Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Henry N Ward"'
Autor:
Emily H. Xiong, Xiang Zhang, Huijuan Yan, Henry N. Ward, Zhen-Yuan Lin, Cassandra J. Wong, Ci Fu, Anne-Claude Gingras, Suzanne M. Noble, Nicole Robbins, Chad L. Myers, Leah E. Cowen
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114601- (2024)
Summary: Fungal pathogens such as Candida albicans pose a significant threat to human health with limited treatment options available. One strategy to expand the therapeutic target space is to identify genes important for pathogen growth in host-rele
Externí odkaz:
https://doaj.org/article/7a90d14f55eb4540a12239260d52e408
Autor:
Kevin Lin, Ya-Chu Chang, Maximilian Billmann, Henry N. Ward, Khoi Le, Arshia Z. Hassan, Urvi Bhojoo, Katherine Chan, Michael Costanzo, Jason Moffat, Charles Boone, Anja-Katrin Bielinsky, Chad L. Myers
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Current approaches to define chemical-genetic interactions (CGIs) in human cell lines are resource-intensive. We designed a scalable chemical-genetic screening platform by generating a DNA damage response (DDR)-focused custom sgRNA library t
Externí odkaz:
https://doaj.org/article/3b9ce5f7b8554685b2e0afb2fc4f3cce
Autor:
Arshia Zernab Hassan, Henry N Ward, Mahfuzur Rahman, Maximilian Billmann, Yoonkyu Lee, Chad L Myers
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 11, Pp n/a-n/a (2023)
Abstract CRISPR‐Cas9 screens facilitate the discovery of gene functional relationships and phenotype‐specific dependencies. The Cancer Dependency Map (DepMap) is the largest compendium of whole‐genome CRISPR screens aimed at identifying cancer
Externí odkaz:
https://doaj.org/article/becc7c92c97a46618bd84cf4cd986a98
MaGIC: a machine learning tool set and web application for monoallelic gene inference from chromatin
Autor:
Svetlana Vinogradova, Sachit D. Saksena, Henry N. Ward, Sébastien Vigneau, Alexander A. Gimelbrant
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-5 (2019)
Abstract Background A large fraction of human and mouse autosomal genes are subject to random monoallelic expression (MAE), an epigenetic mechanism characterized by allele-specific gene expression that varies between clonal cell lineages. MAE is high
Externí odkaz:
https://doaj.org/article/aa9993ef86ab4cee88cfbaf87946b129
Autor:
Mahfuzur Rahman, Maximilian Billmann, Michael Costanzo, Michael Aregger, Amy H Y Tong, Katherine Chan, Henry N Ward, Kevin R Brown, Brenda J Andrews, Charles Boone, Jason Moffat, Chad L Myers
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 5, Pp n/a-n/a (2021)
Abstract We present FLEX (Functional evaluation of experimental perturbations), a pipeline that leverages several functional annotation resources to establish reference standards for benchmarking human genome‐wide CRISPR screen data and methods for
Externí odkaz:
https://doaj.org/article/b77f0c4de34540ad85f7efa1a9046e4b
Autor:
Maximilian Billmann, Henry N. Ward, Michael Aregger, Michael Costanzo, Brenda J. Andrews, Charles Boone, Jason Moffat, Chad L. Myers
Publikováno v:
Cell Systems. 14:418-422.e2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa7e92e0c59da18d58f23021aebb63f2
https://doi.org/10.1016/j.cels.2023.04.003
https://doi.org/10.1016/j.cels.2023.04.003
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 1, p e1004658 (2016)
The explosion of bioinformatics technologies in the form of next generation sequencing (NGS) has facilitated a massive influx of genomics data in the form of short reads. Short read mapping is therefore a fundamental component of next generation sequ
Externí odkaz:
https://doaj.org/article/d276b358482a4dd39a36a68c353e31e0
Autor:
Maximilian Billmann, Henry N. Ward, Michael Aregger, Michael Costanzo, Brenda J. Andrews, Charles Boone, Jason Moffat, Chad L. Myers
CRISPR screens are used extensively to systematically interrogate the phenotype-to-genotype problem. In contrast to early CRISPR screens, which defined core cell fitness genes, most current efforts now aim to identify context-specific phenotypes that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd3e80961ea20458867d45a22780881e
https://doi.org/10.1101/2022.02.19.480892
https://doi.org/10.1101/2022.02.19.480892
Autor:
Charles Boone, Henry N. Ward, Minoru Yoshida, Scott W. Simpkins, Hiroyuki Osada, Justin Nelson, Sheena C. Li, Yoko Yashiroda, Jeff S. Piotrowski, Chad L. Myers, Raamesh Deshpande
Publikováno v:
Nature Protocols. 14:415-440
The construction of genome-wide mutant collections has enabled high-throughput, high-dimensional quantitative characterization of gene and chemical function, particularly via genetic and chemical–genetic interaction experiments. As the throughput o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90822d6a0564d445e2aa6a0ba0f68c65
https://doi.org/10.1038/s41596-018-0099-1
https://doi.org/10.1038/s41596-018-0099-1
Autor:
Chad L. Myers, Henry N. Ward, Maximilian Billmann, Ya-Chu Chang, Anja Katrin Bielinsky, Kevin Lin
Publikováno v:
Journal of Clinical and Translational Science. 5:101-102
IMPACT: The key to advancing precision medicine is to deepen our understanding of drug modes-of-action (MOA). This project aims to develop a novel method for predicting MOA of potential drug compounds, providing an experimental and computational plat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1bb8b909b05c042414cd1c7593e47bf
https://doi.org/10.1017/cts.2021.661
https://doi.org/10.1017/cts.2021.661