Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Henry, Verschoof"'
Autor:
Sultan Chowdhury, Christoph Martin Dehnhardt, Tao Sheng, Clint Young, Rainbow Kwan, Michael Scott Wilson, Jun Chen, Matthew Waldbrook, Dinah Misner, C. Lee Robinette, Rebecca M. Reese, Elaine Chang, Henry Verschoof, Tanja S. Zabka, Girish Bankar, Philippe Bergeron, Luis Sojo, Karen Nelkenbrecher, Daniel P. Sutherlin, Amy Kim, Ivan William Hemeon, Andrea Lindgren, Jae H. Chang, Alla Yurevna Zenova, Shaoyi Sun, Jonathan Maher, Shannon D. Shields, Jun Li, Daniel F. Ortwine, David H. Hackos, Zhiwei Xie, Thilo Focken, Charles J. Cohen, Richard T. Dean, Shannon Decker, Janette Mezeyova, Kuldip Khakh, Antonio G. DiPasquale, Chien-An Chen, Andrew D. White, Brian Safina, Jodie Pang, Qi Jia, Sophia Lin, Jean-Christophe Andrez, J. P. Johnson, Steven J. McKerrall
Publikováno v:
Journal of Medicinal Chemistry. 64:2953-2966
Nav1.7 is an extensively investigated target for pain with a strong genetic link in humans, yet in spite of this effort, it remains challenging to identify efficacious, selective, and safe inhibitors. Here, we disclose the discovery and preclinical p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8a9431d81bf8ca2eed0fbbfbb36905
https://doi.org/10.1021/acs.jmedchem.1c00049
https://doi.org/10.1021/acs.jmedchem.1c00049
Autor:
Brian S, Safina, Steven J, McKerrall, Shaoyi, Sun, Chien-An, Chen, Sultan, Chowdhury, Qi, Jia, Jun, Li, Alla Y, Zenova, Jean-Christophe, Andrez, Girish, Bankar, Philippe, Bergeron, Jae H, Chang, Elaine, Chang, Jun, Chen, Richard, Dean, Shannon M, Decker, Antonio, DiPasquale, Thilo, Focken, Ivan, Hemeon, Kuldip, Khakh, Amy, Kim, Rainbow, Kwan, Andrea, Lindgren, Sophia, Lin, Jonathan, Maher, Janette, Mezeyova, Dinah, Misner, Karen, Nelkenbrecher, Jodie, Pang, Rebecca, Reese, Shannon D, Shields, Luis, Sojo, Tao, Sheng, Henry, Verschoof, Matthew, Waldbrook, Michael S, Wilson, Zhiwei, Xie, Clint, Young, Tanja S, Zabka, David H, Hackos, Daniel F, Ortwine, Andrew D, White, J P, Johnson, C Lee, Robinette, Christoph M, Dehnhardt, Charles J, Cohen, Daniel P, Sutherlin
Publikováno v:
Journal of medicinal chemistry. 64(6)
Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d744b2a5894fa87236be1caf92c75b8b
https://pubmed.ncbi.nlm.nih.gov/33682420
https://pubmed.ncbi.nlm.nih.gov/33682420
Autor:
Steven W. Jones, Chang Liu, Daniel F. Ortwine, David H. Hackos, Maureen Beresini, Henry Verschoof, Tianbo Li, Steven J. McKerrall, Jun Chen, Daniel P. Sutherlin, Charles J. Cohen, Kuldip Khakh, Gang Lu, Tania Chernov-Rogan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Subtype-selective modulation of ion channels is often important, but extremely difficult to achieve for drug development. Using Nav1.7 as an example, we show that this challenge could be attributed to poor design in ion channel assays, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a61efe267f7dcc33ea85b5750295e6b
http://europepmc.org/articles/PMC5789920
http://europepmc.org/articles/PMC5789920
Autor:
Shaoyi Sun, Ray Chui, Ivana Rajlic, Jonathan Langille, Qi Jia, Shifeng Liu, Jianyu Sun, Wendy Young, Sultan Chowdhury, Jianmin Fu, Jing Zhong, Mikhail Chafeev, Zaihui Zhang, Sazzad Hossain, Henry Verschoof, Mark Wood, Kuldip Khakh, Tom Hsieh, Serguei Sviridov, Audrey Wang, Xing Cheng, Rainbow Kwan, Cadieux Jean-Jacques
Publikováno v:
Medicinal Chemistry Research. 22:1825-1836
The structure–activity relationship of a new series of tetracyclic spirooxindoles led to the discovery of compound 25a, a potent hNaV1.7 blocker with improved ADME properties and in vivo efficacy in the CFA-induced inflammatory pain model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::140743f6d89198f0c7f887c44e1f4632
https://doi.org/10.1007/s00044-012-0180-1
https://doi.org/10.1007/s00044-012-0180-1
Autor:
Simon N. Pimstone, James Price, Conrad Winters, Henry Verschoof, Charles Jay Cohen, Nicola Anne Price, Robin Sherrington, Clint Young, Rostam Namdari, Y P Goldberg, Michael R. Hayden, M.H. Lamers
Publikováno v:
Pain, 153, 80-5
Pain, 153, 1, pp. 80-5
Pain, 153, 1, pp. 80-5
Item does not contain fulltext Mutations in the SCN9A gene leading to deficiency of its protein product, Na(v)1.7, cause congenital indifference to pain (CIP). CIP is characterized by the absence of the ability to sense pain associated with noxious s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a348571150a7312357b621ec081131b2
https://doi.org/10.1016/j.pain.2011.09.008
https://doi.org/10.1016/j.pain.2011.09.008
Autor:
Brian Safina, Honorio Sampang, Bobby Brillantes, Christopher M. Koth, Hoangdung Ho, Shivani Ahuja, Sophia Lin, Christoph Martin Dehnhardt, Krista K. Bowman, Michael Edward Grimwood, Ping Wu, Melissa A. Starovasnik, David H. Hackos, Christine Tam, J. P. Johnson, Charles J. Cohen, Zhiwei Xie, Jian Payandeh, Yvonne Franke, Kuldip Khakh, Mary Coons, Kevin R Clark, Jun Li, Susmith Mukund, Elaine Chang, Jean-Christophe Andrez, Stephanie Shriver, Daniel F. Ortwine, Kyle Mortara, Clint Young, Alberto Estevez, Henry Verschoof, Thilo Focken, Daniel P. Sutherlin, Lunbin Deng
Publikováno v:
Science. 350
Voltage-gated sodium (Nav) channels propagate action potentials in excitable cells. Accordingly, Nav channels are therapeutic targets for many cardiovascular and neurological disorders. Selective inhibitors have been challenging to design because the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ca24c2468f257b0ad883c68b2e4c30
https://doi.org/10.1126/science.aac5464
https://doi.org/10.1126/science.aac5464
Autor:
Charles J. Cohen, Kuldip Khakh, Henry Verschoof, Steven W. Jones, David H. Hackos, Jun Chen, Steve McKerrall, Tianbo Li, Dan Sutherlin, Tania Chernov-Rogan
Publikováno v:
Biophysical Journal. 112:333a
The voltage-gated sodium channel Nav1.7 is one of the most validated pain targets, as gain-of-function mutations cause excessive pain, whereas loss-of-function mutations produce insensitivity to pain. Targeting Nav1.7 holds great promise in treating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a3019b115c4a4b3b3008751fe57f8c7
https://doi.org/10.1016/j.bpj.2016.11.1801
https://doi.org/10.1016/j.bpj.2016.11.1801
Autor:
Chernov-Rogan, Tania, Tianbo Li, Gang Lu, Henry Verschoof, Kuldip Khakh, Jones, Steven W., Beresini, Maureen H., Chang Liu, Ortwine, Daniel F., Mckerrall, Steven J., Hackos, David H., Sutherlin, Daniel, Cohen, Charles J., Jun Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 1/23/2018, Vol. 115 Issue 4, p792-801, 10p