Výsledky vyhledávání - "Henry B C, Taylor"

Akademický článek

Friend or Foe? The Varied Faces of Homeostatic Synaptic Plasticity in Neurodegenerative Disease

Autor: Henry B. C. Taylor, Alexander F. Jeans

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2021)

Homeostatic synaptic plasticity (HSP) regulates synaptic strength both pre- and postsynaptically to ensure stability and efficient information transfer in neural networks. A number of neurological diseases have been associated with deficits in HSP, p

Externí odkaz: https://doaj.org/article/dc65afad0e864488b8517568800a9a05

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Akademický článek

A Novel Optical Quantal Analysis of Miniature Events Reveals Enhanced Frequency Following Amyloid β Exposure

Autor: Henry B. C. Taylor, Rudi Tong, Alexander F. Jeans, Nigel J. Emptage

Publikováno v: Frontiers in Cellular Neuroscience, Vol 14 (2020)

Non-evoked miniature release of neurotransmitters is increasingly recognized as playing an important role in neural function and is implicated in synaptic plasticity, metaplasticity, and homeostasis. Spontaneous miniature release events (minis) are u

Externí odkaz: https://doaj.org/article/b9144708b8674a3fadf23f0593816a3a

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Partial Suppression of Ca v2.1 Function Prevents Synaptic and Behavioral Impairments in Alzheimer's Disease Models

Autor: Alexander Jeans, Zahid Padamsey, Helen Collins, Arn M. J. M. van den Maagdenberg, Henry B. C. Taylor, David M. Bannerman, William Foster, Caroline Weglinski, Nigel J. Emptage, William L. Klein

Publikováno v: SSRN Electronic Journal.

Amyloid-β (Aβ)-dependent dysfunction and eventual loss of glutamatergic synapses is central to Alzheimer’s disease (AD) pathogenesis. However, the underlying mechanisms remain poorly understood, hindering the development of effective therapeutics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71acf0856c36d0f5aff69fed43d991c7
https://doi.org/10.2139/ssrn.3701260

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Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau

Autor: Henry B. C. Taylor, Nigel J. Emptage, Alexander Jeans

Publikováno v: Cell Reports

Summary In Alzheimer’s disease, soluble oligomers of the amyloid-β peptide (Aβo) trigger a cascade of events that includes abnormal hyperphosphorylation of the protein tau, which is essential for pathogenesis. However, the mechanistic link betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c68588b5fa5f50436946323dd220a63
https://doi.org/10.1016/j.celrep.2021.109638

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