Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Henry R. Kilgore"'
Autor:
Alessandra Dall’Agnese, Jesse M. Platt, Ming M. Zheng, Max Friesen, Giuseppe Dall’Agnese, Alyssa M. Blaise, Jessica B. Spinelli, Jonathan E. Henninger, Erin N. Tevonian, Nancy M. Hannett, Charalampos Lazaris, Hannah K. Drescher, Lea M. Bartsch, Henry R. Kilgore, Rudolf Jaenisch, Linda G. Griffith, Ibrahim I. Cisse, Jacob F. Jeppesen, Tong I. Lee, Richard A. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The authors find that the insulin receptor forms dynamic clusters during insulin signaling and that these clusters become dysfunctional in insulin resistance. This dysfunction is partially rescued by metformin, a drug used to treat type 2 diabetes.
Externí odkaz:
https://doaj.org/article/b6a27a393d354ad08dc4d2e2cdc0f034
Autor:
Amirah S. Mat Lani, Henry R. Kilgore, Yun Hu, Jennifer M. Schomaker, Jessica M. Roberts, Ronald T. Raines
Publikováno v:
J Am Chem Soc
Interest in mutually exclusive pairs of bioorthogonal labeling reagents continues to drive the design of new compounds that are capable of fast and predictable reactions. The ability to easily modify S-, N-, and O-containing cyclooctynes (SNO-OCTs) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f347b7ac8cd91ad582f46c22b8a6568
https://doi.org/10.1021/jacs.0c06725
https://doi.org/10.1021/jacs.0c06725
Autor:
Henry R. Kilgore, Richard A. Young
Publikováno v:
Nat Chem Biol
Biomolecular condensates compartmentalize and regulate assemblies of biomolecules engaged in vital physiological processes in cells. Specific proteins and nucleic acids engaged in shared functions occur in any one kind of condensate, suggesting that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee730d0e862630c2d4e03a160ebecee5
https://pubmed.ncbi.nlm.nih.gov/35761089
https://pubmed.ncbi.nlm.nih.gov/35761089
Autor:
Ronald T. Raines, Henry R. Kilgore
Publikováno v:
J Phys Chem B
Bonds between sulfur atoms are prevalent in natural products, peptides, and proteins. Disulfide bonds have a distinct chromophore. The wavelength of their maximal absorbance varies widely, from 250 to 500 nm. Here, we demonstrate that this wavelength
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8122ae8d1992ccad0525a46b96228627
https://europepmc.org/articles/PMC7293578/
https://europepmc.org/articles/PMC7293578/
Publikováno v:
PMC
Journal of the American Chemical Society, vol 142, iss 35
J Am Chem Soc
Journal of the American Chemical Society, vol 142, iss 35
J Am Chem Soc
Copyright © 2020 American Chemical Society. Epithiodiketopiperazines (ETPs) are a structurally complex class of fungal natural products with potent anticancer activity. In ETPs, the diketopiperazine ring is spanned by a disulfide bond that is constr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3151027b0ff7658a154fb128b970e9bc
https://hdl.handle.net/1721.1/136169
https://hdl.handle.net/1721.1/136169
Publikováno v:
PMC
Biochemistry
Biochemistry
Copyright © 2020 American Chemical Society. Glycosylation is a common modification that can endow proteins with altered physical and biological properties. Ribonuclease 1 (RNase 1), which is the human homologue of the archetypal enzyme RNase A, unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a722e4c962c5b15200305c42c242c7
https://hdl.handle.net/1721.1/132605
https://hdl.handle.net/1721.1/132605
Publikováno v:
Bioconjugate Chemistry. 29:1942-1949
Dextrans are a versatile class of polysaccharides with applications that span medicine, cell biology, food science, and consumer goods. Here, we report on a new type of large monofunctionalized dextran that exhibits unusual properties: efficient cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc01b6b952a53ce47ea556cba9ba9ef1
https://doi.org/10.1021/acs.bioconjchem.8b00198
https://doi.org/10.1021/acs.bioconjchem.8b00198
Publikováno v:
The FASEB Journal. 33
Dextrans have proven to be a widely useful class of polysaccharides, with applications ranging from antithrombotic agents to enhancers of vaccine stability. We have examined an unprecedented proper...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60eb7ba287bedf955709d69040c2a521
https://doi.org/10.1096/fasebj.2019.33.1_supplement.634.7
https://doi.org/10.1096/fasebj.2019.33.1_supplement.634.7
Autor:
Henry R. Kilgore, Ronald T. Raines
Publikováno v:
Journal of the American Chemical Society. 140(50)
Noncovalent interactions are ubiquitous in biology, taking on roles that include stabilizing the conformation of and assembling biomolecules, and providing an optimal environment for enzymatic catalysis. Here, we describe a noncovalent interaction th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf8989a99d3e66d73e3bfcc2754feb3
https://pubmed.ncbi.nlm.nih.gov/30403347
https://pubmed.ncbi.nlm.nih.gov/30403347
Publikováno v:
The Journal of organic chemistry. 82(8)
Fluorogenic probes are invaluable tools for spatiotemporal investigations within live cells. In common fluorogenic probes, the intrinsic fluorescence of a small-molecule fluorophore is masked by esterification until entry into a cell, where endogenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6091b145ff6ba7d243b9a1f4568346
https://pubmed.ncbi.nlm.nih.gov/28345343
https://pubmed.ncbi.nlm.nih.gov/28345343