Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Henrik Molina"'
Autor:
Zurong Wan, Jinghua Gu, Uthra Balaji, Linda Bojmar, Henrik Molina, Søren Heissel, Alexandra E. Pagano, Christopher Peralta, Lee Shaashua, Dorina Ismailgeci, Hope K. Narozniak, Yi Song, William R. Jarnagin, David P. Kelsen, Jaqueline Bromberg, Virginia Pascual, Haiying Zhang
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 7, Pp n/a-n/a (2024)
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasm
Externí odkaz:
https://doaj.org/article/95a9b12e918b4946b26a0313b16a23b8
Autor:
Linda Bojmar, Han Sang Kim, Kei Sugiura, Søren Heissel, Serena Lucotti, Michele Cioffi, Kofi Ennu Johnson, Leona Cohen-Gould, Haiying Zhang, Henrik Molina, Irina R. Matei, David Lyden, Ayuko Hoshino
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102754- (2024)
Summary: Characterization of isolated extracellular vesicles and particles (EVPs) is crucial for determining functions and biomarker potential. Here, we present a protocol to analyze size, number, morphology, and EVP protein cargo and to validate EVP
Externí odkaz:
https://doaj.org/article/bd44e6608aab453fbb65260be70b9ae9
Autor:
Krithika Venkataraman, Nadav Shai, Priyanka Lakhiani, Sarah Zylka, Jieqing Zhao, Margaret Herre, Joshua Zeng, Lauren A Neal, Henrik Molina, Li Zhao, Leslie B Vosshall
Publikováno v:
eLife, Vol 12 (2023)
Female Aedes aegypti mosquitoes impose a severe global public health burden as vectors of multiple viral pathogens. Under optimal environmental conditions, Aedes aegypti females have access to human hosts that provide blood proteins for egg developme
Externí odkaz:
https://doaj.org/article/df8d2a079d314c448888cfedafdfbf56
Autor:
Chan Hee J Choi, William Barr, Samir Zaman, Corey Model, Annsea Park, Mascha Koenen, Zeran Lin, Sarah K Szwed, Francois Marchildon, Audrey Crane, Thomas S Carroll, Henrik Molina, Paul Cohen
Publikováno v:
eLife, Vol 11 (2022)
While dysregulation of adipocyte endocrine function plays a central role in obesity and its complications, the vast majority of adipokines remain uncharacterized. We employed bio-orthogonal non-canonical amino acid tagging (BONCAT) and mass spectrome
Externí odkaz:
https://doaj.org/article/c6f61321c017407b97cd6735f2779d52
Autor:
James Russell, Louise Fanchon, Hanan Alwaseem, Henrik Molina, Isabella O’Donoghue, Amber Bahr, Elisa deStanchina, Nagavarakishore Pillarsetty, John L. Humm
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 2, Pp n/a-n/a (2022)
Abstract Previously published digital autoradiography of 3H‐labeled capecitabine reveals a near‐uniform distribution of activity throughout a murine pancreatic model. This is in contrast both to 14C‐labeled gemcitabine, and established expectat
Externí odkaz:
https://doaj.org/article/9a2617618920471fbdb6fb46405f3a90
Autor:
Viet Loan Dao Thi, Xianfang Wu, Rachel L. Belote, Ursula Andreo, Constantin N. Takacs, Joseph P. Fernandez, Luis Andre Vale-Silva, Sarah Prallet, Charlotte C. Decker, Rebecca M. Fu, Bingqian Qu, Kunihiro Uryu, Henrik Molina, Mohsan Saeed, Eike Steinmann, Stephan Urban, Roshni R. Singaraja, William M. Schneider, Sanford M. Simon, Charles M. Rice
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
To model hepatocyte function accurately in vitro, it is necessary to generate and maintain a polarized epithelium. Here, the authors describe a protocol to generate polarized human pluripotent stem cell-derived hepatocyte-like cells (HLCs) to model e
Externí odkaz:
https://doaj.org/article/d2bbfc7838fb493fa97035285b6d1783
Autor:
Mohsan Saeed, Sebastian Kapell, Nicholas T Hertz, Xianfang Wu, Kierstin Bell, Alison W Ashbrook, Milica Tesic Mark, Henry A Zebroski, Maxwell L Neal, Malin Flodström-Tullberg, Margaret R MacDonald, John D Aitchison, Henrik Molina, Charles M Rice
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008927 (2020)
Viruses cleave cellular proteins to remodel the host proteome. The study of these cleavages has revealed mechanisms of immune evasion, resource exploitation, and pathogenesis. However, the full extent of virus-induced proteolysis in infected cells is
Externí odkaz:
https://doaj.org/article/a0af98e83ecb4080aebefd1e79bfc91f
Autor:
Eve-Ellen Govek, Zhuhao Wu, Devrim Acehan, Henrik Molina, Keith Rivera, Xiaodong Zhu, Yin Fang, Marc Tessier-Lavigne, Mary Elizabeth Hatten
Publikováno v:
iScience, Vol 1, Iss , Pp 35-48 (2018)
Summary: CNS cortical histogenesis depends on polarity signaling pathways that regulate cell adhesion and motility. Here we report that conditional deletion of the Rho GTPase Cdc42 in cerebellar granule cell precursors (GCPs) results in abnormalities
Externí odkaz:
https://doaj.org/article/0da546b96851415b8f4d8fff7ae605a9
Autor:
Woelsung Yi, Sanjay Gupta, Edd Ricker, Michela Manni, Rolf Jessberger, Yurii Chinenov, Henrik Molina, Alessandra B. Pernis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Excessive expansion of the T follicular helper (TFH) cell pool is associated with autoimmune disease and Def6 has been identified as an SLE risk variant. Here the authors show that Def6 limits proliferation of TFH cells in mice via alteration of mTOR
Externí odkaz:
https://doaj.org/article/d8898e9c90074000ad87e4d3b1cd931c
Autor:
Aitor Garzia, Seyed Mehdi Jafarnejad, Cindy Meyer, Clément Chapat, Tasos Gogakos, Pavel Morozov, Mehdi Amiri, Maayan Shapiro, Henrik Molina, Thomas Tuschl, Nahum Sonenberg
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Translation of aberrant mRNAs causes ribosome stalling and translation arrest, followed by recycling of the stalled ribosome complex. Here the authors show that the Zinc Finger Protein 598 (ZNF598/Hel2) is implicated in sensing faulty translation of
Externí odkaz:
https://doaj.org/article/f79858e0db6542bdb89c353b12ea9953