Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Henry N. Higgs"'
INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury
Autor:
Barbara Calabrese, Steven L. Jones, Yoko Shiraishi-Yamaguchi, Michael Lingelbach, Uri Manor, Tatyana M. Svitkina, Henry N. Higgs, Andy Y. Shih, Shelley Halpain
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Post injury cytoskeletal modifications in neurons are not fully understood. Here the authors describe a pro-survival actin cytoskeletal reorganization in neurons triggered during a model of ischemic stroke.
Externí odkaz:
https://doaj.org/article/e90bdbb4354e4126b7538ddf3eccdbce
Autor:
Taylor C. Harned, Radu V. Stan, Ze Cao, Rajarshi Chakrabarti, Henry N. Higgs, Catherine C. Y. Chang, Ta Yuan Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5525 (2023)
Cholesterol is a key component of all mammalian cell membranes. Disruptions in cholesterol metabolism have been observed in the context of various diseases, including neurodegenerative disorders such as Alzheimer’s disease (AD). The genetic and pha
Externí odkaz:
https://doaj.org/article/5caa6aa440cf4cbe8ec2bc52f2f180ce
Publikováno v:
Curr Biol
Actin filaments play multiple roles in the secretory pathway and endosome dynamics in mammals, including maintenance of Golgi structure, release of membrane cargo from the trans-Golgi network (TGN), endocytosis, and endosomal sorting dynamics. In add
Autor:
Pauline Wales, Christian E Schuberth, Roland Aufschnaiter, Johannes Fels, Ireth García-Aguilar, Annette Janning, Christopher P Dlugos, Marco Schäfer-Herte, Christoph Klingner, Mike Wälte, Julian Kuhlmann, Ekaterina Menis, Laura Hockaday Kang, Kerstin C Maier, Wenya Hou, Antonella Russo, Henry N Higgs, Hermann Pavenstädt, Thomas Vogl, Johannes Roth, Britta Qualmann, Michael M Kessels, Dietmar E Martin, Bela Mulder, Roland Wedlich-Söldner
Publikováno v:
eLife, Vol 5 (2016)
Actin has well established functions in cellular morphogenesis. However, it is not well understood how the various actin assemblies in a cell are kept in a dynamic equilibrium, in particular when cells have to respond to acute signals. Here, we chara
Externí odkaz:
https://doaj.org/article/1c44cc24da5646788f05eaf82ed3042d
Autor:
Tak Shun Fung, Rajarshi Chakrabarti, Jana Kollasser, Klemens Rottner, Theresia E.B. Stradal, Frieda Kage, Henry N. Higgs
Publikováno v:
Curr Biol
Mitochondrial damage (MtD) represents a dramatic change in cellular homeostasis, necessitating metabolic changes and stimulating mitophagy. One rapid response to MtD is a rapid peri-mitochondrial actin polymerization termed ADA (acute damage-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa82790223cd398720e8890ec5a06e4
https://europepmc.org/articles/PMC9078333/
https://europepmc.org/articles/PMC9078333/
Autor:
Balajikarthick Subramanian, Henry N. Higgs, Seth L. Alper, Chandra Perez-Gill, Justin Chun, Johannes Schlondorff, Martin R. Pollak, Isaac E. Stillman, Paul Yan
Publikováno v:
J Am Soc Nephrol
Background Mutations in the gene encoding inverted formin-2 (INF2), a member of the formin family of actin regulatory proteins, are among the most common causes of autosomal dominant FSGS. INF2 is regulated by interaction between its N-terminal diaph
Autor:
Rajarshi Chakrabarti, Tak Shun Fung, Taewook Kang, Pieti W. Elonkirjo, Anu Suomalainen, Edward J. Usherwood, Henry N. Higgs
SummaryMitochondrial damage represents a dramatic change in cellular homeostasis, necessitating rapid responses. One rapid response is peri-mitochondrial actin polymerization, termed ADA (acute damage-induced actin). The consequences of ADA are not f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad41bce58e1008608e9b7bc6bb1b7be7
http://hdl.handle.net/10138/356164
http://hdl.handle.net/10138/356164
Publikováno v:
eLife, Vol 4 (2015)
While the dynamin GTPase Drp1 plays a critical role during mitochondrial fission, mechanisms controlling its recruitment to fission sites are unclear. A current assumption is that cytosolic Drp1 is recruited directly to fission sites immediately prio
Externí odkaz:
https://doaj.org/article/386eba9dcc3c4ce5a95a25e7c2a96bd0
Autor:
Thao Huynh, Henry N. Higgs, Zdenek Svindrych, Lisa M. Francomacaro, Mu A, Tommi Kotila, Tak Shun Fung
Publikováno v:
Proc Natl Acad Sci U S A
INF2 is a formin protein that accelerates actin polymerization. A common mechanism for formin regulation is autoinhibition, through interaction between the N-terminal diaphanous inhibitory domain (DID) and C-terminal diaphanous autoregulatory domain
INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury
Autor:
Tatyana Svitkina, Uri Manor, Henry N. Higgs, Jones S, Lingelbach Mj, Barbara Calabrese, Shelley Halpain, Andy Y. Shih, Yamaguchi-Shiraishi Y
During early stages of ischemic brain injury, glutamate receptor hyperactivation mediates neuronal death via osmotic cell swelling. Here we show that ischemia and excess NMDA receptor activation – conditions that trigger neuronal swelling -- cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97ac480ee036f10cd40a0907f75dc5e9
https://doi.org/10.1101/2021.10.01.462790
https://doi.org/10.1101/2021.10.01.462790