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pro vyhledávání: '"Henry Lardy"'
Group Transfer Syntheses Coupled to ATP Cleavage
Publikováno v:
Proceedings of the National Academy of Sciences. 95:11083-11088
It is known that androst-5-ene-3β,17β-diol (Adiol), a precursor of testosterone (T), can activate estrogen target genes. The androgenic activity of Adiol itself, however, is poorly understood. Using a transient transfection assay, we here demonstra
Publikováno v:
Vitamins and hormones. 71
Dehydroepiandrosterone (DHEA), produced from cholesterol in the adrenals, is the most abundant steroid in our circulation. It is present almost entirely as the sulfate ester, but the free steroid is the form that serves as a precursor of estrogens an
Publikováno v:
Journal of chromatography. A. 964(1-2)
The signal response of moderately polar to nonpolar neutral steroidal compounds in positive ion mode was significantly improved in electrospray ionization mode by addition of volatile organic acids (trifluoroacetic acid, acetic and formic) at concent
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 767(2)
Because relatively large amounts of dehydroepiandrosterone (DHEA) are required to demonstrate its diverse metabolic effects, it is postulated that this steroid may be converted to more active molecules. To search for the possible receptor-recognized
Publikováno v:
Steroids. 67(3-4)
Our previous finding that D-ring seco derivatives of dehydroepiandrosterone retained biologic activity (Reich et al., Steroids 1998;63:542-53) motivated us to synthesize and test a number of steroids in which the D-ring is retained but altered in var
Autor:
Henry Lardy
Publikováno v:
Science. 272:335-335
Autor:
Henry Lardy
Publikováno v:
Trends in Biochemical Sciences. 3:93-94
Publikováno v:
Biochemistry. 5:3383-3383