Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Henry E. Holden"'
Publikováno v:
Toxicologic Pathology. 27:501-506
Oxymetholone is generally assumed to be a nongenotoxic carcinogen. This assumption is based primarily on the results of an Ames test, existing data in repeat-dose toxicology studies, and the predicted results of a 2-yr National Toxicology Program (NT
Publikováno v:
Toxicologic Pathology. 27:507-512
Several rodent models are under examination as possible alternatives to the classical 2-yr carcinogenicity bioassay. The Tg.AC transgenic mouse has been proposed as a shorter term model offering the possibility of detecting nongenotoxic and genotoxic
Publikováno v:
Environmental and Molecular Mutagenesis. 32:192-196
The spontaneous and induced revertant frequency of four Salmonella typhimurium strains (TA1535, TA1537, TA98, and TA100) and Escherichia coli [WP2 uvrA (pKM101)] was evaluated using Vogel Bonner minimal plates prepared with ten different agars. In ad
Autor:
Jenness B. Majeska, Henry E. Holden
Publikováno v:
Environmental and Molecular Mutagenesis. 23:150-154
Autor:
Austin J. Joyce, Margitta G. Wahrenburg, Paula A. Muehlbauer, Verne A. Ray, Henry E. Holden, Gail N. Turner, David E. Amacher, John H. Ellis
Publikováno v:
Mutation Research/Genetic Toxicology. 300:79-90
Azithromycin was subjected to a series of three in vitro and one in vivo genetic toxicology assays for the detection of drug-associated gene or chromosomal effects. In the Ames Salmonella typhimurium tester strains TA1535, TA1537, TA98 and TA100, the
Publikováno v:
Environmental and Molecular Mutagenesis. 16:311-319
In previously described activation systems [Clive D, Spector JFS (1975): Mutat Res 31:17-29] for the mouse lymphoma mutation assay the cofactor isocitrate is rapidly exhausted and the resultant loss of NADPH can halt metabolic processes. Presented he
Autor:
Curt H. Barthel, Kerry T. Blanchard, Henry E. Holden, Roger Moretz, Raymond E. Stoll, John E. French, Franklin D. Pack, Raymond W. Tennant
Publikováno v:
Toxicologic pathology. 27(5)
Heterozygous p53 +/- transgenic mice are being studied for utility as a short-term alternative model to the 2-yr rodent carcinogenicity bioassay. During a 26-wk study to assess the potential carcinogenicity of oxymetholone using p-cresidine as a posi
Autor:
Sylvia M. Furst, James H. Stoltz, Kerry T. Blanchard, Raymond E. Stoll, Henry E. Holden, D. J. Ball
Publikováno v:
Toxicologic pathology. 26(4)
Assessment of the carcinogenic potential of chemical agents continues to rely primarily upon the chronic rodent bioassay, a resource-intensive exercise. Recent advances in transgenic technology offer a potential resource conserving approach to carcin
Publikováno v:
Mutation research. 391(1-2)
Rats and mice were treated concurrently with mitomycin C at a dose of 1 mg/kg/day i.p. for 3 days, a regimen known to induce micronuclei in polychromatic erythrocytes (MN-PCE) in the bone marrow of rats and mice and the peripheral blood of mice. The
Autor:
Henry E. Holden, Jenness B. Majeska
Publikováno v:
Environmental and molecular mutagenesis. 26(2)
p-Aminophenol (PAP), a metabolite of aniline and acetaminophen, has been reported to be mutagenic in the L5178Y mouse lymphoma assay, but not in the CHO/HGPRT assay. In the present study, the effects of PAP in these two cells lines were examined to d