Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Henry C M Leung"'
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114253 (2014)
Since the read lengths of high throughput sequencing (HTS) technologies are short, de novo assembly which plays significant roles in many applications remains a great challenge. Most of the state-of-the-art approaches base on de Bruijn graph strategy
Externí odkaz:
https://doaj.org/article/9ae0690a65ad42599be3f01b62fd6379
Autor:
Bone S.F. Tang, Yvonne Chung, Chun Hang Au, Dona N. Ho, Tsun Leung Chan, Elaine Yue Ling Wong, Wai Sing Chan, Edmond S. K. Ma, Tak-Wah Lam, Henry C. M. Leung
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-7 (2020)
BMC Research Notes
BMC Research Notes
Objective We designed and tested a Nanopore sequencing panel for direct tuberculosis drug resistance profiling. The panel targeted 10 resistance-associated loci. We assessed the feasibility of amplifying and sequencing these loci from 23 clinical spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a20ac2692db5f7824de8d9c4319f402
http://link.springer.com/article/10.1186/s13104-020-05287-9
http://link.springer.com/article/10.1186/s13104-020-05287-9
Autor:
Henry C. M. Leung, Huijing Yu, Yifan Zhang, Wing Sze Leung, Ivan F. M. Lo, Ho Ming Luk, Wai-Chun Law, Ka Kui Ma, Chak Lim Wong, Yat Sing Wong, Ruibang Luo, Tak-Wah Lam
Publikováno v:
Scientific Reports. 12
Structural variation (SV) is a major cause of genetic disorders. In this paper, we show that low-depth (specifically, 4×) whole-genome sequencing using a single Oxford Nanopore MinION flow cell suffices to support sensitive detection of SV, particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc66241773256d9e124ea3b8de566065
https://doi.org/10.1038/s41598-022-08576-4
https://doi.org/10.1038/s41598-022-08576-4
Autor:
Henry C. M. Leung, Wai-Sing Chan, Edmond S. K. Ma, Dinghua Li, Chun Hang Au, Dona N. Ho, Tak-Wah Lam, Bone S.F. Tang, T. K. Chan
Publikováno v:
Future Cardiology. 15:411-424
Aim: To explore potential utility of metagenomic sequencing for improving etiologic diagnosis of infective endocarditis (IE) caused by fastidious bacteria. Materials & methods: Plasma and heart valves of two patients, who were diagnosed with IE cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a70c635c5f7969a356d22e379adb19d
https://doi.org/10.2217/fca-2018-0088
https://doi.org/10.2217/fca-2018-0088
Autor:
Ruibang Luo, Zheng Z, Alan W. Leung, Lui W, Luk Hm, Tak-Wah Lam, Henry C. M. Leung, Chak-Lim Wong, Lo If
BackgroundThe application of long-read sequencing using the Oxford Nanopore Technologies (ONT) MinION sequencer is getting more diverse in the medical field. Having a high sequencing error of ONT and limited throughput from a single MinION flowcell,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07fa11d88dea0e668390518bba5fde3c
https://doi.org/10.1101/2021.04.05.438455
https://doi.org/10.1101/2021.04.05.438455
Autor:
Yan Xin, Patrick C. Y. Woo, Henry C. M. Leung, Tak-Wah Lam, Ruibang Luo, Wui Wang Lui, Jade L. L. Teng, Amy W. S. Leung
Publikováno v:
BIBM
Accurate and sensitive taxonomic profiling is essential for any metagenomic analysis to reveal microbial community structure and for potential functional prediction. Antimicrobial resistance (AMR) detection is also a critical task in the clinical dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c84e1bc6ab150a32e27f3e5c413c8f15
https://doi.org/10.1109/bibm49941.2020.9313313
https://doi.org/10.1109/bibm49941.2020.9313313
Publikováno v:
iScience, Vol 23, Iss 5, Pp-(2020)
iScience
iScience
Summary Single-molecule sequencing technologies produce much longer reads compared with next-generation sequencing, greatly improving the contiguity of de novo assembly of genomes. However, the relatively high error rates in long reads make it challe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea1af262803a5235dd0641bee0951a4
http://www.sciencedirect.com/science/article/pii/S2589004220303138
http://www.sciencedirect.com/science/article/pii/S2589004220303138
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783030170820
RECOMB
RECOMB
Over one million new biomedical articles are published every year. Efficient and accurate text-mining tools are urgently needed to automatically extract knowledge from these articles to support research and genetic testing. In particular, the extract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::627e401893638d903b64c33486102d05
https://doi.org/10.1007/978-3-030-17083-7_17
https://doi.org/10.1007/978-3-030-17083-7_17
Autor:
Edmond S. K. Ma, Wai-Sing Chan, T. K. Chan, Bone S.F. Tang, Henry C. M. Leung, Chun Hang Au, Dona N. Ho, Tak-Wah Lam
Publikováno v:
Microbiology Resource Announcements
Isolation of Helicobacter cinaedi from a positive blood culture requires prolonged and stringent subculture conditions. Direct whole-genome sequencing (WGS) of a positive blood culture may provide timely treatment-associated genetic information.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe9b665d9a0c996ae1d0f7d7dd4545e
http://europepmc.org/articles/PMC6256545
http://europepmc.org/articles/PMC6256545
Autor:
Johnny S. H. Kwan, Peikai Chen, Timothy Shin Heng Mak, Liqian Cui, Miaoxin Li, Henry C. M. Leung, Pak C. Sham, Lin Jiang, Tao Li, Chao Xue
Publikováno v:
Bioinformatics (Oxford, England). 35(4)
Motivation It remains challenging to unravel new susceptibility genes of complex diseases and the mechanisms in genome-wide association studies. There are at least two difficulties, isolation of the genuine susceptibility genes from many indirectly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ddc686e8ed87de7f3b5d609bc8bec2
https://pubmed.ncbi.nlm.nih.gov/30101339
https://pubmed.ncbi.nlm.nih.gov/30101339