Zobrazeno 1 - 10
of 328
pro vyhledávání: '"Henry J. Duff"'
Autor:
Anna Janz, Katharina Walz, Alexandra Cirnu, Jessica Surjanto, Daniela Urlaub, Miriam Leskien, Michael Kohlhaas, Alexander Nickel, Theresa Brand, Naoko Nose, Philipp Wörsdörfer, Nicole Wagner, Takahiro Higuchi, Christoph Maack, Jan Dudek, Kristina Lorenz, Eva Klopocki, Süleyman Ergün, Henry J. Duff, Brenda Gerull
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101859- (2024)
Background: Dilated cardiomyopathy with ataxia (DCMA) is an autosomal recessive disorder arising from truncating mutations in DNAJC19, which encodes an inner mitochondrial membrane protein. Clinical features include an early onset, often life-threate
Externí odkaz:
https://doaj.org/article/6548eb7053f84f48be1c05ed1eeff5e5
Autor:
Williams E. Miranda, Jiqing Guo, Haydee Mesa-Galloso, Valentina Corradi, James P. Lees-Miller, D. Peter Tieleman, Henry J. Duff, Sergei Yu. Noskov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity. Here, the authors combine molecular dynamics simulations, mutagenesis, and electrophysiol
Externí odkaz:
https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b054
Autor:
Anna Janz, Ruping Chen, Martina Regensburger, Yuichiro Ueda, Simone Rost, Eva Klopocki, Katharina Günther, Frank Edenhofer, Henry J. Duff, Süleyman Ergün, Brenda Gerull
Publikováno v:
Stem Cell Research, Vol 46, Iss , Pp 101856- (2020)
Dilated cardiomyopathy with ataxia (DCMA) is an autosomal recessive disorder arising from mutations in DNAJC19. Two patient-derived dermal fibroblast cell lines of siblings with the same homozygous splice acceptor site mutation in DNAJC19 (NM_145261.
Externí odkaz:
https://doaj.org/article/c63e0dec29754f9790696a6e39d6f9e8
Autor:
Meruyert Kudaibergenova, Jiqing Guo, Hanif M. Khan, Farhan Zahid, James Lees-Miller, Sergei Yu. Noskov, Henry J. Duff
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Human-ether-a-go-go-related channel (hERG1) is the pore-forming domain of the delayed rectifier K+ channel in the heart which underlies the IKr current. The channel has been extensively studied due to its propensity to bind chemically diverse group o
Externí odkaz:
https://doaj.org/article/879c8e1fbdac4643966727b7d6174254
Autor:
Meruyert Kudaibergenova, Jiqing Guo, Hanif M. Khan, James Lees-Miller, Mahdi Mousaei, Williams Miranda, Van A. Ngo, Sergei Yu Noskov, D. Peter Tieleman, Henry J. Duff
Publikováno v:
Biophysical Journal. 121:4585-4599
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::895d852b87ba1d2943131dcfe5ebfb59
https://doi.org/10.1016/j.bpj.2022.10.032
https://doi.org/10.1016/j.bpj.2022.10.032
Autor:
Laura L. Perissinotti, Pablo M. De Biase, Jiqing Guo, Pei-Chi Yang, Miranda C. Lee, Colleen E. Clancy, Henry J. Duff, Sergei Y. Noskov
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
IKr is the rapidly activating component of the delayed rectifier potassium current, the ion current largely responsible for the repolarization of the cardiac action potential. Inherited forms of long QT syndrome (LQTS) (Lees-Miller et al., 1997) in h
Externí odkaz:
https://doaj.org/article/55a6b48ac7ca4144877062bf442031c9
Autor:
Joslyn Jung, Soren Wacker, Andrew D. Fant, Jiqing Guo, Williams E. Miranda, Mary Kudaibergenova, Sergei Y. Noskov, Henry J. Duff, Lei Shi, Andy Guan, Jianjing Cao, Kuo Hao Lee, Amy Hauck Newman, Therese Ku
Publikováno v:
J Chem Inf Model
Psychostimulant drugs, such as cocaine, inhibit dopamine reuptake via blockading the dopamine transporter (DAT), which is the primary mechanism underpinning their abuse. Atypical DAT inhibitors are dissimilar to cocaine and can block cocaine- or meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2210ef7eba1109d021c6032ff145c0da
https://doi.org/10.1021/acs.jcim.1c00856
https://doi.org/10.1021/acs.jcim.1c00856
Autor:
Henry J. Duff, James P. Lees-Miller, Valentina Corradi, Jiqing Guo, Williams E. Miranda, Haydee Mesa-Galloso, D. Peter Tieleman, Sergei Y. Noskov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity in various cell types. In this work, we combine molecular dynamics simulations, mutagenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ebaa10fb709ec926051bfcce623e66
https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b054
https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b054
Autor:
Martin S. Green, Joseph Atallah, Rafik Tadros, Julia Cadrin-Tourigny, Shane Kimber, Christian Steinberg, Bhavanesh Makanjee, Wael Alqarawi, Laura Arbour, Vuk Vuksanovic, Christopher S. Simpson, Zachary Laksman, Jeff S. Healey, Henry J. Duff, Jacqueline Joza, Stephanie Clarke, Anne Fournier, Ciorsti MacIntyre, Brianna Davies, Colette M. Seifer, Karen Gibbs, Shubhayan Sanatani, James McKinney, Paul Angaran, Richard Leather, Mario Talajic, Andrew D. Krahn, Robert J. Hamilton, Martin J. Gardner, Jason D. Roberts
Publikováno v:
CJC Open, Vol 2, Iss 6, Pp 652-662 (2020)
CJC Open
CJC Open
Background: The Hearts in Rhythm Organization (HiRO) is a team of Canadian inherited heart rhythm and cardiomyopathy experts, genetic counsellors, nurses, researchers, patients, and families dedicated to the detection of inherited arrhythmias and car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd2b6142650894902a3cfaaf5b8cd17
http://www.sciencedirect.com/science/article/pii/S2589790X20300652
http://www.sciencedirect.com/science/article/pii/S2589790X20300652
Autor:
Henry J. Duff, Jameson A. Dundas, Daniyil A. Svystonyuk, D. Park, Guoqi Teng, Simranjit S. Pattar, Subodh Verma, Darrell D. Belke, Jason R.B. Dyck, Paul W.M. Fedak, Ryan H. Cunnington, Sean Kang, David G. Guzzardi, Jeannine D. Turnbull, Ali Fatehi Hassanabad, Lee Anne Tibbles
Publikováno v:
Canadian Journal of Cardiology. 36:543-553
Background Empagliflozin, an SGLT2 inhibitor, has shown remarkable reductions in cardiovascular mortality and heart failure admissions (EMPA-REG OUTCOME). However, the mechanism underlying the heart failure protective effects of empagliflozin remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5459201faee52fe54961c8a92e16afc4
https://doi.org/10.1016/j.cjca.2019.08.033
https://doi.org/10.1016/j.cjca.2019.08.033