Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Henrik Sperber"'
Autor:
Chan-Jung Chang, Andriana G. Kotini, Malgorzata Olszewska, Maria Georgomanoli, Julie Teruya-Feldstein, Henrik Sperber, Roberto Sanchez, Robert DeVita, Timothy J. Martins, Omar Abdel-Wahab, Robert K. Bradley, Eirini P. Papapetrou
Publikováno v:
Stem Cell Reports, Vol 10, Iss 5, Pp 1610-1624 (2018)
Summary: Connecting specific cancer genotypes with phenotypes and drug responses constitutes the central premise of precision oncology but is hindered by the genetic complexity and heterogeneity of primary cancer cells. Here, we use patient-derived i
Externí odkaz:
https://doaj.org/article/abed14ae57fa41e0af931090a4cb672c
Autor:
Diem-Hang Nguyen-Tran, Nitai C. Hait, Henrik Sperber, Junlin Qi, Karin Fischer, Nick Ieronimakis, Mario Pantoja, Aislinn Hays, Jeremy Allegood, Morayma Reyes, Sarah Spiegel, Hannele Ruohola-Baker
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 1, Pp 41-54 (2014)
Duchenne muscular dystrophy (DMD) is a lethal muscle-wasting disease. Studies in Drosophila showed that genetic increase of the levels of the bioactive sphingolipid sphingosine-1-phosphate (S1P) or delivery of 2-acetyl-5-tetrahydroxybutyl imidazole (
Externí odkaz:
https://doaj.org/article/8882fdb5b28248409e6f922a2a11cbc5
Autor:
Robert K. Bradley, Eirini P. Papapetrou, Roberto Sanchez, Robert J. DeVita, Julie Teruya-Feldstein, Timothy J. Martins, Maria Georgomanoli, Andriana G. Kotini, Henrik Sperber, Chan Jung Chang, Malgorzata Olszewska, Omar Abdel-Wahab
Publikováno v:
Stem Cell Reports, Vol 10, Iss 5, Pp 1610-1624 (2018)
Stem Cell Reports
Stem Cell Reports
Summary Connecting specific cancer genotypes with phenotypes and drug responses constitutes the central premise of precision oncology but is hindered by the genetic complexity and heterogeneity of primary cancer cells. Here, we use patient-derived in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8e9f745824bb59e983447b11b44246
https://doi.org/10.1016/j.stemcr.2018.03.020
https://doi.org/10.1016/j.stemcr.2018.03.020
Autor:
Hannele Ruohola-Baker, Henrik Sperber, Zsuzsa Agoston, Randall T. Moon, Amy Ferreccio, Yalan Xing, Julie Mathieu, Wenyu Zhou, Kavitha T. Kuppusamy
Publikováno v:
Cell Stem Cell. 14:592-605
SummaryPluripotent stem cells have distinct metabolic requirements, and reprogramming cells to pluripotency requires a shift from oxidative to glycolytic metabolism. Here, we show that this shift occurs early during reprogramming of human cells and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a640c91e334e65dd168bed01cecb72
https://doi.org/10.1016/j.stem.2014.02.012
https://doi.org/10.1016/j.stem.2014.02.012
Publikováno v:
Current Molecular Medicine. 13:757-764
There are currently 1527 known microRNAs (miRNAs) in human, each of which may regulate hundreds or thousands of target genes. miRNA expression levels vary between cell types; for example, miR- 302 and miR-290 families are highly enriched in embryonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116f2c7acacd6a7f9fa1085bbe303d4e
https://doi.org/10.2174/1566524011313050007
https://doi.org/10.2174/1566524011313050007
Autor:
Andriana G. Kotini, Shailee Vora, Aleksandra Wroblewska, Malgorzata Olszewska, Henrik Sperber, Eirini P. Papapetrou, Brian D. Brown
Publikováno v:
Blood. 132:3083-3083
A major recent discovery from large-scale sequencing studies was that over half of Myelodysplastic Syndromes (MDS) patients harbor mutations in splicing factor (SF) genes. SF mutations are the most common class of mutations in MDS and occur early in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efd4beff862dd65aa870ac9850c3363e
https://doi.org/10.1182/blood-2018-99-111857
https://doi.org/10.1182/blood-2018-99-111857
Autor:
Daciana Margineantu, Yuliang Wang, C. Anthony Blau, Daniel Raftery, Arikketh Devi, Hannele Ruohola-Baker, Jason H. Bielas, Lilyana Margaretha, Megan R. Showalter, Adam A. Margolin, Jennifer Hesson, Stephanie L. Battle, Julie Mathieu, Nolan G. Ericson, Cristina Valensisi, Damien Detraux, Zhuojin Xu, David M. Hockenbery, Oliver Fiehn, R. David Hawkins, Randall T. Moon, Karin A. Fischer, Haiwei Gu, Aaron M. Robitaille, Carol B. Ware, Henrik Sperber, Amy Ferreccio
Publikováno v:
Nature cell biology, vol 17, iss 12
For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types. Recently, it has been recognized that embryonic stem cells derived from both mice and human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be72fa2822e5e021256400c97e2208e
https://pubmed.ncbi.nlm.nih.gov/26612574
https://pubmed.ncbi.nlm.nih.gov/26612574
Autor:
Hannele Ruohola-Baker, Lil Pabon, Charles E. Murry, Nathan J. Sniadecki, Karin A. Fischer, Walter L. Ruzzo, Wei-Zhong Zhu, Anup Madan, Xiulan Yang, Marita L. Rodriguez, Kavitha T. Kuppusamy, Nathaniel L. Tulloch, Michael A. Laflamme, Henrik Sperber, Daniel C. Jones
Publikováno v:
Proceedings of the National Academy of Sciences. 112
In metazoans, transition from fetal to adult heart is accompanied by a switch in energy metabolism-glycolysis to fatty acid oxidation. The molecular factors regulating this metabolic switch remain largely unexplored. We first demonstrate that the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aec77136ba4896cf69b026066ff0a41
https://doi.org/10.1073/pnas.1424042112
https://doi.org/10.1073/pnas.1424042112
Autor:
Savannah Cook, Hannele Ruohola-Baker, Erica C. Jonlin, R. David Hawkins, Lilyana Margaretha, Paul J. Tesar, Vincenzo Cirulli, C. Anthony Blau, Jeffrey Okada, Christopher Cavanaugh, Wenyu Zhou, Michael Choi, Jennifer Hesson, Carol B. Ware, Angelique M. Nelson, Henrik Sperber, Antonio J. Jimenez-Caliani, Xinxian Deng, Brigham H. Mecham, Piper M. Treuting
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(12)
The naive pluripotent state has been shown in mice to lead to broad and more robust developmental potential relative to primed mouse epiblast cells. The human naive ES cell state has eluded derivation without the use of transgenes, and forced express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d255a2ea1015162fa00de617684bfc
https://pubmed.ncbi.nlm.nih.gov/24623855
https://pubmed.ncbi.nlm.nih.gov/24623855