Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Henry J, Klamut"'
Autor:
Tiffany Krushel, Carlo Bastianutto, Nehad M. Alajez, Henry J. Klamut, Fei-Fei Liu, Abby Leung, Kwok W. Lo, Marie C. Chia, Philippe Busson
Publikováno v:
Clinical Cancer Research. 14:984-994
Purpose: The Epstein Barr virus (EBV) is intimately associated with nasopharyngeal cancer (NPC) in a latent state expressing a limited number of genes. The process of switching from latency to replication is not well understood, particularly in respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bb03330d9075e7c934755340b4a727
https://doi.org/10.1158/1078-0432.ccr-07-0828
https://doi.org/10.1158/1078-0432.ccr-07-0828
Publikováno v:
Critical Reviews in Eukaryotic Gene Expression. 14:89-136
Skeletal gene therapy is an attractive new approach to the treatment of bone disorders. Impressive advances in our knowledge of the molecular genetic basis of skeletal disorders and fracture healing have led to the development of novel therapeutics b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3820533932d80de50fc58c6afc35b3ba
https://doi.org/10.1615/critreveukaryotgeneexpr.v14.i12.60
https://doi.org/10.1615/critreveukaryotgeneexpr.v14.i12.60
Autor:
Peter C. Neligan, Marie Chia, Jeffrey A. Medin, Henry J. Klamut, Patrick J. Gullane, Wei Shi, Philippe Busson, Brian O'Sullivan, Jian-Hua Li, Otto Sanchez-Sweatman, Dolly P. Huang, Fei-Fei Liu, Christopher Siatskas, Wen-Chen Yeh, Chris Richardson
Publikováno v:
Molecular Therapy. 8(6):964-973
We have successfully achieved selective gene expression in human nasopharyngeal carcinoma (NPC) by exploiting the presence of the Epstein–Barr virus (EBV), utilizing a transcriptional targeting strategy (J. H. Li et al., 2002, Cancer Res. 62: 171).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d4566805b3492a4d1a907f5cf6ca51
Publikováno v:
Cancer Gene Therapy. 10:294-301
Adjuvant hyperthermia can improve treatment outcome for locally recurrent breast cancer (LRBC). Previously, we demonstrated that infection of human breast cancer cells with a recombinant adenovirus expressing beta-galactosidase from the human hsp70b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c03f4cf1498ab06d0ebea501f4439c
https://doi.org/10.1038/sj.cgt.7700570
https://doi.org/10.1038/sj.cgt.7700570
Publikováno v:
Clinical Orthopaedics and Related Research. 401:88-106
The cloning of the dystrophin gene has led to major advances in the understanding of the molecular genetic basis of Duchenne, Becker, and other muscular dystrophies associated with mutations in genes encoding members of the dystrophin-associated glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1434fd5ef9084c746b0c30272b821c7
https://doi.org/10.1097/00003086-200208000-00012
https://doi.org/10.1097/00003086-200208000-00012
Publikováno v:
Cancer Gene Therapy. 9:209-217
Intratumoral injection of recombinant adenoviral type 5 (Ad5) vectors that carry prodrug-activating enzymes like DT-diaphorase (DTD) could be used to selectively target tumor cells for chemotherapy. To demonstrate the feasibility of this approach, Ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9adcf77330e015faefa0acfd91d4ccba
https://doi.org/10.1038/sj.cgt.7700430
https://doi.org/10.1038/sj.cgt.7700430
Publikováno v:
Cancer Gene Therapy. 7:1566-1574
Targeting therapeutic gene expression to tumor cells represents a major challenge for cancer gene therapy. The strong transcriptional response exhibited by heat shock genes, along with the beneficial therapeutic effects of hyperthermia have led us to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0649ef65032de60514c041c3679431
https://doi.org/10.1038/sj.cgt.7700267
https://doi.org/10.1038/sj.cgt.7700267
Autor:
Richard C. Austin, Jeffrey V. Wong, Anthony Brade, Henry J. Klamut, Cheryl H. Arrowsmith, Pei-Xiang Li, Ayeda Ayed, Duc Ngo
Publikováno v:
Journal of Biological Chemistry. 275:20127-20135
The p53 tumor suppressor gene and members of the transforming growth factor-beta (TGF-beta) superfamily play central roles in signaling cell cycle arrest and apoptosis (programmed cell death) in normal development and differentiation, as well as in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2073d07cc27bcc8a9076ce93854753
https://doi.org/10.1074/jbc.m909580199
https://doi.org/10.1074/jbc.m909580199
Publikováno v:
Neuromuscular Disorders. 10:187-193
Transcripts encoding the 70-75 kDa C-terminal protein product of the dystrophin gene (Dp71) are alternatively spliced to generate multiple protein products in a number of adult human tissues. In this report, reverse transcriptase-polymerase chain rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a068faca0f95ec2a0ea359718515ea
https://doi.org/10.1016/s0960-8966(99)00105-4
https://doi.org/10.1016/s0960-8966(99)00105-4
Autor:
Dolly P. Huang, Jian-Hua Li, Xianghe Zhang, Bao-Fu Sun, Fei-Fei Liu, Henry J. Klamut, Jaap M. Middeldorp
Publikováno v:
International Journal of Cancer. 87:606-610
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19d908b1c86842b7bfeca3dcdbbb085b
https://doi.org/10.1002/1097-0215(20000815)87:4<606::aid-ijc23>3.0.co
https://doi.org/10.1002/1097-0215(20000815)87:4<606::aid-ijc23>3.0.co