Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Henrike Veith"'
Autor:
Hugh P. Morgan, Paul A.M. Michels, Matthew W. Nowicki, Elizabeth A. Blackburn, Malcolm D. Walkinshaw, Douglas S. Auld, Min Shen, Martin A. Wear, Linda A. Fothergill-Gilmore, Iain W. McNae, Henrike Veith, Martin J. Walsh, Matthew B. Boxer
Publikováno v:
Morgan, H P, Walsh, M J, Blackburn, E A, Wear, M A, Boxer, M B, Shen, M, Veith, H, McNae, I W, Nowicki, M W, Michels, P A M, Auld, D S, Fothergill-Gilmore, L A & Walkinshaw, M D 2012, ' A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase ', Biochemical Journal, vol. 448, no. 1, pp. 67-72 . https://doi.org/10.1042/BJ20121014
PYK (pyruvate kinase) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems biology context has been hampered by the lack of specific high-affinity small-molecule inhi
Autor:
Hongmao Sun, Menghang Xia, Ruili Huang, Raymond R. Tice, Christopher P. Austin, Henrike Veith
Publikováno v:
Molecular Informatics. 31:783-792
The human cytochrome P450 (CYP) enzyme family is involved in the biotransformation of many xenobiotics. As part of the U.S. Tox21 Phase I effort, we profiled the CYP activity of approximately three thousand compounds, primarily those of environmental
Autor:
Lewis C. Cantley, William Leister, Kyle R. Brimacombe, Matthew G. Vander Heiden, Henrike Veith, Martin J. Walsh, Matthew B. Boxer, Min Shen, Douglas S. Auld, James M. Bougie, Thomas Daniel, Craig J. Thomas, William J. Israelsen
Publikováno v:
PMC
Compared to normal differentiated cells, cancer cells have altered metabolic regulation to support biosynthesis and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this anabolic metabolism. While the M1 isoform i
Publikováno v:
Journal of Chemical Information and Modeling. 51:2474-2481
The human cytochrome P450 (CYP450) isozymes are the most important enzymes in the body to metabolize many endogenous and exogenous substances including environmental toxins and therapeutic drugs. Any unnecessary interactions between a small molecule
Autor:
Tim James, Henrike Veith, Ruili Huang, David Lloyd, Douglas S. Auld, Noel Southall, James Inglese, Darren Fayne, Christopher P. Austin, Min Shen, Natalia Artemenko
Publikováno v:
Nature biotechnology
The cytochrome P450 (CYP) gene family catalyzes drug metabolism and bioactivation and is therefore relevant to drug development. We determined potency values for 17,143 compounds against five recombinant CYP isozymes (1A2, 2C9, 2C19, 2D6 and 3A4) usi
Autor:
Christopher M. Tegley, Philip Tagari, José M. Morachis, Jeffery K. Lewis, Violeta Yu, Robert J.M. Kurzeja, Jennifer Dao, Henrike Veith
Publikováno v:
Analytical Biochemistry. 384:213-223
The human hypoxia-inducible factor prolyl hydroxylases 1, 2, and 3 (HIF-PHD1, -2, and -3) are thought to act as proximal sensors of cellular hypoxia by virtue of their mechanism-based dependence on molecular oxygen. These 2-oxoglutarate (2-OG) and no
Autor:
Randall W. Hungate, Jennifer Dao, Christopher M. Tegley, Sean Yoder, Catherine H. Chang, Tanya Peterkin, Roland Burli, Henrike Veith, Jennifer R. Allen, Philip Tagari, Norma Rogers, Kaustav Biswas, Vellarkad N. Viswanadhan, Michael J. Frohn, Gloria Biddlecome
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3925-3928
Inhibition of the PHD2 enzyme has been associated with increased red blood cell levels. From a screening hit, a series of novel hydroxyl-thiazoles were developed as potent PHD2 inhibitors.
Autor:
Roland Meier-Bornheim, Maren Hansen, Benedikt Hartwig, Henrike Veith, Norbert Schaschke, Brit K. Wolters, Heiko Büth, Werner Machleidt, Christian P. Sommerhoff, Klaudia Brix, Petra Boukamp, Norbert E. Fusenig
Publikováno v:
European Journal of Cell Biology. 83:781-795
Cathepsin B, a lysosomal cysteine proteinase, was detected within vesicles of cellular protrusions forming cell-cell contact sites between keratinocytes of the stratum spinosum of human skin. This observation suggested the possibility that secretion
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 987
The cytochrome P450 (CYP) family contains 57 enzymes in humans. The activity of CYPs against xenobiotics is a primary consideration in drug optimization efforts. Here we describe a series of bioluminescent assays that enable the rapid profiling of CY
Publikováno v:
Methods in Molecular Biology ISBN: 9781627033206
The cytochrome P450 (CYP) family contains 57 enzymes in humans. The activity of CYPs against xenobiotics is a primary consideration in drug optimization efforts. Here we describe a series of bioluminescent assays that enable the rapid pro filing of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02abf827f3535248dc2ccadac8bc4e4b
https://doi.org/10.1007/978-1-62703-321-3_1
https://doi.org/10.1007/978-1-62703-321-3_1