Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Henrik S. Olsen"'
Autor:
Scott E. Strome, Henrik S. Olsen, Haoping Sun, Xiaoyu Zhang, John C. Papadimitriou, Erin Burch, David S. Block, Edward So, Søren M. Bentzen, Susan Kinsey, Emmanuel Y. Mérigeon, Cinthia B. Drachenberg
Publikováno v:
Journal of Autoimmunity. 84:97-108
There is a lack of effective targeted therapies for the treatment of complement dependent diseases. We developed two recombinant Fc multimers, G207 and G211, with limited ability to interact with low/moderate affinity FcγRs, but with high avidity fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8318e95b8d14d38fc8c5ca51bc586f
https://doi.org/10.1016/j.jaut.2017.08.004
https://doi.org/10.1016/j.jaut.2017.08.004
Autor:
Gregory LaRosa, Hua Zhou, Edward So, Henrik S. Olsen, Denis Rybin, David S. Block, Xiaoyu Zhang, Jane Owens, Emmanuel Y. Mérigeon, Scott E. Strome
Publikováno v:
Blood Advances. 1:504-515
GL-2045 is a recombinant human immunoglobulin G1 (IgG1)-based Fc multimer designed to recapitulate the anti-inflammatory activities of intravenous immunoglobulin (IVIG) on the innate and adaptive immune responses. We used functional in vitro studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114c97dd8e755f338f895a2c2fc5e02f
https://doi.org/10.1182/bloodadvances.2016001917
https://doi.org/10.1182/bloodadvances.2016001917
Autor:
Henrik S. Olsen, Shaodong Chen, Erin Burch, Edward So, David S. Block, Emmanuel Y. Mérigeon, Scott E. Strome, Xiaoyu Zhang, Hua Zhou
Publikováno v:
The Journal of Immunology. 196:1165-1176
We developed a fully recombinant anti-CD20 protein derived from cDNA encoding one Fab domain, two IgG1 Fc regions, the IgG2 hinge, and an isoleucine zipper. This protein, called GB4542, contained both the homodimer and higher-order multimers. Binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37493eee6ef8709ccaac959f31afb299
https://doi.org/10.4049/jimmunol.1501755
https://doi.org/10.4049/jimmunol.1501755
Autor:
Xiaoyu Zhang, Gregory Weber, David S. Block, Edward So, Erin Burch, Henrik S. Olsen, Xianfeng Li, Gregory LaRosa, Scott E. Strome, Haiping Hao, Mark C. McCroskey, Donald Bennett, Hua Zhou, Jane Owens, Emmanuel Y. Mérigeon, Denis Rybin
Publikováno v:
JCI insight. 4(2)
The antiinflammatory effects of i.v. Ig (IVIG) in the treatment of autoimmune disease are due, in part, to the Fc fragments of Ig aggregates. In order to capitalize on the known antiinflammatory and tolerogenic properties of Ig Fc aggregates, we crea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c989f5f39c64d0e8143d6fb5f25d2a
https://pubmed.ncbi.nlm.nih.gov/30674715
https://pubmed.ncbi.nlm.nih.gov/30674715
Autor:
William S. Twadell, Ling Cai, Edward So, Scott E. Strome, Xiaoyu Zhang, Dan H. Schulze, David S. Block, Bhawna Poonia, Erin Burch, Ajay N. Jain, Emmanuel Y. Mérigeon, Henrik S. Olsen, Nader Hanna, Harris G. Yfantis, Ravi Vyzasatya, Siaw L. Chan
Publikováno v:
European Journal of Cancer. 49:3344-3352
Tumour antigen targeted antibodies (mAbs) can induce natural killer (NK) cells to kill tumours through antibody dependent cellular cytotoxicity (ADCC) upon engagement of NK cell expressed FcγRIIIa. FcγRIIIa polymorphisms partially dictate the poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a8fbeb25e75c9cf23b4ff2d169e13d
https://doi.org/10.1016/j.ejca.2013.06.009
https://doi.org/10.1016/j.ejca.2013.06.009
Autor:
Henrik S. Olsen, Steven M. Ruben, Candy Lee, Paul A. Moore, Katherine McKinnon, Victoria Bushman, Jenny Heidbrink, William Fitzhugh, Karen Van Orden, Tao He, Aiqun Li
Publikováno v:
Pancreas
Objectives There is a clear need for better therapeutics and diagnostics for pancreatic cancer. We aimed to discover plasma membrane-associated proteins overexpressed in pancreatic cancer using quantitative proteomics and apply RNA interference (RNAi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16881addf187ffc4bbc371ae3b8f42f2
https://doi.org/10.1097/mpa.0b013e3182236385
https://doi.org/10.1097/mpa.0b013e3182236385
Autor:
Joe X. H. Zhou, Gordon Moody, Bernardetta Nardelli, James H. Murray, Andrew Garcia, Cynthia Sung, Henrik S. Olsen, Blaire L. Osborn, Liubov Zaritskaya
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:540-548
Interferon-alpha (IFN-alpha) is indicated for the treatment of certain viral infections including hepatitis B and C, and cancers such as melanoma. The short circulating half-life of unmodified IFN-alpha makes frequent dosing (daily or three times wee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749124b57fc90a53bd9a12ae9aea8c12
https://doi.org/10.1124/jpet.102.037002
https://doi.org/10.1124/jpet.102.037002
Publikováno v:
British Journal of Haematology. 119:359-363
Stanniocalcin-1 (STC) is a 56-kDa homodimeric glycoprotein hormone originally found in fish, in which it regulates calcium/phosphate homeostasis and protects against toxic hypercalcaemia. The recently characterized human STC is 80% similar to fish ST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3afaa8066db3ec0ccf4f1355978de95e
https://doi.org/10.1046/j.1365-2141.2002.03916.x
https://doi.org/10.1046/j.1365-2141.2002.03916.x
Autor:
Stephen Ullrich, Ping Feng, Jun Zhang, Cecil Chen, Sunghee Kim, Palanisamy Kanakaraj, Reiner L. Gentz, Jeffrey Carrell, Ding Liu, Gang Hu, Ping Wei, Paul A. Moore, Ernest Boyd, Steve Ruben, Bugen Hu, Laurie Pukac, June S. Hong, Xia Luo, Henrik S. Olsen, Joe X. H. Zhou, Yun Hee Cho, James W. Perry, Su Fang Chen, Jian Ni, Thi Sau Migone, Li Zhuang
Publikováno v:
Immunity. 16:479-492
DR3 is a death domain-containing receptor that is upregulated during T cell activation and whose overexpression induces apoptosis and NF-kappaB activation in cell lines. Here we show that an endothelial cell-derived TNF-like factor, TL1A, is a ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c88241cec70630dd53d09f456ffe6ae
https://doi.org/10.1016/s1074-7613(02)00283-2
https://doi.org/10.1016/s1074-7613(02)00283-2
Autor:
Xiao-Tao Yao, Krzysztof J. Grzegorzewski, Tina S. Morris, Linyi Zhang, Indra Sanyal, Laurie A. Brewer, Theodora W. Salcedo, Gianni Garotta, Dave Zukauskas, Brent L. Kreider, Yunsoo Kim, Gary W. Bong, Henrik S. Olsen, Bernardetta Nardelli
Publikováno v:
Cytokine. 13:209-219
Myeloid progenitor inhibitory factor (MPIF)-2 is a β-chemokine with select and potent activities on eosinophils and myeloid progenitors. In the β-chemokine family, biological activity is modulated by differential processing of the amino-terminus. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf81b9d34a320f09b35afd44123aa621
https://doi.org/10.1006/cyto.2000.0821
https://doi.org/10.1006/cyto.2000.0821