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A call for action: Improve reporting of research studies to increase the scientific basis for regulatory decision-making

Publikováno v: Ågerstrand, M, Christiansen, S, Hanberg, A, Rudén, C, Andersson, L, Andersen, S, Appelgren, H, Bjørge, C, Clausen, I H, Eide, D M, Hartmann, N B, Husøy, T, Halldórsson, H P, van der Hagen, M, Ingre-Khans, E, Lillicrap, A D, Beltoft, V M, Mörk, A-K, Murtomaa-Hautala, M, Nielsen, E E, Ólafsdóttir, K, Palomäki, J, Papponen, H, Reiler, E M, Stockmann-Juvala, H, Suutari, T, Tyle, H & Beronius, A 2018, ' A call for action: Improve reporting of research studies to increase the scientific basis for regulatory decision-making ', Journal of Applied Toxicology, vol. 38, no. 5, pp. 783-785 . https://doi.org/10.1002/jat.3578
Journal of Applied Toxicology

Publisher's version (útgefin grein)
This is a call for action to scientific journals to introduce reporting requirements for toxicity and ecotoxicity studies. Such reporting requirements will support the use of peer‐reviewed research studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f8af8a7ef4efcdbba673b635c0120b4f
https://hdl.handle.net/20.500.11815/1003

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Advisory self-classifications for 54,135 substances based on (Q)SAR predictions from the Danish (Q)SAR database, VEGA QSAR and the OECD QSAR Toolbox

Autor: Nikolai Georgiev Nikolov, Henrik Tyle, Magnus Løfstedt, Eva Bay Wedebye

Publikováno v: Nikolov, N G, Tyle, H, Løfstedt, M & Wedebye, E B 2018, ' Advisory self-classifications for 54,135 substances based on (Q)SAR predictions from the Danish (Q)SAR database, VEGA QSAR and the OECD QSAR Toolbox ' QSAR2018, Bled, Slovenia, 11/06/2018-15/06/2018, .
Technical University of Denmark Orbit

Lack of experimental data on toxicological properties make it difficult for companies to self-classify the chemical substances they import or produce. To address this issue, 80,085 pre-registered and/or registered REACH substances from the Danish (Q)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f0e2e20ddebfef3b82202337d2f7410f
http://orbit.dtu.dk/ws/files/162539742/Wedebye_QSAR_2018_abstract_updated_use_this.pdf

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Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH)

Autor: Marta, Sobanska, Stefan, Scholz, Anna-Maija, Nyman, Romanas, Cesnaitis, Simon, Gutierrez Alonso, Nils, Klüver, Ralph, Kühne, Henrik, Tyle, Joop, de Knecht, Zhichao, Dang, Ivar, Lundbergh, Claudio, Carlon, Wim, De Coen

Publikováno v: Environmental toxicology and chemistry. 37(3)

In 2013 the Organisation for Economic Co-operation and Development (OECD) test guideline (236) for fish embryo acute toxicity (FET) was adopted. It determines the acute toxicity of chemicals to embryonic fish. Previous studies show a good correlation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5f73196b7909d1fd6e1bd26032098c4
https://pubmed.ncbi.nlm.nih.gov/29226368

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European Union System for the Evaluation of Substances (EUSES). Principles and structure

Autor: D.T. Jager, P.T.J. van der Zandt, H. Niessen, Bernd M. Bussian, J. Devillers, Björn Hansen, S. Robertson, Theo Vermeire, Henrik Tyle, I. Lundberg, K. den Haan

Publikováno v: Chemosphere. 34:1823-1836

In the European Union, Directive 92/32/EC and EC Council Regulation (EC) 793/93 require the risk assessment of new and existing substances, respectively. Principles for this risk assessment have been laid down, supported by a detailed package of Tech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4213a0186ed5adfd127525dd07fa2d
https://doi.org/10.1016/s0045-6535(97)00017-9

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Aquatic hazard and risk assessment of two selected substances produced in high volumes in the Slovak Republic

Autor: Iveta Drastichová, Finn Pedersen, Martin Murín, Axel Damborg, Juraj Gavora, Jens Tørsløv, Elena Dušková, Henrik Tyle, Torben Madsen

Publikováno v: Chemosphere. 34:179-190

In the EU, the work on the development of a standardised guidance for risk assessment of chemical substances has been going on for the latest few years. The principles in this guidance were used for assessing the aquatic risk of two substances: capro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::198062f41715ea2ab9fbf0c4ec29d352
https://doi.org/10.1016/s0045-6535(96)00357-8

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New developments of the UNIFAC model for environmental application

Autor: Fei Chen, Henrik Tyle, John Holten-Andersen

Publikováno v: Chen, F, Holten-Andersen, J & Tyle, H 1993, ' New Developments of the Unifac Model for Environmental Application ' Chemosphere, vol. 26, no. 7, pp. 1325-1354 .

The latest UNIFAC group-interaction parameters are used in this investigation to evaluate the applicability of the UNIFAC model for predicting environmentally important physico-chemical properties, among others 1-octanol/water partition coefficients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667aa7665cf3868b13d58a69223cdefe
https://doi.org/10.1016/0045-6535(93)90185-8

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Mixed-function oxygenase in juvenile rainbow trout exposed to hexachlorobenzene or 3,3',4,4'-tetrachlorobiphenyl

Autor: Mark Egsmose, Henrik Tyle, Niels Harrit

Publikováno v: Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 100(1-2)

1. 1. 3,3',4,4'-tetrachlorobiphenyl (PCB 77), but not hexachlorobenzene, induced liver micro-somal cytochrome P-450 (Cyt P-450), ethoxycoumarin- O -deethylase (ECOD) and ethoxyresorufin- O -deethylase (EROD) in rainbow trout. Maximum induction was ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b547c2c3d8a0cfbf74289dcc4359d6
https://pubmed.ncbi.nlm.nih.gov/1677847

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