Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Henry Lee-Six"'
Autor:
Taryn D. Treger, John E. G. Lawrence, Nathaniel D. Anderson, Tim H. H. Coorens, Aleksandra Letunovska, Emilie Abby, Henry Lee-Six, Thomas R. W. Oliver, Reem Al-Saadi, Kjell Tullus, Guillaume Morcrette, J. Ciaran Hutchinson, Dyanne Rampling, Neil Sebire, Kathy Pritchard-Jones, Matthew D. Young, Thomas J. Mitchell, Philip H. Jones, Maxine Tran, Sam Behjati, Tanzina Chowdhury
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Reninomas are exceedingly rare renin-secreting kidney tumours that derive from juxtaglomerular cells, specialised smooth muscle cells that reside at the vascular inlet of glomeruli. They are the central component of the juxtaglomerular appar
Externí odkaz:
https://doaj.org/article/bf323a439c8641f5a4c650d7e939dabe
Autor:
Philip S. Robinson, Laura E. Thomas, Federico Abascal, Hyunchul Jung, Luke M. R. Harvey, Hannah D. West, Sigurgeir Olafsson, Bernard C. H. Lee, Tim H. H. Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A. Sanders, Stefanie V. Lensing, Simon J. A. Buczacki, Rogier ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J. Campbell, Iñigo Martincorena, Julian R. Sampson, Michael R. Stratton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Inherited mutations in MUTYH have been shown to predispose patients to colorectal cancers. Here, the authors show that MUTYH mutations lead to an increased somatic base substitution mutation rate in normal intestinal epithelial cells, which is the li
Externí odkaz:
https://doaj.org/article/c14b563faf084d9f9abf9b953d1b62bf
Autor:
Bernard C. H. Lee, Philip S. Robinson, Tim H. H. Coorens, Helen H. N. Yan, Sigurgeir Olafsson, Henry Lee-Six, Mathijs A. Sanders, Hoi Cheong Siu, James Hewinson, Sarah S. K. Yue, Wai Yin Tsui, Annie S. Y. Chan, Anthony K. W. Chan, Siu Lun Ho, Peter J. Campbell, Inigo Martincorena, Simon J. A. Buczacki, Siu Tsan Yuen, Suet Yi Leung, Michael R. Stratton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
It is unclear whether somatic mutation rates are elevated in Lynch Syndrome (LS), which is the most common cause of hereditary colorectal cancer. Here, the authors use whole-genome sequencing and organoid cultures to show that normal tissues in LS pa
Externí odkaz:
https://doaj.org/article/9ffe8e161f6f47b6ae292571819e0a78
Autor:
Marios Giannakis, Shuji Ogino, Kana Wu, Charles S. Fuchs, Edward L. Giovannucci, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Eliezer M. Van Allen, Mingyang Song, Andrew D. Cherniack, Xuehong Zhang, Tomotaka Ugai, Brendan Reardon, Henry Lee-Six, Liam F. Spurr, Yvonne Y. Li, Koichiro Haruki, Rong Zhong, Carino Gurjao
Supplemental Figure 1: Non-negative matrix factorization rank survey in NHS/HPFS Quality measures for Non-negative matrix factorization in NHS/ HPFS, as described in the R package "NMF". Arrows indicate the estimated rank of mutational signatures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0d7e67eed87b3bbe441d5c1d6e7f55
https://doi.org/10.1158/2159-8290.22539932.v1
https://doi.org/10.1158/2159-8290.22539932.v1
Autor:
Sam M. Janes, Nicholas McGranahan, Sergio A. Quezada, Yinyin Yuan, Teresa Marafioti, Peter J. Campbell, Christina Thirlwell, Charles Swanton, Jeremy George, Ricky M. Thakrar, Lisa M. Coussens, Courtney Betts, William Larson, Marie-Liesse Asselin-Labat, Claire Marceaux, Bernadette Carroll, Andrew J. Furness, Pascal F. Durrenberger, Sophia Antoniou, David A. Moore, Mary Falzon, Celine Denais, Yeman B. Hagos, Fraser R. Millar, Jake Y. Henry, Kate H.C. Gowers, Robert E. Hynds, Henry Lee-Six, Christodoulos P. Pipinikas, Deepak P. Chandrasekharan, Lukas Kalinke, Rachel Rosenthal, Ayse U. Akarca, Tom Lund, Shan E. Ahmed Raza, Khalid AbdulJabbar, Vitor H. Teixeira, Adam Pennycuick
Immune cell deconvolution from molecular data. Relative proportions of immune cell subtypes are predicted from gene expression data using the Danaher method, and from methylation data using methylCIBERSORT. Differences between progressive and regress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0408e249465611db42368906c8f88642
https://doi.org/10.1158/2159-8290.22536935.v1
https://doi.org/10.1158/2159-8290.22536935.v1
Autor:
Marios Giannakis, Shuji Ogino, Kana Wu, Charles S. Fuchs, Edward L. Giovannucci, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Eliezer M. Van Allen, Mingyang Song, Andrew D. Cherniack, Xuehong Zhang, Tomotaka Ugai, Brendan Reardon, Henry Lee-Six, Liam F. Spurr, Yvonne Y. Li, Koichiro Haruki, Rong Zhong, Carino Gurjao
Several risk factors have been established for colorectal cancer, yet their direct mutagenic effects in patients' tumors remain to be elucidated. Here, we leveraged whole-exome sequencing data from 900 colorectal cancer cases that had occurred in thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b0381831cb5659bf5782139937c8df
https://doi.org/10.1158/2159-8290.c.6549212
https://doi.org/10.1158/2159-8290.c.6549212
Autor:
Sam M. Janes, Nicholas McGranahan, Sergio A. Quezada, Yinyin Yuan, Teresa Marafioti, Peter J. Campbell, Christina Thirlwell, Charles Swanton, Jeremy George, Ricky M. Thakrar, Lisa M. Coussens, Courtney Betts, William Larson, Marie-Liesse Asselin-Labat, Claire Marceaux, Bernadette Carroll, Andrew J. Furness, Pascal F. Durrenberger, Sophia Antoniou, David A. Moore, Mary Falzon, Celine Denais, Yeman B. Hagos, Fraser R. Millar, Jake Y. Henry, Kate H.C. Gowers, Robert E. Hynds, Henry Lee-Six, Christodoulos P. Pipinikas, Deepak P. Chandrasekharan, Lukas Kalinke, Rachel Rosenthal, Ayse U. Akarca, Tom Lund, Shan E. Ahmed Raza, Khalid AbdulJabbar, Vitor H. Teixeira, Adam Pennycuick
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c889c181198e05bf5aa948da6e69f5d
https://doi.org/10.1158/2159-8290.22536944.v1
https://doi.org/10.1158/2159-8290.22536944.v1
Autor:
Marios Giannakis, Shuji Ogino, Kana Wu, Charles S. Fuchs, Edward L. Giovannucci, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Eliezer M. Van Allen, Mingyang Song, Andrew D. Cherniack, Xuehong Zhang, Tomotaka Ugai, Brendan Reardon, Henry Lee-Six, Liam F. Spurr, Yvonne Y. Li, Koichiro Haruki, Rong Zhong, Carino Gurjao
Tables S1 S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1594fc923bdb214ca665d6f823cabb68
https://doi.org/10.1158/2159-8290.22539881
https://doi.org/10.1158/2159-8290.22539881
Autor:
Sam M. Janes, Nicholas McGranahan, Sergio A. Quezada, Yinyin Yuan, Teresa Marafioti, Peter J. Campbell, Christina Thirlwell, Charles Swanton, Jeremy George, Ricky M. Thakrar, Lisa M. Coussens, Courtney Betts, William Larson, Marie-Liesse Asselin-Labat, Claire Marceaux, Bernadette Carroll, Andrew J. Furness, Pascal F. Durrenberger, Sophia Antoniou, David A. Moore, Mary Falzon, Celine Denais, Yeman B. Hagos, Fraser R. Millar, Jake Y. Henry, Kate H.C. Gowers, Robert E. Hynds, Henry Lee-Six, Christodoulos P. Pipinikas, Deepak P. Chandrasekharan, Lukas Kalinke, Rachel Rosenthal, Ayse U. Akarca, Tom Lund, Shan E. Ahmed Raza, Khalid AbdulJabbar, Vitor H. Teixeira, Adam Pennycuick
Before squamous cell lung cancer develops, precancerous lesions can be found in the airways. From longitudinal monitoring, we know that only half of such lesions become cancer, whereas a third spontaneously regress. Although recent studies have descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a98571a5212598e8738475feb59ae69d
https://doi.org/10.1158/2159-8290.c.6548276.v1
https://doi.org/10.1158/2159-8290.c.6548276.v1
Autor:
Peter Ellis, Luiza Moore, Mathijs A. Sanders, Timothy M. Butler, Simon F. Brunner, Henry Lee-Six, Robert Osborne, Ben Farr, Tim H. H. Coorens, Andrew R. J. Lawson, Alex Cagan, Mike R. Stratton, Inigo Martincorena, Peter J. Campbell
Publikováno v:
Nature Protocols.