Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Henry Holzgrefe"'
Autor:
Icilio Cavero, Henry Holzgrefe
Publikováno v:
Advances in Physiology Education. 46:549-579
The mammalian cardiac conduction system (CCS) is a multifaceted continuum of electrically distinct, interconnected constructs within the myocardial mass. The key components are the sinus node (SAN), the atrioventricular node (AVN), the His bundle (HB
Publikováno v:
Journal of pharmacological and toxicological methods. 115
Pending updates to ICH S7B/E14 guidelines will enable the substitution of human TQT studies with support from concomitant negative hERG and non-rodent CV studies. This retrospective analysis compared the effects of thioridazine (THD) (5-20 mg/kg) on
Autor:
Muriel Saulnier, Theodore J. Baird, Pascal Champeroux, Masaki Honda, Michael Gill, Henry Holzgrefe, Georg Ferber, Olivier Meyer, Andrea Greiter-Wilke
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 69(1):61-101
Introduction In vivo models have been required to demonstrate relative cardiac safety, but model sensitivity has not been systematically investigated. Cross-species and human translation of repolarization delay, assessed as QT/QTc prolongation, has n
Publikováno v:
Journal of Electrocardiology. 46:118-125
Background and Purpose Machine-read QT measurements employing T-wave detection algorithms (ALG) are not accepted by regulatory agencies for the primary analysis of thorough QT (TQT) studies. Newly developed pattern recognition software (PRO) which ma
Autor:
Georg Ferber, Olivier Meyer, Royce A. Morrison, Henry Holzgrefe, Andrea Greiter-Wilke, Thomas Singer
Publikováno v:
The Journal of Clinical Pharmacology. 52:1222-1239
The authors have previously demonstrated rate-independent QT variability in the dog and cynomolgus monkey, where the QT associated with any RR was a normally distributed value that was accurately evaluated as the distribution mean. The present study
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:230
Autor:
Icilio, Cavero, Henry, Holzgrefe
Publikováno v:
Expert opinion on drug safety. 13(6)
The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a novel safety screening proposal intended to replace the 2005 regulatory strategy recommended by the International Conference of Harmonization S7B guideline.CiPA consists of three components.
Autor:
Stephen D. Tichenor, Robert Kaiser, Brittany Lilly, Henry Holzgrefe, Douglas E. Regalia, Angela Wilcox
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 81:370
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 75:174
Publikováno v:
Journal of Electrocardiology. 46:717.e1-717.e9
Background and Purpose Technological advances in machine-read QT measurement now enable detailed and precise cardiac repolarization assessments. This study assessed the applicability of three state-of-art ECG measurement applications to provide relia