Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Henry A. Havel"'
Autor:
Andrew T. Lucas, Manuel Sanchez-Felix, Rose T. Ajamie, Alberto Gabizon, William C. Zamboni, Zack A. Kornblum, Palaniappan Kulanthaivel, David M. Bender, Leah B. Herity, Andrew J. Madden, Alexander V. Kabanov, Henry A. Havel
Publikováno v:
International Journal of Pharmaceutics. 526:443-454
Studies have shown that nanoparticles (NPs) are cleared through the mononuclear phagocyte system (MPS). Pharmacokinetic studies of Doxil, DaunoXome, micellar doxorubicin (SP1049C) and small molecule (SM) doxorubicin were performed in SCID mice, Sprag
Autor:
Pamela Strode, Stephen E. Zale, Marc Wolfgang, Hagop Youssoufian, Iulian Bobe, Maggie Liu, Matthew Peterson, Gregory L. Finch, Henry A. Havel
Publikováno v:
The AAPS Journal. 18:1373-1378
Advancing nanomedicines from concept to clinic requires integration of new science with traditional pharmaceutical development. The medical and commercial success of nanomedicines is greatly facilitated when those charged with developing nanomedicine
Autor:
Henry A. Havel, Katie D. Stewart, Louis S. Matza, Sweetana Stephanie Ann, Joseph A. Johnston, Sarah E Curtis, Heather L. Gelhorn
Publikováno v:
Patient preference and adherence
Purpose Pharmaceutical formulation and treatment process attributes, such as dose frequency and route of administration, can have an impact on quality of life, treatment adherence, and disease outcomes. The aim of this literature review was to examin
Autor:
Henry A. Havel
Publikováno v:
The AAPS journal. 18(6)
While nanotechnology advancements have been applied to pharmaceutical products, the number of approved nanodrugs by global health authorities has not kept pace with research and development investments in the field. This article reviews the history o
Autor:
Mary Oates, Sau L. Lee, Tony Tong, Ganapathy Mohan, Giuseppe Randazzo, Michael P. Thien, Geoffrey K. Wu, Adam C. Fisher, Robert Ju, Richard T Lostritto, Emanuela Lacana, Bruce D. Johnson, Katherine M. Tyner, Stephen W. Hoag, Brian Hasselbalch, Grace McNally, Susan Rosencrance, Anna Schwendeman, Louis Yu, Moheb Nasr, Martin VanTrieste, Tara Gooen Bizjak, Henry A. Havel, Paul Seo, Siva Vaithiyalingam, Barbara Allen, Lawrence X. Yu, Ilgaz Akseli, Thomas F. O’Connor, Gregory E. Amidon, Ramesh Sood, Roger Nosal, Margaret Caulk, Ashley Boam, Janet Woodcock, Paula R Katz, Fionnuala Walsh, Robert Iser, Vinod P. Shah, Scott Furness, Larisa Wu, Russell Wesdyk, G. K. Raju, Joseph Famulare, Mahesh Ramanadham, Arzu Selen, Mehul Mehta, James E. Polli, David Doleski, Diane Zezza, Bernhardt L. Trout
Publikováno v:
The AAPS journal. 18(2)
The October 2015 FDA/PQRI Conference on Advancing Product Quality provided a forum for the exchange of ideas focused on drug product quality between regulatory agencies, the pharmaceutical industry, and academia. Key topics of the 2015 conference wer
Publikováno v:
Biopolymers. 50:153-161
Quasi-elastic light scattering (QELS), electrophoretic light scattering (ELS), CD spec- troscopy, and azide binding titrations were used to study the complexation at pH 6.8 between ferrihemoglobin and three polyelectrolytes that varied in charge dens
Publikováno v:
Biopolymers. 38:527-533
Autor:
Kevin A. Destrampe, Dawn Marie Rebhun, Dean K. Clodfelter, Allen H. Pekar, Sharon R. Myers, Henry A. Havel, Mark L. Brader
Publikováno v:
Pharmaceutical Research. 15:254-262
Purpose. To utilize an acylated peptide as a model system to investigate the relationships among solution peptide conformation, non-covalent self-association, subcutaneous absorption and bioavailability under pharmaceutically relevant solution formul
Autor:
David N. Brems, Steven Witt Dodd, Jerry Radziuk, Shun Li, Diane Lee Bakaysa, Allen H. Pekar, John Michael Beals, Mark L. Brader, Henry A. Havel
Publikováno v:
Protein Science. 5:2521-2531
The rate-limiting step for the absorption of insulin solutions after subcutaneous injection is considered to be the dissociation of self-associated hexamers to monomers. To accelerate this absorption process, insulin analogues have been designed that
Publikováno v:
Langmuir. 11:2486-2492
The system comprised of poly(dimethyldiallylammonium chloride) (PDMDAAC) and oppositely charged mixed micelles of Triton X-100 (TX100) and sodium dodecylsulfate (SDS) displays several states, including coacervate and various soluble complexes. The ph