Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Henry Bader"'
Publikováno v:
JAWRA Journal of the American Water Resources Association. 58:566-577
Publikováno v:
Journal of Medicinal Chemistry. 43:1620-1634
Seven Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine (2, PT523) analogues were synthesized by modifications of the literature synthesis of the corresponding AMT (1) analogues and were tested as inhibitors of tumor cell growth. In growth a
Publikováno v:
Pteridines, Vol 10, Iss 1, Pp 39-46 (1999)
L-2-(N-Pteroyl)amino-3-(N-phosphonoacetyl)aminopropanoic acid was synthesized as an analogue of the putative y-phosphorylated intermediate in the enzyme-catalyzed γ-glutamation of folic acid by folylpolyglutamate synthetase (FPGS). N-(Benzyloxycarbo
Autor:
Chitra M. Vaidya, Ronald A. Forsch, Andre Rosowsky, Clara E. Mota, Henry Bader, Joel E. Wright, Cindy S. Chen, Jorge Pardo, Ying-Nan Chen
Publikováno v:
Journal of Medicinal Chemistry. 41:5310-5319
Six new B-ring analogues of the nonpolyglutamatable antifolate Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine (PT523, 3) were synthesized with a view to determining the effect of modifications at the 5- and/or 8-position on dihydrofolate
Publikováno v:
Journal of Medicinal Chemistry. 40:286-299
Four heretofore undescribed side chain analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523, 4) were synthesized via straightforward methods of antifolate chemistry, and their properties were compared with those of P
Publikováno v:
Journal of Heterocyclic Chemistry. 31:1241-1250
1-[4-(tert-Butyloxycarbonyl)phenyl]-3-pyrrolidinone and 1-[3-(tert-butyloxycarbonyl)phenyl]-4-piperidinone were condensed with ethyl cyanoacetate or malononitrile to form ylidene derivatives, which were then subjected sequentially to (i) catalytic or
Publikováno v:
Journal of Medicinal Chemistry. 37:2167-2174
Analogues of N~-(4-amino-4-deoxypteroyl)-N~-(hemiphthaloyl)-~-ornithine (PT523) with 3',5'dichloro substitution in the p-aminobenzoyl moiety or with one less or one more CH2 group in the amino acid moiety were synthesized and tested as inhibitors of
Autor:
Henry Bader, Andre Rosowsky
Publikováno v:
ChemInform. 22
The di- through penta-γ-L-glutamates of 2-desamino-2-methylaminopterin, a new antifolate with a novel mechanism of action requiring γ-polyglutamylation for biological activity, were prepared. α-tert-Butyl γ-methyl L-glutamate was condensed with 4
Publikováno v:
ChemInform. 26
Autor:
Andre Rosowsky, Henry Bader
Publikováno v:
The Journal of Organic Chemistry. 56:3386-3391
The di- through penta-γ-L-glutamates of 2-desamino-2-methylaminopterin, a new antifolate with a novel mechanism of action requiring γ-polyglutamylation for biological activity, were prepared. α-tert-Butyl γ-methyl L-glutamate was condensed with 4