Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Henry, Fechner"'
Autor:
Leslie Elsner, Lisanne Heimann, Anja Geisler, Babette Dieringer, Klaus-Peter Knoch, Luisa Hinze, Karin Klingel, Michel Solimena, Jens Kurreck, Henry Fechner
Publikováno v:
Biological Procedures Online, Vol 26, Iss 1, Pp 1-16 (2024)
Abstract Background The efficacy of oncolytic viruses (OV) in cancer treatment depends on their ability to successfully infect and destroy tumor cells. However, patients’ tumors vary, and in the case of individual insensitivity to an OV, therapeuti
Externí odkaz:
https://doaj.org/article/12073503249b4b00bb4d7853be5b2933
Autor:
Anja Geisler, Babette Dieringer, Leslie Elsner, Karin Klingel, Robert Klopfleisch, Hans-Peter Vornlocher, Jens Kurreck, Henry Fechner
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 923-936 (2023)
RNA interference has demonstrated its potential as an antiviral therapy for treatment of human adenovirus (hAd) infections. The only existing viral vector-based system for delivery of anti-adenoviral artificial microRNAs available for in vivo use, ho
Externí odkaz:
https://doaj.org/article/8f857671448d4f67b3c18507d9e19145
Autor:
Kathleen Pappritz, Jie Lin, Muhammad El‐Shafeey, Henry Fechner, Uwe Kühl, Alessio Alogna, Frank Spillmann, Ahmed Elsanhoury, Rainer Schulz, Carsten Tschöpe, Sophie Van Linthout
Publikováno v:
ESC Heart Failure, Vol 9, Iss 2, Pp 925-941 (2022)
Abstract Aim The acute phase of a coxsackievirus 3 (CVB3)‐induced myocarditis involves direct toxic cardiac effects and the systemic activation of the immune system, including the cardiosplenic axis. Consequently, the nucleotide‐binding oligomeri
Externí odkaz:
https://doaj.org/article/a2758d127c774136b0ea4616cf588917
Autor:
Izabela Kraszewska, Mateusz Tomczyk, Kalina Andrysiak, Monika Biniecka, Anja Geisler, Henry Fechner, Michał Zembala, Jacek Stępniewski, Józef Dulak, Agnieszka Jaźwa-Kusior
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 1190-1201 (2020)
Systemically delivered adeno-associated viral vector serotype 9 (AAV9) effectively transduces murine heart, but provides transgene expression also in liver and skeletal muscles. Improvement of the selectivity of transgene expression can be achieved t
Externí odkaz:
https://doaj.org/article/e31943af4dc24b31b50d9af45a05ad0e
Autor:
Ahmet Hazini, Babette Dieringer, Karin Klingel, Markian Pryshliak, Anja Geisler, Dennis Kobelt, Ole Daberkow, Jens Kurreck, Sophie van Linthout, Henry Fechner
Publikováno v:
Viruses, Vol 13, Iss 10, p 1918 (2021)
The coxsackievirus B3 strain PD-0 has been proposed as a new oncolytic virus for the treatment of colorectal carcinoma. Here, we generated a cDNA clone of PD-0 and analyzed the virus PD-H, newly generated from this cDNA, in xenografted and syngenic m
Externí odkaz:
https://doaj.org/article/8d54fbe139e848008b4fb87dcb4632ec
Autor:
Katrin Schaar, Anja Geisler, Milena Kraus, Sandra Pinkert, Markian Pryshliak, Jacqueline F. Spencer, Ann E. Tollefson, Baoling Ying, Jens Kurreck, William S. Wold, Robert Klopfleisch, Karoly Toth, Henry Fechner
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 300-316 (2017)
Infections of immunocompromised patients with human adenoviruses (hAd) can develop into life-threatening conditions, whereas drugs with anti-adenoviral efficiency are not clinically approved and have limited efficacy. Small double-stranded RNAs that
Externí odkaz:
https://doaj.org/article/e97e24c9cc81475f96113129d27f1781
Autor:
Dirk M. Nettelbeck, Mathias F. Leber, Jennifer Altomonte, Assia Angelova, Julia Beil, Susanne Berchtold, Maike Delic, Jürgen Eberle, Anja Ehrhardt, Christine E. Engeland, Henry Fechner, Karsten Geletneky, Katrin Goepfert, Per Sonne Holm, Stefan Kochanek, Florian Kreppel, Lea Krutzke, Florian Kühnel, Karl Sebastian Lang, Antonio Marchini, Markus Moehler, Michael D. Mühlebach, Ulrike Naumann, Roman Nawroth, Jürg Nüesch, Jean Rommelaere, Ulrich M. Lauer, Guy Ungerechts
Publikováno v:
Viruses, Vol 13, Iss 8, p 1420 (2021)
Virotherapy research involves the development, exploration, and application of oncolytic viruses that combine direct killing of cancer cells by viral infection, replication, and spread (oncolysis) with indirect killing by induction of anti-tumor immu
Externí odkaz:
https://doaj.org/article/2afbc836e8844aa9a40984a8fca1af73
Publikováno v:
Viruses, Vol 13, Iss 5, p 718 (2021)
Oncolytic virotherapy represents one of the most advanced strategies to treat otherwise untreatable types of cancer. Despite encouraging developments in recent years, the limited fraction of patients responding to therapy has demonstrated the need to
Externí odkaz:
https://doaj.org/article/a424ce00607d422897220f4546619bef
Autor:
Franziska Jönsson, Jürgen Eberle, Sina Zarif, Florian Kreppel, Ahmet Hazini, Babette Dieringer, Jens Kurreck, Beatrice Tolksdorf, Henry Fechner
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Abstract Arming of oncolytic viruses with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown as a viable approach to increase the antitumor efficacy in melanoma. However, melanoma cells may be partially or completely resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958ad7aaf4ad855e2922302f0f42b22e
https://doi.org/10.1007/s00109-021-02081-3
https://doi.org/10.1007/s00109-021-02081-3
Autor:
Beatrice Tolksdorf, Henry Fechner, Jens Kurreck, Kathleen Pappritz, Michele Solimena, Antje Beling, Lisanne Heimann, Klaus-Peter Knoch, Babette Dieringer, Markian Pryshliak, Muhammad El-Shafeey, Ahmet Hazini, Karin Klingel
Publikováno v:
Human Gene Therapy. 32:216-230
Coxsackievirus B3 (CVB3) has strong oncolytic activity in colorectal carcinoma but it also infects the pancreas and the heart. To improve the safety of the virus, here we investigated whether pancreas and cardiac toxicity can be prevented by insertio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda4079d3bcbcf1fc72bb0dcc9ff7c0a
https://doi.org/10.1089/hum.2020.228
https://doi.org/10.1089/hum.2020.228