Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Henry M, Miziorko"'
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 308:R872-R878
The objective of this study was to determine the potential role of astrocyte-derived ketone bodies in regulating the early changes in caloric intake of diet induced-obese (DIO) versus diet-resistant (DR) rats fed a 31.5% fat high-energy (HE) diet. Af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8d487f7cfe80dcc89d4cfc8483af10
https://doi.org/10.1152/ajpregu.00015.2015
https://doi.org/10.1152/ajpregu.00015.2015
Autor:
D. Andrew Skaff, William J. McWhorter, Henry M. Miziorko, Gerald J. Wyckoff, Brian V. Geisbrecht
Publikováno v:
Archives of Biochemistry and Biophysics. 566:1-6
Mevalonate diphosphate decarboxylase (MDD; EC 4.1.1.33) catalyzes the irreversible decarboxylation of mevalonate diphosphate in the mevalonate pathway to form isopentenyl diphosphate, which is a precursor in the biosynthesis of many essential polyiso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dea7e91c80b17bf71691e157a64860a
https://doi.org/10.1016/j.abb.2014.12.002
https://doi.org/10.1016/j.abb.2014.12.002
Autor:
D. A. Skaff, James K. Addo, Andrew Keightley, Henry M. Miziorko, Gerald J. Wyckoff, John VanNice
Publikováno v:
Journal of Bacteriology. 196:1055-1063
Mevalonate (MVA) metabolism provides the isoprenoids used in archaeal lipid biosynthesis. In synthesis of isopentenyl diphosphate, the classical MVA pathway involves decarboxylation of mevalonate diphosphate, while an alternate pathway has been propo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd231cd7b405167cf21561d50b243a06
https://doi.org/10.1128/jb.01230-13
https://doi.org/10.1128/jb.01230-13
Publikováno v:
Journal of Bacteriology. 195:3854-3862
Enzymes of the isoprenoid biosynthetic pathway in halophilic archaea remain poorly characterized, and parts of the pathway remain cryptic. This situation may be explained, in part, by the difficulty of expressing active, functional recombinant forms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc36c4eef040f7b9b488f69237b94ee
https://doi.org/10.1128/jb.00485-13
https://doi.org/10.1128/jb.00485-13
Autor:
Jeffrey C. Murphy, Brian J. Moldover, Ada Solidar, Henry M. Miziorko, Gerald J. Wyckoff, Christa Montgomery
Publikováno v:
The Open Medicinal Chemistry Journal
ChemVassa, a new chemical structure search technology, was developed to allow rapid in silico screening of compounds for hit and hit-to-lead identification in drug development. It functions by using a novel type of molecular descriptor that examines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be650e5cdc7d02820dca948b7303a452
https://doi.org/10.2174/1874104501206010029
https://doi.org/10.2174/1874104501206010029
Publikováno v:
Biochemistry. 51:5611-5621
Mevalonate diphosphate decarboxylase (MDD) catalyzes the final step of the mevalonate pathway, the Mg{sup 2+}-ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP), producing isopentenyl diphosphate (IPP). Synthesis of IPP, an isoprenoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1956551550f0f25e25515084693b8088
https://doi.org/10.1021/bi300591x
https://doi.org/10.1021/bi300591x
Autor:
D. Andrew Skaff, Michael L. Barta, William J. McWhorter, Henry M. Miziorko, Kasra X. Ramyar, Brian V. Geisbrecht
Publikováno v:
Biochemistry. 51:4713-4722
Hymeglusin (1233A, F244, L-659-699) is established as a specific β-lactone inhibitor of eukaryotic hydroxymethylglutaryl-CoA synthase (HMGCS). Inhibition results from formation of a thioester adduc...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::676968c7be2da2558a8bcb2aa415197e
https://doi.org/10.1021/bi300037k
https://doi.org/10.1021/bi300037k
Autor:
Christa Montgomery, Henry M. Miziorko
Publikováno v:
Archives of Biochemistry and Biophysics. 511:48-55
Human 3-hydroxy-3-methylglutaryl-CoA lyase catalyzes formation of acetyl-CoA and acetoacetate in a reaction that requires divalent cation and is stimulated by sulfhydryl protective reagents. The enzyme is a homodimer and inter-subunit adducts form in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e93d13a5d3d217b56fec26414b38b23
https://doi.org/10.1016/j.abb.2011.04.004
https://doi.org/10.1016/j.abb.2011.04.004
Autor:
Henry M. Miziorko
Publikováno v:
Archives of Biochemistry and Biophysics. 505:131-143
The mevalonate pathway accounts for conversion of acetyl-CoA to isopentenyl 5-diphosphate, the versatile precursor of polyisoprenoid metabolites and natural products. The pathway functions in most eukaryotes, archaea, and some eubacteria. Only recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f17f93940a5a4516a15601f6c6823f
https://doi.org/10.1016/j.abb.2010.09.028
https://doi.org/10.1016/j.abb.2010.09.028
Autor:
Timothy J. Herdendorf, Daniel S. Sem, Patchareenart Saparpakorn, Sheng Cai, Henry M. Miziorko, Huili Yao, Andrew L. Olson, Supa Hannongbua
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 75:127-138
Phosphomevalonate kinase (PMK) catalyzes an essential step in the mevalonate pathway, which is the only pathway for synthesis of isoprenoids and steroids in humans. PMK catalyzes transfer of the gamma-phosphate of ATP to mevalonate 5-phosphate (M5P)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::512abb6a3629be7032e2a361079d5dd5
https://doi.org/10.1002/prot.22228
https://doi.org/10.1002/prot.22228