Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Henrike Heise"'
Autor:
Kevin Herr, Mark V. Höfler, Henrike Heise, Fabien Aussenac, Felix Kornemann, David Rosenberger, Martin Brodrecht, Marcos de Oliveira, Jr., Gerd Buntkowsky, Torsten Gutmann
Publikováno v:
Journal of Magnetic Resonance Open, Vol 20, Iss , Pp 100152- (2024)
A versatile strategy for synthesizing tailored peptide based biradicals is presented. By labeling the protected amino acid hydroxyproline with PROXYL via the OH functionality and using this building block in solid phase peptide synthesis (SPPS), the
Externí odkaz:
https://doaj.org/article/ef63b8ac59af471d9f6450e2c80b29fd
Autor:
Luis Gardon, Nina Becker, Nick Rähse, Christoph Hölbling, Athina Apostolidis, Celina M. Schulz, Kevin Bochinsky, Lothar Gremer, Henrike Heise, Nils-Alexander Lakomek
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Misfolding of amyloidogenic proteins is a molecular hallmark of neurodegenerative diseases in humans. A detailed understanding of the underlying molecular mechanisms is mandatory for developing innovative therapeutic approaches. The bov
Externí odkaz:
https://doaj.org/article/403089fa95424092ace45d228a2cd753
Autor:
Abhishek Cukkemane, Nina Becker, Mara Zielinski, Benedikt Frieg, Nils-Alexander Lakomek, Henrike Heise, Gunnar F. Schröder, Dieter Willbold, Oliver H. Weiergräber
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Chronic mental illnesses (CMIs) pose a significant challenge to global health due to their complex and poorly understood etiologies and hence, absence of causal therapies. Research of the past two decades has revealed dysfunction of the disr
Externí odkaz:
https://doaj.org/article/0c11b45bb5c841caa492b0d561904b9f
Autor:
Kevin Herr, Max Fleckenstein, Martin Brodrecht, Mark V. Höfler, Henrike Heise, Fabien Aussenac, Torsten Gutmann, Michael Reggelin, Gerd Buntkowsky
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract A novel specific spin-labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain rattlesnakes. By specifically labeling the disulfide br
Externí odkaz:
https://doaj.org/article/3e3cc9a70aab41148a91c6390f29b657
Autor:
Thibault Viennet, Michael M. Wördehoff, Boran Uluca, Chetan Poojari, Hamed Shaykhalishahi, Dieter Willbold, Birgit Strodel, Henrike Heise, Alexander K. Buell, Wolfgang Hoyer, Manuel Etzkorn
Publikováno v:
Communications Biology, Vol 1, Iss 1, Pp 1-12 (2018)
Thibault Viennet and colleagues gain structural insight into amyloid fibril formation from their innovative use of lipid bilayer nanodiscs. This study connects α-Synuclein membrane binding modes to its aggregation properties, furthering our understa
Externí odkaz:
https://doaj.org/article/f2c2878849244bba98d09dfe5a7f89fb
Autor:
Hasier Eraña, Jorge M Charco, Michele A Di Bari, Carlos M Díaz-Domínguez, Rafael López-Moreno, Enric Vidal, Ezequiel González-Miranda, Miguel A Pérez-Castro, Sandra García-Martínez, Susana Bravo, Natalia Fernández-Borges, Mariví Geijo, Claudia D'Agostino, Joseba Garrido, Jifeng Bian, Anna König, Boran Uluca-Yazgi, Raimon Sabate, Vadim Khaychuk, Ilaria Vanni, Glenn C Telling, Henrike Heise, Romolo Nonno, Jesús R Requena, Joaquín Castilla
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008117 (2019)
The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long hindered due to certain particularities of thes
Externí odkaz:
https://doaj.org/article/215467d1d4f44efeb809d884605f8666
Autor:
Lorenz Rösler, Mark V. Höfler, Hergen Breitzke, Till Wissel, Kevin Herr, Henrike Heise, Torsten Gutmann, Gerd Buntkowsky
Publikováno v:
Cellulose 29(11), 6283-6299 (2022). doi:10.1007/s10570-022-04654-y
A novel, efficient approach for the functionalization of microcrystalline cellulose (MCC) is presented. The as-obtained material allows the immobilization of chiral dirhodium catalysts preserving their enantioselectivity in asymmetric cyclopropanatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36288969342a5541d4b0043614fb07d1
https://doi.org/10.1007/s10570-022-04654-y
https://doi.org/10.1007/s10570-022-04654-y
Autor:
Kevin Herr, Fabien Aussenac, Mark V. Höfler, Henrike Heise, Gerd Buntkowsky, Max Fleckenstein, Martin Brodrecht, Michael Reggelin, Torsten Gutmann
Publikováno v:
Scientific reports 11(1), 13714 (2021). doi:10.1038/s41598-021-92975-6
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
A novel specific spin-labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain rattlesnakes. By specifically labeling the disulfide bridge this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868988c0303addf7de7db18326b72558
http://tuprints.ulb.tu-darmstadt.de/24212/
http://tuprints.ulb.tu-darmstadt.de/24212/
Autor:
Nina Becker, Benedikt Frieg, Lothar Gremer, Tatsiana Kupreichyk, Luis Gardon, Patrick Freiburg, Philipp Neudecker, Dieter Willbold, Holger Gohlke, Henrike Heise
Publikováno v:
Journal of the American Chemical Society 145(4), 2161–2169 (2023). doi:10.1021/jacs.2c09231
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b49e96e041fa55ebae4df94a40e7bd
https://hdl.handle.net/2128/33849
https://hdl.handle.net/2128/33849
Autor:
Franziska Weirich, Lothar Gremer, Ewa A Mirecka, Stephanie Schiefer, Wolfgang Hoyer, Henrike Heise
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161243 (2016)
Amyloid deposits formed from islet amyloid polypeptide (IAPP) are a hallmark of type 2 diabetes mellitus and are known to be cytotoxic to pancreatic β-cells. The molecular structure of the fibrillar form of IAPP is subject of intense research, and t
Externí odkaz:
https://doaj.org/article/d8820075ae804732b9a07041b105c220