Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Henry I, Mosberg"'
Autor:
Traynor, Deanna Montgomery, Hartman Jg, Henry I. Mosberg, Sánchez-Santiago Aa, Nicholas W. Griggs, Jessica P. Anand, Thomas J Fernandez, Irina D. Pogozheva
Publikováno v:
ACS Chemical Neuroscience. 10:3682-3689
The dimethyltyrosine–tetrahydroisoquinoline (Dmt-Tiq) scaffold was originally developed in the production of selective delta opioid receptor (DOR) antagonists. Installation of a 7-benzyl pendant on...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::179acd152579ad14ee6a988ea61d1c51
https://doi.org/10.1021/acschemneuro.9b00250
https://doi.org/10.1021/acschemneuro.9b00250
Autor:
Aaron M. Bender, Thomas J Fernandez, John R. Traynor, Emily M. Jutkiewicz, Henry I. Mosberg, Nicholas W. Griggs, Jessica P. Anand, Anthony F. Nastase, Deanna Montgomery
Publikováno v:
Journal of Medicinal Chemistry. 62:4193-4203
Short-acting μ-opioid receptor (MOR) agonists have long been used for the treatment of severe, breakthrough pain. However, selective MOR agonists including fentanyl and morphine derivatives are limited clinically due to high risks of dependence, tol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfc327b5a0e52c3aca3e632834c3510
https://doi.org/10.1021/acs.jmedchem.9b00378
https://doi.org/10.1021/acs.jmedchem.9b00378
Autor:
Christian E. Loo, Sean Henry, Henry I. Mosberg, John R. Traynor, Jessica P. Anand, Douglas M. McMillan, Ashley C. Brinkel, Jack. J. Twarozynski
Publikováno v:
ACS Chem Neurosci
We previously described the development of potent μ-opioid receptor (MOR)-agonist/δ-opioid receptor (DOR)-antagonist peptidomimetic ligands as an approach toward effective analgesics with reduced side effects. In this series, a tetrahydroquinoline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8ad5db979cea94c9bf96191fc5d796
https://europepmc.org/articles/PMC9923772/
https://europepmc.org/articles/PMC9923772/
Autor:
Irina D. Pogozheva, Ashley C. Brinkel, John R. Traynor, Emily M. Jutkiewicz, Bryan F. Sears, Sean Henry, Henry I. Mosberg, Jack. J. Twarozynski, Jessica P. Anand
Publikováno v:
J Med Chem
We previously reported a novel SAR campaign that converted a metabolically unstable series of μ-opioid receptor (MOR) agonist/ δ-opioid receptor (DOR) antagonist bicyclic core peptidomimetics with promising analgesic activity and reduced abuse liab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e26c4540c421240c41fe12fc28ea2ea
https://europepmc.org/articles/PMC7047604/
https://europepmc.org/articles/PMC7047604/
Autor:
Emily M. Jutkiewicz, Nicholas W. Griggs, Henry I. Mosberg, Jessica P. Anand, Anthony F. Nastase, Deanna Montgomery, Kelsey E Kochan, John R. Traynor
Publikováno v:
British Journal of Pharmacology. 175:2013-2027
BACKGROUND AND PURPOSE Agonists at μ-opioid receptors (μ-receptors) are used for pain management but produce adverse effects including tolerance, dependence and euphoria. The co-administration of a μ-receptor agonist with a δ-opioid receptor (δ-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ca42222ac9170fc7afdba2255cc86f
https://doi.org/10.1111/bph.14148
https://doi.org/10.1111/bph.14148
Autor:
Anthony F. Nastase, Jessica P. Anand, Tyler J. Trask, Henry I. Mosberg, Emily M. Jutkiewicz, Thomas J Fernandez, Nicholas W. Griggs, John R. Traynor, Aubrie A. Harland
Publikováno v:
ACS Chem Neurosci
The use of opioids for the treatment of pain, while largely effective, is limited by detrimental side effects including analgesic tolerance, physical dependence, and euphoria, which may lead to opioid abuse. Studies have shown that compounds with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2aa9cd90a3cb78894dd62220fff74cb
https://doi.org/10.1021/acschemneuro.8b00139
https://doi.org/10.1021/acschemneuro.8b00139
Autor:
Henry I. Mosberg, Aubrie A. Harland, Irina D. Pogozheva, Nicholas W. Griggs, John R. Traynor, Tyler J. Trask
Publikováno v:
ACS Chemical Neuroscience
In an effort to expand the structure–activity relationship (SAR) studies of a series of mixed-efficacy opioid ligands, peptidomimetics that incorporate methoxy and hydroxy groups around a benzyl or 2-methylindanyl pendant on a tetrahydroquinoline (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60a19333a22d3ae99d697cda0dce990
https://doi.org/10.1021/acschemneuro.7b00284
https://doi.org/10.1021/acschemneuro.7b00284
Autor:
Carrie Haskell-Luevano, Zoe M. Koerperich, Katie T. Freeman, Henry I. Mosberg, Robert C. Speth, Irina D. Pogozheva, Mark D. Ericson
Publikováno v:
J Med Chem
While the melanocortin receptors (MCRs) are known to be involved in numerous biological pathways, the potential roles of the MC5R have not been clearly elucidated in humans. Agouti-related protein (AgRP), an MC3R/MC4R antagonist and MC4R inverse agon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da29e42d68557b570746ed4fa701025d
https://europepmc.org/articles/PMC7250496/
https://europepmc.org/articles/PMC7250496/
Autor:
Delong Lj, Hartman Jg, Traynor, Jessica P. Anand, Deanna Montgomery, Baber Ma, Jack. J. Twarozynski, Henry I. Mosberg
Publikováno v:
Molecules
Volume 24
Issue 23
Volume 24
Issue 23
The opioid receptors modulate a variety of biological functions, including pain, mood, and reward. As a result, opioid ligands are being explored as potential therapeutics for a variety of indications. Multifunctional opioid ligands, which act simult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b15f94804488409c30a270f96184f43