Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Henry Forward"'
Autor:
Andrew J. Ratcliffe, Nicola Ooi, Neil R. Stokes, Richard Metzger, Victoria J. Savage, Henry Forward, David McGarry, Emmanuel Moyo, Cedric Charrier, Jonathan Cheung, Rolf Peter Walker, Ian R. Cooper, Anne-Marie Salisbury
Publikováno v:
Journal of Antimicrobial Chemotherapy. 71:2831-2839
OBJECTIVES: To evaluate the in vitro biological properties of a novel class of isothiazolone inhibitors of the bacterial type II topoisomerases. METHODS: Inhibition of DNA gyrase and topoisomerase IV activity was assessed using DNA supercoiling and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b43f52e1ea3e514df62ad0be38b1aa
https://doi.org/10.1093/jac/dkw228
https://doi.org/10.1093/jac/dkw228
Autor:
Gary Nelson, Henry Forward, David McGarry, Jonathan Cheung, Andrew J. Ratcliffe, James Kirkham, Mark Craighead, Cedric Charrier, Zoe Gault, Ian R. Cooper, Catherine E. Warrilow, John Maclean, Emmanuel Moyo, Neil R. Stokes, Andrew J. McCarroll, Anne-Marie Salisbury, Victoria J. Savage, Mark Pichowicz, Stuart A. Best, Diarmaid Hughes, Rolf Peter Walker, Richard Metzger, Sha Cao
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(17)
There is an urgent and unmet medical need for new antibacterial drugs that tackle infections caused by multidrug-resistant (MDR) pathogens. During the course of our wider efforts to discover and exploit novel mechanism of action antibacterials, we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784efa1acabfb498190a7bff89f4ca76
https://pubmed.ncbi.nlm.nih.gov/27499455
https://pubmed.ncbi.nlm.nih.gov/27499455
Autor:
Nathan Chaffer-Malam, Mario Uosis-Martin, Henry Forward, Stuart A. Best, Ralph Kirk, Andrew J. Ratcliffe, Richard Metzger, Neil R. Stokes, Gary M. Noonan, Victoria J. Savage, Anne-Marie Salisbury, Cedric Charrier, Sarfraz Mohmed, Anthony Huxley, Emmanuel Moyo
Publikováno v:
The Journal of antimicrobial chemotherapy. 71(7)
Objectives The objective of this study was to characterize the in vitro and in vivo biological properties of a novel series of small-molecule bacterial type IIA topoisomerase inhibitors. Methods Bacterial susceptibility testing was performed by broth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770f84ca9630ffd1ec1cb7b32f6ceff5
https://pubmed.ncbi.nlm.nih.gov/27032669
https://pubmed.ncbi.nlm.nih.gov/27032669