Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Henry Q. Zhang"'
Autor:
Peter F. Bousquet, Daniel H. Albert, Gary A. Gintant, Patrick A. Marcotte, Gilbert Diaz, George A. Cunha, Ruth L. Martin, Kathryn Houseman, Stevan W. Djuric, Jürgen Dinges, Jennifer J. Bouska, Thomas J. Sowin, Paul Tapang, Charles W. Hutchins, Michael R. Michaelides, Kimba L. Ashworth, Eric F. Johnson, Henry Q. Zhang, Irini Akritopoulou-Zanze, Michelle Nyein, Arnold Lee D, Hu Li, Steven K. Davidsen, Alan F. Gasiecki, Christopher M. Harris, Vijaya Gracias, Zhi Su, Zhiren Xia
Publikováno v:
Journal of Medicinal Chemistry. 50:2011-2029
The synthesis of a novel series of 1,4-dihydroindeno[1,2-c]pyrazoles with acetylene-type side chains is described. Optimization of those compounds as KDR kinase inhibitors identified 8, which displayed an oral activity in an estradiol-induced murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7224e585fce7d1645dd21a1f5e3e55
https://doi.org/10.1021/jm061223o
https://doi.org/10.1021/jm061223o
Autor:
Jürgen, Dinges, Kimba L, Ashworth, Irini, Akritopoulou-Zanze, Irini, Akritopolou-Zanze, Lee D, Arnold, Steven A, Baumeister, Peter F, Bousquet, George A, Cunha, Steven K, Davidsen, Stevan W, Djuric, Vijaya J, Gracias, Michael R, Michaelides, Paul, Rafferty, Thomas J, Sowin, Kent D, Stewart, Zhiren, Xia, Henry Q, Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4266-4271
A series of 1,4-dihydroindeno[1,2-c]pyrazoles with a 3-thiophene substituent carrying a urea-type side chain were identified as potent multitargeted (VEGFR and PDGFR families) receptor tyrosine kinase inhibitors. A KDR homology model suggested that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28684c9797329826d7cfb032e78b7827
https://doi.org/10.1016/j.bmcl.2006.05.066
https://doi.org/10.1016/j.bmcl.2006.05.066
Autor:
Richard B. van Breemen, Robert P. Dixon, Michael A. Marletta, Richard B. Silverman, Henry Q. Zhang, Dejan Nikolic
Publikováno v:
Journal of the American Chemical Society. 119:10888-10902
Nω-Allyl-l-arginine is shown to be a competitive reversible inhibitor and time-dependent inactivator of bovine brain nitric oxide synthase (nNOS). The enzyme is protected against inactivation by the presence of the substrate, the absence of O2, or i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd775c5dadf9868f4b3ae41ea0179961
https://doi.org/10.1021/ja964160f
https://doi.org/10.1021/ja964160f
Publikováno v:
Tetrahedron Letters. 44:8661-8663
Horner–Emmons reaction of phosphonate amides with aldehydes leads to generation of o -substituted aryl-acrylamides. These compounds have been shown to be useful to quickly establish structure–activity relationships (SAR) for soluble guanylyl cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9c16c324b05224dde35277bc42d7068
https://doi.org/10.1016/j.tetlet.2003.09.161
https://doi.org/10.1016/j.tetlet.2003.09.161
Publikováno v:
ChemInform. 37
An efficient method for the synthesis of 2-arylaminopyrimidines via microwave assisted, Pd-mediated amination of 2-chloropyrimidine is reported. This method is superior to the classical heating process, particularly when one of starting materials is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8361b7d7dbd28abe24de810bf1f17cfe
https://doi.org/10.1002/chin.200643172
https://doi.org/10.1002/chin.200643172
Autor:
Irini Akritopoulou-Zanze, Michael R. Michaelides, Arnold Lee D, Henry Q. Zhang, George A. Cunha, Thomas J. Sowin, Jürgen Dinges, Paul Rafferty, Kathleen M. Phelan, Nobuo Ogawa, Kent D. Stewart, Peter F. Bousquet, Teresa Barlozzari, Zhiren Xia, Ryukou Tokuyama, Nobuhiko Iwasaki, Anna M. Ericsson
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(16)
A series of 1,4-dihydroindeno[1,2-c]pyrazoles was prepared and evaluated for their enzymatic inhibition of KDR kinase. Computer modeling studies revealed the importance of attaching a basic side chain in predicting the binding mode of those compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc4f6d5601a0ddca4a0d92a0cf330bf
https://pubmed.ncbi.nlm.nih.gov/16750628
https://pubmed.ncbi.nlm.nih.gov/16750628
Publikováno v:
ChemInform. 35
Horner–Emmons reaction of phosphonate amides with aldehydes leads to generation of o -substituted aryl-acrylamides. These compounds have been shown to be useful to quickly establish structure–activity relationships (SAR) for soluble guanylyl cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25216109e1d11280585348a194a8a06f
https://doi.org/10.1002/chin.200410089
https://doi.org/10.1002/chin.200410089
Publikováno v:
ChemInform. 34
A short and versatile synthesis of substituted quinolines is provided. Alkylation of sodium tolylsulfinate with bromomethyl- or chloromethyl ketones generates beta-keto sulfones. Knoevenagel condensation of the beta-keto sulfones with an aldehyde pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3f19c64b0af1b8993864e72d73dec5
https://doi.org/10.1002/chin.200320161
https://doi.org/10.1002/chin.200320161
Autor:
Steven K. Davidsen, George A. Cunha, Henry Q. Zhang, Jürgen Dinges, Michael R. Michaelides, Lee D. Arnold, Vijaya Gracias, Zhiren Xia, Peter F. Bousquet, Paul Rafferty, Stevan W. Djuric, Steven A. Baumeister, Kent D. Stewart, Irini Akritopoulou-Zanze, Thomas J. Sowin, Kimba L. Ashworth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3516
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e1901913aa21b31cb30db679e0630cf
https://doi.org/10.1016/j.bmcl.2007.05.001
https://doi.org/10.1016/j.bmcl.2007.05.001
Publikováno v:
Journal of Medicinal Chemistry. 40:3869-3870
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066bfe76ca0a1990516caa2446728975
https://doi.org/10.1021/jm970550g
https://doi.org/10.1021/jm970550g