Zobrazeno 1 - 10
of 437
pro vyhledávání: '"Henry A, Lester"'
Autor:
Neil L. Harrison, Geoffrey W. Abbott, Martina Gentzsch, Andrei Aleksandrov, Anna Moroni, Gerhard Thiel, Stephen Grant, Colin G. Nichols, Henry A. Lester, Andreas Hartel, Kenneth Shepard, David Cabrera Garcia, Masayuki Yazawa
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/412f76ba93c044a085d835ada304e2f3
Autor:
Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/098460172c5e405ebfd89ac4744a4398
Autor:
Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester
Publikováno v:
eLife, Vol 11 (2022)
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cell
Externí odkaz:
https://doaj.org/article/4b4e86491b454335b0724b76381431a8
Autor:
María Constanza Maldifassi, Hugo Rego Campello, Timothy Gallagher, Henry A. Lester, Dennis A. Dougherty
Publikováno v:
Molecular Pharmacology. 103:339-347
Autor:
Sudhakar R. Subramaniam, Iddo Magen, Nicholas Bove, Chunni Zhu, Vincent Lemesre, Garima Dutta, Chris Jean Elias, Henry A. Lester, Marie-Francoise Chesselet
Publikováno v:
Neurobiology of Disease, Vol 117, Iss , Pp 170-180 (2018)
In addition to dopaminergic and motor deficits, patients with Parkinson's disease (PD) suffer from non-motor symptoms, including early cognitive and social impairment, that do not respond well to dopaminergic therapy. Cholinergic deficits may contrib
Externí odkaz:
https://doaj.org/article/2c29d81a7fbc4aa49b48c0b5d29bffcf
Autor:
Kallol Bera, Aron Kamajaya, Amol V. Shivange, Anand K. Muthusamy, Aaron L. Nichols, Philip M. Borden, Stephen Grant, Janice Jeon, Elaine Lin, Ishak Bishara, Theodore M. Chin, Bruce N. Cohen, Charlene H. Kim, Elizabeth K. Unger, Lin Tian, Jonathan S. Marvin, Loren L. Looger, Henry A. Lester
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The target for the “rapid” (100-fold selectivity over other ligands tested, including R-ketamine. We targeted each of the sensors to either the plasma membrane (PM) or the endoplasmic reticulum (ER). Measurements on these biosensors expressed in
Externí odkaz:
https://doaj.org/article/4397d649b8754ebaa97c121f59eaa73b
Autor:
Joaquin I. Hurtado-Zavala, Binu Ramachandran, Saheeb Ahmed, Rashi Halder, Christiane Bolleyer, Ankit Awasthi, Markus A. Stahlberg, Robin J. Wagener, Kristin Anderson, Ryan M. Drenan, Henry A. Lester, Julie M. Miwa, Jochen F. Staiger, Andre Fischer, Camin Dean
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
The role of TRPV1 in the CNS is not fully understood. Here the authors show that TRPV1 is expressed specifically in somatostatin-positive OLM interneurons of the hippocampus, where it promotes excitatory innervation of these cells.
Externí odkaz:
https://doaj.org/article/2105af867abe4a79822bee9ec7df90cb
Autor:
Nandan Haloi, Shan Huang, Aaron N. Nichols, Eve J. Fine, Christopher B. Marotta, Dennis A. Dougherty, Erik Lindahl, Rebecca J. Howard, Stephen L. Mayo, Henry A. Lester
Publikováno v:
bioRxiv
To develop more sensitive fluorescent protein sensors for nicotine, we combined computational protein design, site-saturated, site-directed, and combinatorial mutagenesis with fluorescence assays, molecular dynamics simulations, and absorbance measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e006d2d998b11ecd045bc5d0daafcc24
https://doi.org/10.1101/2023.01.16.524298
https://doi.org/10.1101/2023.01.16.524298
Autor:
Aaron L. Nichols, Zack Blumenfeld, Laura Luebbert, Hailey J. Knox, Anand K. Muthusamy, Jonathan S. Marvin, Charlene H. Kim, Stephen N. Grant, David P. Walton, Bruce N. Cohen, Rebekkah Hammar, Loren L. Looger, Per Artursson, Dennis A. Dougherty, Henry A. Lester
Publikováno v:
Journal of Neuroscience
bioRxiv
bioRxiv
Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depressive disorder (MDD). The therapeutic mechanisms that take place before, during, or after SSRIs bind the serotonin transporter (
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Alcohol and nicotine are two of the most frequently abused drugs, with their comorbidity well described. Previous data show that chronic exposure to nicotine upregulates high-affinity nicotinic acetylcholine receptors (nAChRs) in several brain areas.
Externí odkaz:
https://doaj.org/article/9753b027be0044c8ac59844cb261cc3f