Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model

Autor: Anna Katri, Aneta Dąbrowska, Henrik Löfvall, Ming Ding, Morten A. Karsdal, Kim V. Andreassen, Christian S. Thudium, Kim Henriksen

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-11 (2019)

Abstract Background Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not

Externí odkaz: https://doaj.org/article/d2f8e1df135e4b248f9d99d386c05104

GPDPLQ1237—A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro

Autor: Tina Manon-Jensen, Henrik Löfvall, Yunyun Luo, Anna Katri, Yi He, Kim Henriksen, Anne-Christine Bay-Jensen, Morten Hanefeld Dziegiel, Christian S. Thudium, Aneta Dąbrowska, Morten A. Karsdal

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports; 9, no 3050 (2019)
Löfvall, H, Katri, A, Dąbrowska, A, Karsdal, M A, Luo, Y, He, Y, Manon-Jensen, T, Dziegiel, M H, Bay-Jensen, A-C, Thudium, C S & Henriksen, K 2019, ' GPDPLQ 1237-A Type II Collagen Neo-Epitope Biomarker of Osteoclast-and Inflammation-Derived Cartilage Degradation in vitro ', Scientific Reports, vol. 9, no. 1, 3050 . https://doi.org/10.1038/s41598-019-39803-0
Scientific Reports

C-telopeptide of type II collagen (CTX-II) has been shown to be a highly relevant biomarker of cartilage degradation in human rheumatic diseases, if measured in synovial fluid or urine. However, serum or plasma CTX-II have not been demonstrated to ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac9d018e3dce0f572dae79cfa6aad08
http://link.springer.com/article/10.1038/s41598-019-39803-0

Forced expression of human macrophage colony-stimulating factor in CD34+cells promotes monocyte differentiation in vitro and in vivo but blunts osteoclastogenesis in vitro

Autor: Axel Schambach, Ilana Moscatelli, Kim Henriksen, Johan Richter, Carmen P. Montano Almendras, Christian S. Thudium, Henrik Löfvall

Publikováno v: European Journal of Haematology. 98:517-526

Objectives Here we tested the hypothesis that human M-CSF (hM-CSF) overexpressed in CB CD34+ cells would induce differentiation and survival of monocytes and osteoclasts in vitro and in vivo. Methods Human M-CSF was overexpressed in cord blood CD34+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f503539c3b35585c8d1d0d2133a2964c
https://doi.org/10.1111/ejh.12867

Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model

Autor: Aneta Dąbrowska, Christian S. Thudium, Ming Ding, Henrik Löfvall, Kim Vietz Andreassen, Anna Katri, Kim Henriksen, Morten A. Karsdal

Publikováno v: Arthritis Research & Therapy
Arthritis Research & Therapy; 21(1), no 68 (2019)
Katri, A, Dąbrowska, A, Löfvall, H, Ding, M, Karsdal, M A, Andreassen, K V, Thudium, C S & Henriksen, K 2019, ' Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model. ', Arthritis Research & Therapy, vol. 21, 68 . https://doi.org/10.1186/s13075-019-1819-9
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-11 (2019)

Background Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946adb4900235c5a4e1887e6eedd9bde

Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes

Autor: Morten Hanefeld Dziegiel, Henrik Löfvall, Morten A. Karsdal, Kim Henriksen, Hannah Newbould, Christian S. Thudium, Johan Richter

Publikováno v: Löfvall, H, Newbould, H, Karsdal, M A, Dziegiel, M H, Richter, J, Henriksen, K & Thudium, C S 2018, ' Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes ', Arthritis Research and Therapy, vol. 20, 67, pp. 1-13 . https://doi.org/10.1186/s13075-018-1564-5
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-13 (2018)
Arthritis Research & Therapy

Background: Osteoclasts have been strongly implicated in osteoarthritic cartilage degradation, at least indirectly via bone resorption, and have been shown to degrade cartilage in vitro. The osteoclast resorption processes required to degrade subchon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a788e416e7597c4c1386cccae7bb45
https://curis.ku.dk/ws/files/214752253/Lofvall_Osteoclasts.pdf