Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Henry J. Pieniaszek"'
Autor:
William F. Ebling, Dietmar A. Seiffert, Henry J. Pieniaszek, Yu Chen Barrett, Jeffrey T. Billheimer
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 44:938-946
Thrombocytopenia exposes patients to increased bleeding risk. This serious adverse event was observed with a frequency of approximately 2% in early clinical trials with the potent, orally bioavailable glycoprotein (GP) IIb/IIIa receptor antagonist ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328c6153b56491b61d63cf84d37888d6
https://doi.org/10.1016/j.jpba.2007.03.030
https://doi.org/10.1016/j.jpba.2007.03.030
Autor:
Anthony Sferruzza, Henry J. Pieniaszek, Dietmar A. Seiffert, Gregory F Hollis, Robert N. Daly, Donna L. Pedicord, Robert B. Stein, Tsushung A. Hua, Andrew M. Stern, Debra Cromley, Cathy J. Kieras, William Ebling, Bokang He, Richard Wynn, Richard J. Rossi, Yu Chen Barrett, Jeffrey T. Billheimer
Publikováno v:
Blood. 101:58-63
Thrombocytopenia is a relatively common side effect observed during glycoprotein (GP) IIb/IIIa antagonist therapy. With the oral antagonist roxifiban, we observed thrombocytopenia, defined as 50% reduction of platelets over predose values or below 90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceca59e70f8405bc557ad2ffe1b60ed6
https://doi.org/10.1182/blood-2002-02-0471
https://doi.org/10.1182/blood-2002-02-0471
Autor:
Henry J. Pieniaszek, Racehl A Wilcox, R. Scott Wright, Joseph G. Murphy, William Ebling, Ihor Gussak, Stephen L. Kopecky, Sherwin K. B. Sy, Kristen Simonson, Robert N Daly, Brent A. Williams, Valerie A. Cain
Publikováno v:
American Journal of Cardiovascular Drugs. 3:101-112
Introduction: Intravenous platelet glycoprotein (GP) IIb/IIIa receptor inhibitors have a significant beneficial impact on the outcomes of patients undergoing high-risk coronary interventions and in the stabilization of patients with unstable angina p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4396bf92047bf0a85221994b8bf558a6
https://doi.org/10.2165/00129784-200303020-00004
https://doi.org/10.2165/00129784-200303020-00004
Autor:
William Ebling, David M. Kornhauser, Su Ma, Sherwin K. B. Sy, John T. Mondick, Henry J. Pieniaszek, Michael J. Fossler, Valerie A. Cain
Publikováno v:
The Journal of Clinical Pharmacology. 42:738-753
Roxifiban is an esterprodrug that is hydrolyzed, after oral administration, to the active glycoprotein (GP) IIb/IIIa antagonist, XV459. The objectives of the study were to investigate the safety, tolerability, pharmacokinetics, and the time course of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3fc5f268e8c6bf3d0a888e8905d44f
https://doi.org/10.1177/009127002401102687
https://doi.org/10.1177/009127002401102687
Autor:
David M. Kornhauser, James W. Hainer, Jeffrey S. Barrett, William Knebel, Kristen Johansen, Tsushung A. Hua, Henry J. Pieniaszek, J.J. van Lier, James L. Gaskill, Per Sprogel
Publikováno v:
Thrombosis Research. 101:243-254
Tinzaparin, a sodium salt of a low-molecular-weight heparin (LMWH) produced via heparinase digestion, is used for the treatment of deep vein thrombosis (DVT) and pulmonary embolism in conjunction with warfarin for the prevention of DVT in patients un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91d1f8e9eee739f62d128af30289c3d
https://doi.org/10.1016/s0049-3848(00)00412-6
https://doi.org/10.1016/s0049-3848(00)00412-6
Autor:
Foster Brown, William F. Ebling, Shaker A. Mousa, Ram Kapil, Thomas M. Reilly, Patricia K. Padovani, Henry J. Pieniaszek, Jun Yu, Jeffrey S. Barrett, Jeffrey M. Bozarth, Martha H. Corjay
Publikováno v:
Biopharmaceutics & Drug Disposition. 20:309-318
The disposition of XV459, a potent, selective GP IIb/IIIa antagonist, has been examined following intravenous administration of XP280, the benzenesulphonate salt, and 3H-SA202, the trifluroacetic acid salt, to male guinea pigs. A liquid chromatograph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98589126443bc34ceae901e5a5b625f
https://doi.org/10.1002/(sici)1099-081x(199909)20:6<309::aid-bdd190>3.0.co
https://doi.org/10.1002/(sici)1099-081x(199909)20:6<309::aid-bdd190>3.0.co
Autor:
Dennis M. Garner, Vanessa C. Peterman, Henry J. Pieniaszek, John E. Gray, Bernice L. Brogdon, Chii-Ming Lai
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 17:427-434
A simple, specific, and sensitive high-performance liquid chromatographic (HPLC) assay utilizing ultraviolet (UV) detection for the determination of bisnafide in human plasma was developed, validated, and applied to plasma samples from patients under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ded7a79f0253d743de7f50c06f45c8
https://doi.org/10.1016/s0731-7085(97)00232-x
https://doi.org/10.1016/s0731-7085(97)00232-x
Autor:
G. M. Lubiniecki, Seamus O'Reilly, Sharyn D. Baker, J. E. Gray, Ross C. Donehower, Henry J. Pieniaszek, M. Finizio, Eric K. Rowinsky, Louise B. Grochow, S E Sartorius
Publikováno v:
Annals of Oncology. 9:101-104
Summary Purpose: DMP 840, a novel bisnaphthalimide, has demonstrated promising schedule dependent anti-tumor activity in vitro and in vivo against several tumor cell lines. A phase I study was conducted to evaluate the effect of a 24-hour infusion sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79bf407f5fcc44d5f1c59e1b41c0147
https://doi.org/10.1023/a:1008260515869
https://doi.org/10.1023/a:1008260515869
Autor:
Anna F. Davidson, Linyee Shum, Paul J. Widner, Irma H. Benedek, Henry J. Pieniaszek, Walter Flamenbaum, Cynthia A. Robinson
Publikováno v:
The Journal of Clinical Pharmacology. 36:1161-1168
Sixteen healthy male volunteers completed a nonrandomized, sequential, three-phase study. The three phases were 1) moricizine at 250 mg every 8 hours for 7 days with 12 days washout; 2) diltiazem at 60 mg every 8 hours for 7 days; and 3) concomitant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e7ed0a70c49188cd06eb35db058dbb
https://doi.org/10.1002/j.1552-4604.1996.tb04171.x
https://doi.org/10.1002/j.1552-4604.1996.tb04171.x
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 14:1717-1725
A sensitive and specific high-performance liquid chromatographic method with electrochemical detection was developed for the simultaneous determination of naltrexone and its major metabolite, 6-beta-naltrexol, in human plasma. After alkalinizing 2 ml
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346d177571f40cbcc86c128f3cf36018
https://doi.org/10.1016/0731-7085(96)01794-3
https://doi.org/10.1016/0731-7085(96)01794-3