Zobrazeno 1 - 10
of 571
pro vyhledávání: '"Henry, Rusinek"'
Autor:
Tovia Jacobs, Sean R. Jacobson, Juan Fortea, Jeffrey S. Berger, Alok Vedvyas, Karyn Marsh, Tianshe He, Eugenio Gutierrez-Jimenez, Nathanael R. Fillmore, Moses Gonzalez, Luisa Figueredo, Naomi L. Gaggi, Chelsea Reichert Plaska, Nunzio Pomara, Esther Blessing, Rebecca Betensky, Henry Rusinek, Henrik Zetterberg, Kaj Blennow, Lidia Glodzik, Thomas M. Wisniweski, Mony J. de Leon, Ricardo S. Osorio, Jaime Ramos-Cejudo, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background An elevated neutrophil–lymphocyte ratio (NLR) in blood has been associated with Alzheimer’s disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting inves
Externí odkaz:
https://doaj.org/article/64735eb95a84489b999f38452eb3aac9
Autor:
Tracy Butler, Julia Schubert, Nikolaos A. Karakatsanis, Xiuyuan Hugh Wang, Ke Xi, Yeona Kang, Kewei Chen, Liangdong Zhou, Edward K. Fung, Abigail Patchell, Abhishek Jaywant, Yi Li, Gloria Chiang, Lidia Glodzik, Henry Rusinek, Mony de Leon, Federico Turkheimer, Sudhin A. Shah
Publikováno v:
Neurotrauma Reports, Vol 5, Iss 1, Pp 359-366 (2024)
Brain fluid clearance by pathways including the recently described paravascular glymphatic system is a critical homeostatic mechanism by which metabolic products, toxins, and other wastes are removed from the brain. Brain fluid clearance may be espec
Externí odkaz:
https://doaj.org/article/416f7eb348bb4d079b21ecc32ecb50a0
Autor:
Neel H. Mehta, Xiuyuan Wang, Samantha A. Keil, Ke Xi, Liangdong Zhou, Kevin Lee, Wanbin Tan, Edward Spector, Amirhossein Goldan, James Kelly, Nicolas A. Karakatsanis, P. David Mozley, Sadek Nehmeh, J. Levi Chazen, Simon Morin, John Babich, Jana Ivanidze, Silky Pahlajani, Emily B. Tanzi, Leslie Saint-Louis, Tracy Butler, Kewei Chen, Henry Rusinek, Roxana O. Carare, Yi Li, Gloria C. Chiang, Mony J. de Leon
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Background Reduced clearance of cerebrospinal fluid (CSF) has been suggested as a pathological feature of Alzheimer’s disease (AD). With extensive documentation in non-human mammals and contradictory human neuroimaging data it remains unkn
Externí odkaz:
https://doaj.org/article/038120f6c203440699043248097157ee
Autor:
Anna M. Chen, Martin Gajdošík, Wajiha Ahmed, Sinyeob Ahn, James S. Babb, Esther M. Blessing, Allal Boutajangout, Mony J. de Leon, Ludovic Debure, Naomi Gaggi, Mia Gajdošík, Ajax George, Mobeena Ghuman, Lidia Glodzik, Patrick Harvey, Christoph Juchem, Karyn Marsh, Rosemary Peralta, Henry Rusinek, Sulaiman Sheriff, Alok Vedvyas, Thomas Wisniewski, Helena Zheng, Ricardo Osorio, Ivan I. Kirov
Publikováno v:
NeuroImage, Vol 297, Iss , Pp 120742- (2024)
ABSTRACT: Purpose: The pathological hallmarks of Alzheimer's disease (AD), amyloid, tau, and associated neurodegeneration, are present in the cortical gray matter (GM) years before symptom onset, and at significantly greater levels in carriers of the
Externí odkaz:
https://doaj.org/article/df54edeec1d44a40b0c054d4676011a6
Diffusion imaging markers of accelerated aging of the lower cingulum in subjective cognitive decline
Autor:
Ryn Flaherty, Yu Veronica Sui, Arjun V. Masurkar, Rebecca A. Betensky, Henry Rusinek, Mariana Lazar
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionAlzheimer’s Disease (AD) typically starts in the medial temporal lobe, then develops into a neurodegenerative cascade which spreads to other brain regions. People with subjective cognitive decline (SCD) are more likely to develop dement
Externí odkaz:
https://doaj.org/article/f92214ef276547619f90040d39b6d5b3
Publikováno v:
Brain Multiphysics, Vol 5, Iss , Pp 100072- (2023)
Periventricular white matter hyperintensities (WMH) are a common finding in medical images of the aging brain and are associated with white matter damage resulting from cerebral small vessel disease, white matter inflammation, and a degeneration of t
Externí odkaz:
https://doaj.org/article/eac0436364cf4af28a595f7e61254952
Autor:
Sheng Liu, Arjun V. Masurkar, Henry Rusinek, Jingyun Chen, Ben Zhang, Weicheng Zhu, Carlos Fernandez-Granda, Narges Razavian
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Early diagnosis of Alzheimer’s disease plays a pivotal role in patient care and clinical trials. In this study, we have developed a new approach based on 3D deep convolutional neural networks to accurately differentiate mild Alzheimer’s
Externí odkaz:
https://doaj.org/article/da17dc8d2aa84529befc537abb60d9db
Autor:
Tracy Butler, Lidia Glodzik, Xiuyuan Hugh Wang, Ke Xi, Yi Li, Hong Pan, Liangdong Zhou, Gloria Chia-Yi Chiang, Simon Morim, Nimmi Wickramasuriya, Emily Tanzi, Thomas Maloney, Patrick Harvey, Xiangling Mao, Qolamreza Ray Razlighi, Henry Rusinek, Dikoma C. Shungu, Mony de Leon, Craig S. Atwood, P. David Mozley
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-6 (2022)
Abstract In rodents, hypothalamic inflammation plays a critical role in aging and age-related diseases. Hypothalamic inflammation has not previously been assessed in vivo in humans. We used Positron Emission Tomography (PET) with a radiotracer sensit
Externí odkaz:
https://doaj.org/article/96dc370dcd8d46b4a6ea74eee150164a
Autor:
Yi Li, Henry Rusinek, Tracy Butler, Lidia Glodzik, Elizabeth Pirraglia, John Babich, P. David Mozley, Sadek Nehmeh, Silky Pahlajani, Xiuyuan Wang, Emily B. Tanzi, Liangdong Zhou, Sara Strauss, Roxana O. Carare, Neil Theise, Nobuyuki Okamura, Mony J. de Leon
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-9 (2022)
Abstract Background In sporadic Alzheimer’s disease (AD), brain amyloid-beta (Aβ) deposition is believed to be a consequence of impaired Aβ clearance, but this relationship is not well established in living humans. CSF clearance, a major feature
Externí odkaz:
https://doaj.org/article/4885e6645f9045a8868a02d6ab9e11d9
Autor:
Sheng Liu, Arjun V. Masurkar, Henry Rusinek, Jingyun Chen, Ben Zhang, Weicheng Zhu, Carlos Fernandez-Granda, Narges Razavian
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/893f04f2533b40ba9ff5447a452d64fb