Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Henry Furneaux"'
Autor:
Youxi Ai, Ming-Tao Wu, Ari Ristimäki, Timothy Hla, Hector L. Aguila, Caiying Guo, Mallika Ghosh, Jason Michaud, Henry Furneaux, Annabrita Hemmes
Publikováno v:
Journal of Clinical Investigation. 119:3530-3543
The RNA-binding protein HuR (also known as ELAV1) binds to the 3′-untranslated region of mRNAs and regulates transcript stability and translation. However, the in vivo functions of HuR are not well understood. Here, we report that murine HuR is ess
Publikováno v:
Journal of Biological Chemistry. 282:32773-32779
MicroRNAs are short, single-stranded RNAs that arise from a transient precursor duplex. We have identified a novel activity in HeLa cell extracts that can unwind the let-7 microRNA duplex. Using partially purified material, we have shown that microRN
Autor:
Henry Furneaux, Takiko Daikoku, Anindita Chakrabarty, Sudhansu K. Dey, Kevin P. Jensen, Susanne Tranguch
Publikováno v:
Proceedings of the National Academy of Sciences. 104:15144-15149
The implantation process is complex, requiring reciprocal interactions between implantation-competent blastocysts and the receptive uterus. Because microRNAs (miRNAs) have major roles in regulating gene expression, we speculated that they participate
Publikováno v:
Molecular Endocrinology. 21:1132-1147
Micro-RNAs are small noncoding RNAs, which diminish the stability and/or translation of mRNAs. This study examined whether miR-206, previously shown to be elevated in estrogen receptor (ER)alpha-negative breast cancer, regulates the expression of ERa
Autor:
Justin D. Blethrow, Henry Furneaux, Rudolf Pullmann, Ashish Lal, Kotb Abdelmohsen, David A. F. Gillespie, Xiaoling Yang, Stefanie Galbán, Mark Walker, Myriam Gorospe, Hyeon Ho Kim, Jonathan Shubert
Publikováno v:
Molecular Cell. 25(4):543-557
The RNA binding protein HuR regulates the stability of many target mRNAs. Here, we report that HuR associated with the 3' untranslated region of the mRNA encoding the longevity and stress-response protein SIRT1, stabilized the SIRT1 mRNA, and increas
Autor:
Caj Haglund, Anna Sivula, Henry Furneaux, Mira Heinonen, Heini Lassus, Tiina-Liisa Erkinheimo, Ari Ristimäki, Ralf Bützow
Publikováno v:
Gynecologic Oncology. 99:14-19
Cyclooxygenase-2 (COX-2) expression has been found to associate with poor prognosis in several types of carcinomas. HuR is an mRNA stability protein and it regulates the expression of COX-2. Objectives and methods. We analyzed the expression of COX-2
Autor:
Henry Furneaux, Heikki Joensuu, Caj Haglund, Johan Lundin, Mira Heinonen, Timothy Hla, Sung-Hee Chang, Petri Bono, Kirsi Narko, Ari Ristimäki
Publikováno v:
Cancer Research. 65:2157-2161
HuR is a ubiquitously expressed mRNA-binding protein. Intracellular localization of HuR is predominantly nuclear, but it shuttles between the nucleus and the cytoplasm. In the cytoplasm it can stabilize certain transcripts. Because nucleocytoplasmic
Autor:
Gary J. Bassell, Catherine L. Smith, Nora I. Perrone-Bizzozero, Henry Furneaux, Rownak Afroz, Richard W. Burry
Publikováno v:
Journal of Neurobiology. 61:222-235
The neuron-specific ELAV/Hu family member, HuD, interacts with and stabilizes GAP-43 mRNA in developing neurons, and leads to increased levels of GAP-43 protein. As GAP-43 protein is enriched in growth cones, it is of interest to determine if HuD and
Publikováno v:
Journal of Neurochemistry. 86:763-773
Many genes governed by thyroid hormone (T3) lack binding sites for its receptor (TR) and are thought to be post-transcriptionally regulated by T3. Here we demonstrate that the HuD gene, which encodes a neurone-specific protein that binds to mRNA and
Autor:
Henry Furneaux, Keith M. Giles, Andrew M. Thomson, Dominic C. Voon, John M. Daly, Dianne J. Beveridge, Peter J. Leedman, Jalal A. Jazayeri
Publikováno v:
Journal of Biological Chemistry. 278:2937-2946
Despite promoting growth in many cell types, epidermal growth factor (EGF) induces growth inhibition in a variety of cancer cells that overexpress its receptor. The cyclin-dependent kinase inhibitor p21(WAF1) is a central component of this pathway. W