Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Henry, Weiner"'
Autor:
Theodore F. Saad, Henry Weiner
Publikováno v:
Seminars in Dialysis. 30:187-192
End-stage renal disease is frequently accompanied by cardiac comorbidity that warrants treatment with a cardiovascular implantable electronic device (permanent pacemaker or implantable cardioverter-defibrillator). In the United States, chronic hemodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb33e7a1100ad53d8dd9b426812bf6ca
https://doi.org/10.1111/sdi.12581
https://doi.org/10.1111/sdi.12581
Autor:
Vikashsingh P. Rambhujun, Talal Al-Mohamad, Muhammad Abubakar Shakir, Henry Weiner, Audrey Sernyak
Publikováno v:
Journal of the American College of Cardiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b0693ed20b867fd4f4c74a309014b6
https://doi.org/10.1016/s0735-1097(21)03361-1
https://doi.org/10.1016/s0735-1097(21)03361-1
Publikováno v:
Chemico-Biological Interactions. 202:32-40
Amongst the numerous conserved residues in the aldehyde dehydrogenase superfamily, the precise role of Thr-244 remains enigmatic. Crystal structures show that this residue lies at the interface between the coenzyme-binding and substrate-binding sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07688233242015d243df8e848f2f00f9
https://doi.org/10.1016/j.cbi.2012.12.009
https://doi.org/10.1016/j.cbi.2012.12.009
Autor:
Dinesh A. Nagegowda, Kwok Ki Ho, Michael C. Long, Debra M. Sherman, Jennifer Schnepp, Henry Weiner, David Rhodes, Natalia Dudareva, Yasuhisa Kaminaga, Christine M. Kish
Publikováno v:
The Plant Journal. 59:256-265
SUMMARYBenzoic acid (BA) is an important building block in a wide spectrum of compounds varying from primarymetabolites to secondary products. Benzoic acid biosynthesis from L -phenylalanine requires shortening of thepropyl side chain by two carbons,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bd30753993b183c86c0f3a21bf76f6
https://doi.org/10.1111/j.1365-313x.2009.03864.x
https://doi.org/10.1111/j.1365-313x.2009.03864.x
Publikováno v:
Biochemical Pharmacology. 76:690-696
Cyclophosphamides are pro-drugs whose killing agent is produced from an aldehyde that is formed by the action of a P450 oxidation step. The mustard from the aldehyde can destroy bone marrow cells as well as the tumor. Aldehyde dehydrogenase (EC 1.2.1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c052eeef9865ec5a71b81691670fe06
https://doi.org/10.1016/j.bcp.2008.06.018
https://doi.org/10.1016/j.bcp.2008.06.018
Autor:
Matthias Oelze, Ulrich Hink, Andreas Daiber, Kwok Ki Ho, Thomas Münzel, Henry Weiner, Christian F. Vahl, N Kayhan, Hanke Mollnau, Catharina Kraatz, Jordis Trischler, Philip Wenzel
Publikováno v:
Journal of the American College of Cardiology. 50(23):2226-2232
Objectives We tested the hypothesis of whether an inhibition of the nitroglycerin (GTN) bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) contributes to GTN tolerance in human blood vessels. Background The hemodynamic effects of GTN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0272f1d8de4aaa889017c85464cf818c
Autor:
Abhijit Mukhopadhyay, Henry Weiner
Publikováno v:
Advanced Drug Delivery Reviews. 59:729-738
Mitochondria is where the bulk of the cell’s ATP is produced. Mutations occur to genes coding for members of the complexes involved in energy production. Some are a result of damages to nuclear coded genes and others to mitochondrial coded genes. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001222906d08690e172c8b753af8df49
https://doi.org/10.1016/j.addr.2007.06.004
https://doi.org/10.1016/j.addr.2007.06.004
Autor:
Matthew J. Picklo, Ales Honzatko, Rongying Wang, Henry Weiner, Jiri Brichac, Xiaoning Lu, Kwok Ki Ho
Publikováno v:
Chemical Research in Toxicology. 20:887-895
trans-4-Hydroxy-2-nonenal (HNE) is a cytotoxic alpha,beta-unsaturated aldehyde implicated in the pathology of multiple diseases involving oxidative damage. Oxidation of HNE by aldehyde dehydrogenases (ALDHs) to trans-4-hydroxy-2-nonenoic acid (HNEA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eafe6d9e9a717b9216a2f47550b1c69
https://doi.org/10.1021/tx7000509
https://doi.org/10.1021/tx7000509
Autor:
Kwok Ki Ho, Swaantje Schuppan, Thomas Münzel, Philip Wenzel, Karin Schaeuble, Stefan Schildknecht, Markus Bachschmid, Matthias Oelze, Ulrich Hink, Henry Weiner, Andreas Daiber
Publikováno v:
Journal of Biological Chemistry. 282:792-799
Chronic therapy with nitroglycerin results in a rapid development of nitrate tolerance, which is associated with an increased production of reactive oxygen species. We have recently shown that mitochondria are an important source of nitroglycerin-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39b5e3edaf0f116d693980b3679e281d
https://doi.org/10.1074/jbc.m606477200
https://doi.org/10.1074/jbc.m606477200
Publikováno v:
Biochemistry. 45:9445-9453
Random mutagenesis followed by a filter-based screening assay has been used to identify a mutant of human class 1 aldehyde dehydrogenase (ALDH1) that was no longer inhibited by Mg(2+) ions but was activated in their presence. Several mutants possesse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ec46e1db13d8a8ca44241903b8cbfc
https://doi.org/10.1021/bi060718c
https://doi.org/10.1021/bi060718c