Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Henry J Benns"'
Autor:
Corinna Benz, Winston Lo, Nadin Fathallah, Ashley Connor-Guscott, Henry J Benns, Michael D Urbaniak
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0206332 (2018)
The bloodstream form of the parasite Trypanosoma brucei obtains iron from its mammalian host by receptor-mediated endocytosis of host transferrin through its own unique transferrin receptor (TbTfR). Expression of TbTfR rapidly increases upon iron sta
Externí odkaz:
https://doaj.org/article/ec998cf796974eb99ada3eec3e5a57ac
Publikováno v:
Current Opinion in Chemical Biology. 60:20-29
Activity-based protein profiling (ABPP) is recognized as a powerful and versatile chemoproteomic technology in drug discovery. Central to ABPP is the use of activity-based probes to report the activity of specific enzymes or reactivity of amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec62b9087b27c16b9beea787ad7ef08
https://doi.org/10.1016/j.cbpa.2020.06.011
https://doi.org/10.1016/j.cbpa.2020.06.011
Autor:
Ceire J, Wincott, Gayathri, Sritharan, Henry J, Benns, Dana, May, Carla, Gilabert-Carbajo, Monique, Bunyan, Aisling R, Fairweather, Eduardo, Alves, Ivan, Andrew, Laurence, Game, Eva-Maria, Frickel, Calvin, Tiengwe, Sarah E, Ewald, Matthew A, Child
Publikováno v:
Cell reports methods. 2(8)
Cellular barcoding techniques are powerful tools to understand microbial pathogenesis. However, barcoding strategies have not been broadly applied to protozoan parasites, which have unique genomic structures and virulence strategies compared with vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4646c83f1dcc96fe089560f794b1241
https://pubmed.ncbi.nlm.nih.gov/36046624
https://pubmed.ncbi.nlm.nih.gov/36046624
Autor:
Ceire J. Wincott, Gayathri Sritharan, Henry J. Benns, Farzana B. Liakath, Carla Gilabert-Carbajo, Monique Bunyan, Aisling R. Fairweather, Eduardo Alves, Ivan Andrew, Laurence Game, Eva M. Frickel, Calvin Tiengwe, Sarah E. Ewald, Matthew A. Child
Molecular barcoding techniques have emerged as powerful tools to understand microbial pathogenesis. However, barcoding strategies have not been extended to protozoan parasites, which have unique genomic structures and virulence strategies compared to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e48515ef71998e8a50da733382ffbfc
Autor:
Eduardo Alves, Henry J. Benns, Lilian Magnus, Caia Dominicus, Tamás Dobai, Joshua Blight, Ceire J. Wincott, Matthew A. Child
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The ability of an organism to sense and respond to environmental redox fluctuations relies on a signaling network that is incompletely understood in apicomplexan parasites such as Toxoplasma gondii. The impact of changes in redox upon the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b557e9da54d5f5a961f54e07af1cba
https://doi.org/10.3389/fcimb.2021.728425
https://doi.org/10.3389/fcimb.2021.728425
Autor:
Julia A Falco, Eduardo Q. Alves, Jake Baum, Eranthie Weerapana, Geoff S. Baldwin, Henry J Benns, Edward W. Tate, Matthew A. Child, Fabio R. Fisher, Marko Storch, Ceire Joanna Wincott
SummaryNucleophilic amino acids are important in covalent drug development yet underutilized as antimicrobial targets. Over recent years, several chemoproteomic technologies have been developed to mine chemically-accessible residues via their intrins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b45a2d740a1402acd86d9b466650c303
https://doi.org/10.1101/2021.02.04.429737
https://doi.org/10.1101/2021.02.04.429737
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 6, Pp n/a-n/a (2020)
Molecular Systems Biology
Molecular Systems Biology
Rational molecular engineering of proteins with CRISPR‐based approaches is challenged by the gene‐centric nature of gRNA design tools. To address this, we have developed CRISPR‐TAPE, a protein‐centric gRNA design algorithm that allows users t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc837f923cc6e46d174a9caf6f323cf
https://doi.org/10.15252/msb.20209475
https://doi.org/10.15252/msb.20209475
Rational molecular engineering of proteins with CRISPR-based approaches is challenged by the gene-centric nature of gRNA design tools. To address this, we have developed CRISPR-TAPE, a protein-centric gRNA design algorithm that allows users to target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a56851d5d05e5180be54959aaf414f
https://doi.org/10.1101/2020.02.26.965889
https://doi.org/10.1101/2020.02.26.965889
Publikováno v:
Current topics in microbiology and immunology. 420
Parasites exist within most ecological niches, often transitioning through biologically and chemically complex host environments over the course of their parasitic life cycles. While the development of technologies for genetic engineering has revolut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e6e6c65ee1f0442e8152e59b570545f
https://pubmed.ncbi.nlm.nih.gov/30105424
https://pubmed.ncbi.nlm.nih.gov/30105424
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783030111427
Parasites exist within most ecological niches, often transitioning through biologically and chemically complex host environments over the course of their parasitic life cycles. While the development of technologies for genetic engineering has revolut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2cf22bb0931105422a90e6696a1de55
https://doi.org/10.1007/82_2018_123
https://doi.org/10.1007/82_2018_123