Monitoring of xenograft tumor growth and response to chemotherapy by non-invasive in vivo multispectral fluorescence imaging.

Autor: Henrike Caysa, Stefan Hoffmann, Jana Luetzkendorf, Lutz Peter Mueller, Susanne Unverzagt, Karsten Mäder, Thomas Mueller

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47927 (2012)

A continuous monitoring of the whole tumor burden of individuals in orthotopic tumor models is a desirable aim and requires non-invasive imaging methods. Here we investigated whether quantification of a xenograft tumor intrinsic fluorescence signal c

Externí odkaz: https://doaj.org/article/51e40a4d8adb4cc992e7638ac78a1cb1

Combretastatin A-4 derived imidazoles show cytotoxic, antivascular, and antimetastatic effects based on cytoskeletal reorganisation

Autor: Rainer Schobert, Thomas Mueller, Henrike Caysa, Bernhard Biersack, Katharina Mahal

Publikováno v: Investigational New Drugs. 33:541-554

Introduction Combretastatin A-4 (CA-4) is a natural cis-stilbene which interferes with the cellular tubulin dynamics and which selectively destroys tumour blood vessels. Its pharmacological shortcomings such as insufficient chemical stability, water

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f048807e19096dd3fd8893a0d639b154
https://doi.org/10.1007/s10637-015-0215-9

Carbohydrate plasma expanders for passive tumor targeting: In vitro and in vivo studies

Autor: Karsten Mäder, Patrick Kreideweiß, Henrike Caysa, Stefan Hoffmann, Anja Leimert, Judith Kuntsche, Thomas Mueller

Publikováno v: Hoffmann, S, Caysa, H, Kuntsche, J, Kreideweiss, P, Leimert, A, Müller, T & Mäder, K 2013, ' Carbohydrate plasma expanders for passive tumor targeting : In vitro and in vivo studies ', Carbohydrate Polymers, vol. 95, pp. 404-413 . https://doi.org/10.1016/j.carbpol.2013.03.033

The objective of this study was to investigate the suitability of carbohydrate plasma volume expanders asa novel polymer platform for tumor targeting. Many synthetic polymers have already been synthesized fortargeted tumor therapy, but potential adva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c5699afb1ebee86beec29ba3c5cff9
https://doi.org/10.1016/j.carbpol.2013.03.033

A redshifted codon-optimized firefly luciferase is a sensitive reporter for bioluminescence imaging

Autor: Henrike Caysa, Martin Messerle, Roland Jacob, Bruce R. Branchini, Nadine Müther, Ariane Söling

Publikováno v: Photochemical & Photobiological Sciences. 8:52-56

Bioluminescence imaging has evolved as a powerful tool for monitoring biological processes in vivo. As transmission efficiency of light through tissue increases greatly for wavelengths above 600 nm we examined whether a redshifted codon-optimized fir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4b9db075266fecd67a4baaea4cc7b4
https://doi.org/10.1039/b814566k

Multipotent mesenchymal stromal cells promote tumor growth in distinct colorectal cancer cells by a β1-integrin-dependent mechanism

Autor: Miriam, Widder, Jana, Lützkendorf, Henrike, Caysa, Susanne, Unverzagt, Claudia, Wickenhauser, Ralf A, Benndorf, Hans-Joachim, Schmoll, Carsten, Müller-Tidow, Thomas, Müller, Lutz P, Müller

Publikováno v: International journal of cancer. 138(4)

Tumor-stroma interactions play an essential role in the biology of colorectal carcinoma (CRC). Multipotent mesenchymal stromal cells (MSC) may represent a pivotal part of the stroma in CRC, but little is known about the specific interaction of MSC wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eddabe21ef6c7118a69e4234af9df850
https://pubmed.ncbi.nlm.nih.gov/26356035