Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Henry J. Showell"'
Autor:
Janet A. Houser, Henry J. Showell, Caroline C. Whitacre, Glen Apseloff, Maryrose J. Conklyn, Arlene C Johnson, Keith D. Wilner, Theodore E. Liston
Publikováno v:
British Journal of Clinical Pharmacology. 45:115-121
Aims CP-105,696, (+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxy-chroman-7-yl] cyclopropane carboxylic acid is a potent, novel LTB4 receptor antagonist advanced to clinical trials to determine its efficacy in inflammatory diseases. The pharmacokinetics a
Autor:
Geraldine L. Crean, R. Breslow, John J. Martin, Maryrose J. Conklyn, Cathy A. Farrell, G. Todd Miller, M. S. Biggers, Hada William Andrew, Henry J. Showell, Kevin Koch, Ellen R. Laird, John B. Cheng, Lawrence A. Reiter, Lawrence S. Melvin, Joanne S. Pillar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2307-2312
The SAR of a series of 7-chromanylacetic acids has been investigated with the aim of identifying potent and selective LTB4 receptor antagonists. We found optimal activity in derivatives with c~,c~-disubstitution on the acetic acid and a C-4 hydroxy g
Publikováno v:
Cytokine. 8:762-766
The effect of anticoagulant (heparin vs EDTA) on chemokine induced CD11b upregulation on neutrophils, eosinophils, and monocytes in human whole blood was determined. For most of the chemokines (IL-8, GRO-alpha, MCP-1, MIP-1 alpha) the difference in t
Publikováno v:
British Journal of Pharmacology. 117:1127-1132
1. Binding of [3H]-leukotriene B4 ([3H]-LTB4) to murine spleen membranes (MSM) was determined. 2. Scatchard analyses of [3H]-LTB4 binding indicated the presence of high (KD1 = 1.7 nM) and low (KD2 = 7.5 nM) affinity receptors on MSM with Bmax values
Autor:
Ronald P. Gladue, Henry J. Showell, D. N. Scampoli, E. D. Salter, E. R. Pettipher, L A Carroll, L Contillo, A J Milici, Hans Stukenbrok
Publikováno v:
The Journal of Experimental Medicine
Leukotriene B4 (LTB4) is a chemotactic and cell-activating factor present at inflammatory sites in a variety of autoimmune diseases including multiple sclerosis (MS). In this study, we used a murine model of MS, experimental allergic encephalomyeliti
Autor:
Hiroko Masamune, J.T. Shirley, A. Marfat, John B. Cheng, Henry J. Showell, James F. Eggler, J.S. Pillar, Maryrose J. Conklyn, Jeanene E. Tickner, Lawrence S. Melvin, R. Breslow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:887-892
The development of novel LTB 4 antagonists from a class of quinolylmethyl LTD 4 antagonists is described. These α-methyl quinolylmethyl chromanols were found to have good vitro activity.
Autor:
Maryrose J. Conklyn, Henry J. Showell, Patricia A. Connelly, Joseph M. Merenda, Cathy A. Farrell
Publikováno v:
Biochemical and Biophysical Research Communications. 177:192-201
Phosphotyrosine-containing proteins were detected by western blotting of whole cell lysates of purified human neutrophils or rat basophilic leukemia cells (RBL-2H3) using a polyclonal anti-phosphotyrosine antibody. When either cell type was stimulate
Autor:
Keita Kasahara, Ronald M. Allen, Theodore J. Standiford, Robert M. Strieter, Steven L. Kunkel, Henry J. Showell
Publikováno v:
Biochemical and Biophysical Research Communications. 173:725-730
The evolution of acute inflammation from initiation through resolution is associated with the changing character of the infiltrating leukocytes. Recruitment of these leukocytes is dependent upon the generation of chemotactic factors that have either
Publikováno v:
American Review of Respiratory Disease. 142:1093-1098
We determined the pulmonary obstructive response to aerosolized antigen challenge, and its sensitivity to antagonists of specific lipid mediators, in IgG, passively sensitized (IgG1-PS) guinea pigs. Antiovalbumin (OA)-IgG1 was isolated by affinity ch
Autor:
P.P.B. Yeo, C.G.A. Persson, Egil Olsen, P. M. de Beer, A.K.M. Ekramoddoullah, N.R. Kitteringham, Tom Hatton, Robert Y. Lin, David J. Walsh, I. Erjefält, J. Morley, Harold Ralph, Federico Guillermo Lorenzana, A. Kristersson, E.S.K. Assem, I. Chapman, Anne-Marie A. Irani, Christian Müller, S. Sanjar, Steven J. Burakoff, Dean D. Metcalfe, A.D. Wilson, J.B. Clarke, U. Oreste, Lo Schiavo, F.T. Kisil, K.F. Lui, V. Santonastaso, C.R. Stokes, Xaver Baur, A.C. Thai, Shyam S. Mohapatra, Zvezdana Vuk-Pavlovic, J.R. Joubert, Robert B. Bressler, Alec H. Sehon, J.S. Cheah, P.W. Bland, Kathleen E. Harris, Henry J. Showell, Maryrose J. Conklyn, J.L. Maggs, Robert Hill, Saul B. Kadin, B.K. Park, Gertraud Mazur, J.A. Kiernan, A. Ruffilli, P.J. Bouic, Andre Silvanovitch, Arnolds.K. Kirshenbaum, Steven J. Mentzer, Paula Maxwell, J A Barbosa, Hermann M. Wolf, W.Y. Ng, M.A. Kings, Lawrence B. Schwartz, Jay Valinsky, Jayne A. Matthews, Matthew Davidson, Marc M. Friedman, A. Luts, G. Sacerdoti, Edward Nygren, Scotto d’Abusco, Barbara Jarosch, Russell Denmeade, Josef Göttlicher, Jim Astwood, M.R. Coscia, Roy Patterson, F. Sundler, Matthew R. Walker, Martha M. Eibl, Michael S. Rohrbach
Publikováno v:
International Archives of Allergy and Immunology. 91:I-VI