Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Henry R. Bourne"'
Autor:
Henry R Bourne
Publikováno v:
eLife, Vol 2 (2013)
The relentless expansion that threatens the sustainability of biomedical research in the US takes a heavy toll on young researchers.
Externí odkaz:
https://doaj.org/article/45e3ecb6d5af4b6389e70f6f56d4e3e0
Autor:
Henry R Bourne
Publikováno v:
eLife, Vol 2 (2013)
Biomedical research in the US will become unsustainable unless scientists and research institutions start to question certain assumptions they have long taken for granted.
Externí odkaz:
https://doaj.org/article/122e0dd393c5434fbc869895d5137d97
Autor:
Henry R Bourne
Publikováno v:
eLife, Vol 2 (2013)
The biomedical research enterprise in the US has become unsustainable and urgent action is needed to address a variety of problems, including a lack of innovation, an over-reliance on soft money for faculty salaries, the use of graduate students as a
Externí odkaz:
https://doaj.org/article/1f5d79871cd94e058f6b04d7b4b8082c
Autor:
Orion D Weiner, Maike C Rentel, Alex Ott, Glenn E Brown, Mark Jedrychowski, Michael B Yaffe, Steven P Gygi, Lewis C Cantley, Henry R Bourne, Marc W Kirschner
Publikováno v:
PLoS Biology, Vol 4, Iss 2, p e38 (2006)
Migrating cells need to make different actin assemblies at the cell's leading and trailing edges and to maintain physical separation of signals for these assemblies. This asymmetric control of activities represents one important form of cell polarity
Externí odkaz:
https://doaj.org/article/308520e224e6496097abd9e9163ffe19
Autor:
Henry R. Bourne
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(35)
Academic biomedical science has had both a long boom in its funding and a subsequent scary bust. From 1970 to 1999, NIH budgets increased 9% per year (1); from 2000 to 2004, they doubled (2, 3). In 2005 came the unmistakable bust: flat-lined NIH budg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4324b79c2e50c54635f46700e908eb6e
https://pubmed.ncbi.nlm.nih.gov/30154238
https://pubmed.ncbi.nlm.nih.gov/30154238
Autor:
Henry R. Bourne
Publikováno v:
Proceedings of the National Academy of Sciences. 113:3414-3416
Alfred Gilman died on December 23, 2015, at age 74. With Martin Rodbell, he shared the 1994 Nobel Prize in Physiology or Medicine for discovering the first heterotrimeric guanine-nucleotide-binding (G-) protein and for elucidating the best-understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29402b9247bfd19cd1c4a965edb5a08
https://doi.org/10.1073/pnas.1602386113
https://doi.org/10.1073/pnas.1602386113
Autor:
Henry R. Bourne, Eric Vermillion
Decreasing federal and state support threaten long-term sustainability of research in publicly supported academic health centers. In weathering these financial threats, research at the University of California, San Francisco (UCSF) has undergone subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6046e83a4ae85029301a11dabc8b9599
https://doi.org/10.1101/071860
https://doi.org/10.1101/071860
Autor:
Hana El-Samad, Kit Wong, Fei Wang, Alex Groisman, Paul Herzmark, Kyle Campbell, Henry R. Bourne
Publikováno v:
Proceedings of the National Academy of Sciences. 104:13349-13354
We have analyzed chemotaxis of neutrophil-differentiated HL60 cells in microfluidic devices that create exponential gradients of the chemoattractant, f-Met-Leu-Phe (fMLP). Such gradients expose each cell to a difference in fMLP concentration (ΔC) ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef1a3feb32b2bc4e88c49f9fa0ef114
https://doi.org/10.1073/pnas.0705889104
https://doi.org/10.1073/pnas.0705889104
Autor:
Henry R. Bourne
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a75d3a8e40607e199b4d39b9086daad
https://pubmed.ncbi.nlm.nih.gov/25649813
https://pubmed.ncbi.nlm.nih.gov/25649813
Autor:
Supriya Srinivasan, Henry R. Bourne, Klaus Aktories, Daniel Kalman, Fred Hofmann, Fei Wang, Alexander Ott, Suzana Glavas
Publikováno v:
The Journal of Cell Biology
The Journal of cell biology, vol 160, iss 3
The Journal of cell biology, vol 160, iss 3
Neutrophils exposed to chemoattractants polarize and accumulate polymerized actin at the leading edge. In neutrophil-like HL-60 cells, this asymmetry depends on a positive feedback loop in which accumulation of a membrane lipid, phosphatidylinositol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9163ecff208f0dfb2985b678add64e
http://europepmc.org/articles/PMC2172671
http://europepmc.org/articles/PMC2172671