Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Henry Morrison"'
Autor:
Henry Morrison, Christopher S. Regens, Joshua R. Dunetz, Olga Lapina, Nisha P. Shah, Brenda J. Burke, Todd Wenderski, Sylvie M. Asselin, Tiago Vieira
Publikováno v:
Organic Process Research & Development. 26:1258-1267
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3da7532ffdea614720ca38ad8155d0b8
https://doi.org/10.1021/acs.oprd.2c00003
https://doi.org/10.1021/acs.oprd.2c00003
Autor:
Sean Ritchie, Michael J. Geier, Philippa Payne, Remus Osan, Elizabeth M. Horstman, Henry Morrison, Ernest Lee, Mark E. Scott, Xiaotian Wang
Publikováno v:
Organic Process Research & Development. 25:1036-1046
Presented herein is an approach for correlating active pharmaceutical ingredient (API) bulk properties such as particle size, surface area, powder flow, morphology, and dissolution in order to prov...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::370bba6d1d111433ac2db3219c9cf5eb
https://doi.org/10.1021/acs.oprd.1c00043
https://doi.org/10.1021/acs.oprd.1c00043
Autor:
Alan M. Allgeier, Krishnakumar Ranganathan, Seb Caille, Sheng Cui, Andrew Cosbie, Jacqueline C. S. Woo, Steven M. Mennen, Oliver R. Thiel, Shawn D. Walker, Justin T. Tvetan, Seth Huggins, Neil F. Langille, Richard D. Crockett, Xianqing Shi, Karl B. Hansen, Charles Bernard, Kyle Quasdorf, Fang Wang, Alexander Muci, Bradley P Morgan, Philipp Roosen, Steven Wu, Henry Morrison, Tiffany L. Correll, Margaret M. Faul, Karthik Nagapudi
Publikováno v:
Organic Process Research & Development. 23:1558-1567
The development of a factory process to manufacture the novel cardiac myosin activator omecamtiv mecarbil (1) is described. Omecamtiv mecarbil is prepared via the convergent synthesis and coupling ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6f4fdc9437c03c0ff4b2e4caac4c921
https://doi.org/10.1021/acs.oprd.9b00200
https://doi.org/10.1021/acs.oprd.9b00200
Publikováno v:
Organic Process Research & Development. 22:1432-1440
GS-X and GS-Y are novel active pharmaceutical ingredients (APIs) selected for early clinical development. For each API, two slightly hygroscopic unsolvated polymorphs were identified, and investigations of these phases were required to identify the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39f2d8a3fafae1a5388038c93f61a95a
https://doi.org/10.1021/acs.oprd.8b00253
https://doi.org/10.1021/acs.oprd.8b00253
Publikováno v:
Organic Process Research & Development. 19:1842-1848
The appearance of a new solid phase during the development of a small molecule presents significant challenges for optimizing form control during crystallization and mitigating potential delays in development timelines. Herein we present a case study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::241a67a507ff5c3de64c35cfad6cc72f
https://doi.org/10.1021/acs.oprd.5b00030
https://doi.org/10.1021/acs.oprd.5b00030
Autor:
Karthik Nagapudi, Seth Huggins, William Trieu, Sheng Cui, Henry Morrison, Shawn D. Walker, Wenle Tao
Publikováno v:
Organic Process Research & Development. 19:1076-1081
The purpose of this study was to correlate the particle size distribution (PSD) of a development molecule (1) with other bulk properties such as surface area and powder flow, to enable prediction of critical quality attributes (CQA) of the drug subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3be795244b0459bed9d4ec43759604f0
https://doi.org/10.1021/op400333u
https://doi.org/10.1021/op400333u
Autor:
Van Luu, Henry Morrison, Helming Tan, Mary K. Stanton, Karthik Nagapudi, Janan Jona, Matthew Peterson
Publikováno v:
International Journal of Pharmaceutics. 441:356-364
A 96-well high-throughput cocrystal screening workflow has been developed consisting of solvent-mediated sonic blending synthesis and on-plate solid/solution stability characterization by XRPD. A strategy of cocrystallization screening in selected bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f03d09d3b35c72ee0153053aa6e82a0
https://doi.org/10.1016/j.ijpharm.2012.11.020
https://doi.org/10.1016/j.ijpharm.2012.11.020
Autor:
Josh D Toschi, Melissa Mrozek-Morrison, Helming Tan, Henry Morrison, Van Luu, Dominick Daurio
Publikováno v:
Organic Process Research & Development. 17:533-539
The application of sonication of moist powders in a sonic bath through the use of a floating foam rack was investigated as an inexpensive bench-top high throughput platform for first pass co-crystal screening. The feasibility of this method was teste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ff7b6a4506f4af75244a8acc922827b
https://doi.org/10.1021/op3002382
https://doi.org/10.1021/op3002382
Autor:
Andrew Tasker, Andrea Itano, Anu Gore, Paul E. Harrington, Mike Frohn, Victor J. Cee, Michele McElvain, Min Wong, Mike Fiorino, Alexander J. Pickrell, Kelvin K. C. Sham, Han Xu, Brian A. Lanman, Anthony B. Reed, Yang Xu, Susana C. Neira, Scot Middleton, Henry Morrison
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1779-1783
Replacement of the azetidine carboxylate of an S1P1 agonist development candidate, AMG 369, with a range of acyclic head-groups led to the identification of a novel, S1P3-sparing S1P1 agonist, (−)-2-amino-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f3cc5bea5e6a249ac305b5230ca5f2
https://doi.org/10.1016/j.bmcl.2011.12.073
https://doi.org/10.1016/j.bmcl.2011.12.073
Autor:
Kelvin K. C. Sham, Lewis D. Pennington, Paul E. Harrington, Matthew R. Lee, Michele McElvain, Xuxia Zhang, Heather A. Arnett, Min Wong, Alexander J. Pickrell, Anthony B. Reed, Henry Morrison, Victor J. Cee, Mike Fiorino, Christopher H. Fotsch, Michael J. Frohn, Yang Xu, Michael Croghan, Han Xu, Brian A. Lanman, Andrew Tasker, Michelle Horner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:527-531
We reveal how a N-scan SAR strategy (systematic substitution of each CH group with a N atom) was employed for quinolinone-based S1P(1) agonist 5 to modulate physicochemical properties and optimize in vitro and in vivo activity. The diaza-analog 17 di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e9317f7724366d80a0b866a4ab4feca
https://doi.org/10.1016/j.bmcl.2011.10.085
https://doi.org/10.1016/j.bmcl.2011.10.085