Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Henry K.W. Fong"'
Autor:
Zhaoxia Zhang, Shikun He, Henry K.W. Fong, Xiaohua Li, Xuan Bao, Harold Kochounian, Lvzhen Huang, Christopher Buser, Fred N. Ross-Cisneros, Mingwei Zhao, Yanjiang Guo, Alfredo A. Sadun, Nancy Wu, Bin Sun
Publikováno v:
The American journal of pathology, vol 191, iss 8
Am J Pathol
Am J Pathol
Age-related macular degeneration (AMD) is a progressive eye disease and the most common cause of blindness among the elderly. AMD is characterized by early atrophy of the choriocapillaris and retinal pigment epithelium (RPE). Although AMD is a multif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192db9a9beff3fe9dd74980d4dc79676
https://escholarship.org/uc/item/7c53t2v5
https://escholarship.org/uc/item/7c53t2v5
Publikováno v:
Journal of Biological Chemistry. 276:21098-21104
Vertebrate opsins in both photoreceptors and the retinal pigment epithelium (RPE) have fundamental roles in the visual process. The visual pigments in photoreceptors are bound to 11-cis-retinal and are responsible for the initiation of visual excitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42870049ebc9820594ffc0ca3d736276
https://doi.org/10.1074/jbc.m010441200
https://doi.org/10.1074/jbc.m010441200
Autor:
Wenshan Hao, Henry K.W. Fong
Publikováno v:
Journal of Biological Chemistry. 274:6085-6090
The recent identification of nonvisual opsins has revealed an expanding family of vertebrate opsin genes. The retinal pigment epithelium (RPE) and Müller cells contain a blue and UV light-absorbing opsin, the RPE retinal G protein-coupled receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114dcb1cc1ff8eb978aeadbe61a701df
https://doi.org/10.1074/jbc.274.10.6085
https://doi.org/10.1074/jbc.274.10.6085
Autor:
Harvey K. Yamane, Henry K.W. Fong, Rehwa H. Lee, Bernard K.-K. Fung, Dean Bok, Olivia C. Ong, Kim B. Phan
Publikováno v:
Journal of Biological Chemistry. 270:8495-8500
The phototransduction process in cones has been proposed to involve a G protein that couples the signal from light-activated visual pigment to the effector cyclic GMP phosphodiesterase. Previously, we have identified and purified a G beta gamma compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77aa014d281272c62b604e87f46142cc
https://doi.org/10.1074/jbc.270.15.8495
https://doi.org/10.1074/jbc.270.15.8495
Publikováno v:
Experimental Eye Research. 56:497-507
Transducin, the major photoreceptor guanine nucleotide-binding protein (G protein), is composed of three polypeptides: alpha, beta and gamma subunits. The transducin gamma subunit (T gamma) is expressed preferentially in photoreceptors. To study the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9ac675cee0d018808cfb3fdbcc0d59
https://doi.org/10.1006/exer.1993.1063
https://doi.org/10.1006/exer.1993.1063
Human retinal pigment epithelial (RPE) cells synthesize an extraneous splice isoform of retinal G protein-coupled receptor (RGR). In this study, we analyzed the exon-skipping variant of RGR (RGR-d) that is found in extracellular deposits. RPE-choroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce0a10e603d8c233b7bc578ef9009e0
https://europepmc.org/articles/PMC2763577/
https://europepmc.org/articles/PMC2763577/
Publikováno v:
Experimental eye research. 83(1)
An extraneous exon-skipping mRNA encodes an altered form of a light-absorbing opsin in human retina and pigment epithelium (RPE). The predicted protein variant differs from full-length RPE-retinal G protein-coupled receptor (RGR) by having an in-fram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dca7961698d43eb4512579271c8e439
https://pubmed.ncbi.nlm.nih.gov/16530760
https://pubmed.ncbi.nlm.nih.gov/16530760
Publikováno v:
Human Genetics. 97:720-722
The human RGR gene encodes an opsin protein (retinal G protein-coupled receptor), which is expressed in Müller cells and the retinal pigment epithelium and is thought to play a role in the visual process. To investigate a possible linkage of the RGR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a7bcf707a745c90101fd2af0e9a03b
https://doi.org/10.1007/bf02346179
https://doi.org/10.1007/bf02346179
Autor:
J. Preston Van Hooser, Tadao Maeda, Vladimir A. Kuksa, Krzysztof Palczewski, Henry K.W. Fong, Geeng-Fu Jang, Peter B. Detwiler, Fred Rieke, Yu-Guang He, Yan Liang
Publikováno v:
The Journal of biological chemistry. 277(21)
The visual process is initiated by the photoisomerization of 11-cis-retinal to all-trans- retinal. For sustained vision the 11-cis-chromophore must be regenerated from all-trans-retinal. This requires RPE65, a dominant retinal pigment epithelium prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf87044a1ef65470e6833be43a44d903
https://pubmed.ncbi.nlm.nih.gov/11897783
https://pubmed.ncbi.nlm.nih.gov/11897783
Autor:
Henry K.W. Fong, Mao Yang
Publikováno v:
The Journal of biological chemistry. 277(5)
Light-dependent production of 11-cis-retinal by the retinal pigment epithelium (RPE) and normal regeneration of rhodopsin under photic conditions involve the RPE retinal G protein-coupled receptor (RGR) opsin. This microsomal opsin is bound to all-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808df9ad19e95375495aa499b29298d4
https://pubmed.ncbi.nlm.nih.gov/11723126
https://pubmed.ncbi.nlm.nih.gov/11723126