Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Henrik Oerum"'
Autor:
Adam P. Cribbs, Panagis Filippakopoulos, Martin Philpott, Graham Wells, Henry Penn, Henrik Oerum, Viia Valge-Archer, Marc Feldmann, Udo Oppermann
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural killer (NK) cells are innate lymphocytes that play a pivotal role in the immune surveillance and elimination of transformed or virally infected cells. Using a chemo-genetic approach, we identify BET bromodomain containing proteins BRD2 and BR
Externí odkaz:
https://doaj.org/article/27ac3bb7baf3417fb22ee808d526ef6c
Autor:
Stephanie Oerum, Finn Cilius Nielsen, Jan Gerstoft, Henrik Oerum, Annemette Hald, Lelde Kalnina, Àngels Mateu-Regué, Astrid K. N. Iversen
Publikováno v:
Kalnina, L, Mateu-Regué, À, Oerum, S, Hald, A, Gerstoft, J, Oerum, H, Nielsen, F C & Iversen, A K N 2021, ' A simple, safe and sensitive method for SARS-CoV-2 inactivation and RNA extraction for RT-qPCR ', APMIS, vol. 129, no. 7, pp. 393-400 . https://doi.org/10.1111/apm.13123
Apmis
Apmis
The SARS-CoV-2 pandemic has created an urgent need for diagnostic tests to detect viral RNA. Commercial RNA extraction kits are often expensive, in limited supply, and do not always fully inactivate the virus. Together, this calls for the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b0a8fca27e27168dbba50438292fb9
https://doi.org/10.1111/apm.13123
https://doi.org/10.1111/apm.13123
Autor:
Henrik Oerum, Marc Feldmann, Morten Lindow, Stefan Terlecki-Zaniewicz, David Ahern, Udo Oppermann, Pal Mander, Paul Bowness, Jeroen Baardman, Brante P. Sampey, Menno P.J. de Winther, Susanna Obad, Henry Penn, Adam P. Cribbs, Rab K. Prinjha, Paul Wordsworth, Martin Philpott
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 117(11), 6056-6066. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance T cells control many immune functions, with Th17 cells critical in regulating inflammation. Following activation, T cells undergo metabolic reprogramming and utilize glycolysis to increase the ATP availability. Epigenetic mechanisms cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36abcb281de6160ff914d6f5b8a2fa6
Autor:
Henrik Oerum, Bo Hansen, John J. Rossi, Daniela Castanotto, Min Lin, Harris S. Soifer, Cy A. Stein, Troels Koch, Zhigang Wang, Paul Bauer, LiAnn Wang, Brian Armstrong, Xiao-Qin Ren, Claudia M. Kowolik
Publikováno v:
Nucleic Acids Research
Antisense oligonucleotides (ASOs) are known to trigger mRNA degradation in the nucleus via an RNase H-dependent mechanism. We have now identified a putative cytoplasmic mechanism through which ASO gapmers silence their targets when transfected or del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd1a65a9f2c1452ce6c1b28190b9962
http://europepmc.org/articles/PMC4627093
http://europepmc.org/articles/PMC4627093
Autor:
Adam, Cribbs, Edward S, Hookway, Graham, Wells, Morten, Lindow, Susanna, Obad, Henrik, Oerum, Rab K, Prinjha, Nick, Athanasou, Aneka, Sowman, Martin, Philpott, Henry, Penn, Kalle, Soderstrom, Marc, Feldmann, Udo, Oppermann
Publikováno v:
The Journal of Biological Chemistry
Natural killer (NK) cells are innate lymphocytes, important in immune surveillance and elimination of stressed, transformed, or virus-infected cells. They critically shape the inflammatory cytokine environment to orchestrate interactions of cells of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::796dbca9b8091ba9eaec4cb53bb9fca5
https://pubmed.ncbi.nlm.nih.gov/29301935
https://pubmed.ncbi.nlm.nih.gov/29301935
Autor:
Cy A. Stein, Henrik Oerum, Min Lin, Daniela Castanotto, Claudia M. Kowolik, Troels Koch, Bo Hansen
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 24(6)
We have identified the existence of a productive, PKC-α-dependent endocytotic silencing pathway that leads gymnotically-delivered locked nucleic acid (LNA)-gapmer phosphorothioate antisense oligonucleotides (ASOs) into late endosomes. By blocking th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fa33578eebdb6b26c54b46b8d01000
https://pubmed.ncbi.nlm.nih.gov/26961407
https://pubmed.ncbi.nlm.nih.gov/26961407
Autor:
Liam Good, Tomas Hökfelt, Henrik Oerum, Alexei A. Koshkin, Frank Porreca, Jesper Wengel, Kunkun Ren, Thomas Johnsson, Michael H. Ossipov, Nana Jakobsen, Josephine Lai, Claes Wahlestedt, Johanna Kela, Christian Broberger, Mogens Havsteen Jacobsen, Peter Salmi, Jan Skouv
Publikováno v:
Proceedings of the National Academy of Sciences. 97:5633-5638
Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness. We demonstrate here that a high-affinity DNA analog, locked nucleic acid (LNA), confers several desired properties to antisense agents. Unlike DNA,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4511065dba6b23b143c097540b5c1040
https://doi.org/10.1073/pnas.97.10.5633
https://doi.org/10.1073/pnas.97.10.5633
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 22:1607-1609
Full-length and 4 nucleotides truncated Locked Nucleic Acid (LNA) modifications of ISIS 3521 were compared for antisense properties in a cellular assay. ISIS 3521 is a 20-mer phosphorothioate designed to hybridise to human protein kinase C-α (PKC-α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8b68baff9aa2b786401a68f266e663
https://doi.org/10.1081/ncn-120023045
https://doi.org/10.1081/ncn-120023045
Autor:
Harris S, Soifer, Troels, Koch, Johnathan, Lai, Bo, Hansen, Anja, Hoeg, Henrik, Oerum, C A, Stein
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 815
Antisense oligodeoxyribonucleotides have been used for decades to achieve sequence-specific silencing of gene expression. However, all early generation oligonucleotides (e.g., those with no other modifications than the phosphorothioate backbone) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8eadf8fcdeb7511247474f4ce78540c
https://pubmed.ncbi.nlm.nih.gov/22131003
https://pubmed.ncbi.nlm.nih.gov/22131003
Autor:
Harris S. Soifer, Bo Hansen, Henrik Oerum, C. A. Stein, Anja Hoeg, Johnathan C. Lai, Troels Koch
Publikováno v:
Methods in Molecular Biology ISBN: 9781617794230
Antisense oligodeoxyribonucleotides have been used for decades to achieve sequence-specific silencing of gene expression. However, all early generation oligonucleotides (e.g., those with no other modifications than the phosphorothioate backbone) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e25b1a8ada71899c1dbaf57eb916b52
https://doi.org/10.1007/978-1-61779-424-7_25
https://doi.org/10.1007/978-1-61779-424-7_25