Can the isonitrile biosynthesis enzyme ScoE assist with the biosynthesis of isonitrile groups in drug molecules? A computational study

Autor: Thirakorn Mokkawes, Sam De Visser, Henrik Wong

Publikováno v: Wong, H, Mokkawes, T & De Visser, S 2022, ' Can the isonitrile biosynthesis enzyme ScoE assist with the biosynthesis of isonitrile groups in drug molecules? A computational study ', Physical Chemistry Chemical Physics . https://doi.org/10.1039/D2CP03409C

Many drug molecules contain isonitrile substituents; however, synthesizing these compounds remains challenging in organic chemistry. The isonitrile synthesizing enzyme ScoE utilizes a substrate with the γ-Gly substituent, and using two molecules of

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http://pubs.rsc.org/en/Content/ArticleLanding/2022/CP/D2CP03409C