiophene (BTBT) scaffolds delivers a library of BTBT materials from readily available coupling partners by combining a transition-metal free Pummerer CH–CH-type cross-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de45a26fac9406f42ce9776470743416
http://europepmc.org/articles/PMC8730195

Graphene oxide modulates dendritic cell ability to promote T cell activation and cytokine production

Autor: Helen Parker, Alfredo Maria Gravagnuolo, Sandra Vranic, Livia Elena Crica, Leon Newman, Oliver Carnell, Cyrill Bussy, Rebecca S. Dookie, Eric Prestat, Sarah J. Haigh, Neus Lozano, Kostas Kostarelos, Andrew S. MacDonald

Publikováno v: Parker, H, Gravagnuolo, A M, Vranic, S, Crica, L E, Newman, L, Carnell, O, Bussy, C, Dookie, R S, Prestat, E, Haigh, S J, Lozano, N, Kostarelos, K & MacDonald, A S 2022, ' Graphene oxide modulates dendritic cell ability to promote T cell activation and cytokine production ', Nanoscale, vol. 14, no. 46, pp. 17297-17314 . https://doi.org/10.1039/d2nr02169b

An important aspect of immunotherapy is the ability of dendritic cells (DCs) to prime T cell immunity, an approach that has yielded promising results in some early phase clinical trials. However, novel approaches are required to improve DC therapeuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47eabdaa2e9cf8348085741dfc8754a3
https://pubmed.ncbi.nlm.nih.gov/36374249