Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Henrik Duelund Pedersen"'
Autor:
Ditte Olsen Lützhøft, Cecilie Bækgård, Elizabeth Wimborne, Ellen Marie Straarup, Karen-Margrethe Pedersen, Jonathan R Swann, Henrik Duelund Pedersen, Kim Kristensen, Line Morgills, Dennis Sandris Nielsen, Axel Kornerup Hansen, Marianne Kronborg Bracken, Susanna Cirera, Berit Østergaard Christoffersen
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0298602 (2024)
The objectives were 1) to characterize a Göttingen Minipig model of metabolic syndrome regarding its colon microbiota and circulating microbial products, and 2) to assess whether ovariectomized female and castrated male minipigs show similar phenoty
Externí odkaz:
https://doaj.org/article/90a2b8f6cca8471cb76ca51ffe9a1c22
Autor:
Berit Østergaard Christoffersen, Camilla Aarup Kristensen, Rikke Lindgaard, Rikke Kaae Kirk, Birgitte Martine Viuff, Peter Helding Kvist, Henrik Duelund Pedersen, Trine Pagh Ludvigsen, Tine Skovgaard, Johannes Josef Fels, Torben Martinussen, Liselotte Bruun Christiansen, Susanna Cirera, Lisbeth Høier Olsen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Obesity-related glomerulopathy and diabetic nephropathy (DN) are serious complications to metabolic syndrome and diabetes. The purpose was to study effects of a fat, fructose and cholesterol-rich (FFC) diet with and without salt in order to
Externí odkaz:
https://doaj.org/article/3861ec5ca819498892ae65a84336efb9
Autor:
Ditte Olsen Lützhøft, Tim Sinioja, Berit Ø. Christoffersen, Rasmus Riemer Jakobsen, Dawei Geng, Hajar Fauzan Bin Ahmad, Ellen Marie Straarup, Karen-Margrethe Pedersen, Witold Kot, Henrik Duelund Pedersen, Susanna Cirera, Tuulia Hyötyläinen, Dennis Sandris Nielsen, Axel Kornerup Hansen
Publikováno v:
BMC Microbiology, Vol 22, Iss 1, Pp 1-14 (2022)
Abstract Background Gut microbiota dysbiosis is associated with the development of non-alcoholic steatohepatitis (NASH) through modulation of gut barrier, inflammation, lipid metabolism, bile acid signaling and short-chain fatty acid production. The
Externí odkaz:
https://doaj.org/article/a931ba6e887e454d981730582c3cb040
Autor:
Camilla Schumacher-Petersen, Berit Østergaard Christoffersen, Rikke Kaae Kirk, Trine Pagh Ludvigsen, Nora Elisabeth Zois, Henrik Duelund Pedersen, Mogens Vyberg, Lisbeth Høier Olsen
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-18 (2019)
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in humans, and ranges from steatosis to non-alcoholic steatohepatitis (NASH), the latter with risk of progression to cirrhosis. The Göttingen Minipig has
Externí odkaz:
https://doaj.org/article/326b19047b2d482a8f7928175761c3b5
Autor:
Laura Jul Andreasen, Simone Krog, Trine Pagh Ludvigsen, Ole Lerberg Nielsen, Jacob Eifer Møller, Berit Østergaard Christoffersen, Henrik Duelund Pedersen, Lisbeth Høier Olsen
Publikováno v:
Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-12 (2018)
Abstract Background Dietary interventions have been shown to attenuate some of the myocardial pathological alterations associated with obesity. This study evaluated the effect of dietary normalization from a fat/fructose/cholesterol-rich diet to chow
Externí odkaz:
https://doaj.org/article/2f4c217f685f452985a16d51505e2514
Autor:
Michelle Fischer, Carlsen, Berit Østergaard, Christoffersen, Rikke, Lindgaard, Henrik Duelund, Pedersen, Lisbeth Høier, Olsen
Publikováno v:
Carlsen, M F, Christoffersen, B Ø, Lindgaard, R, Pedersen, H D & Olsen, L H 2022, ' Implantation of telemetric blood pressure transmitters in Göttingen Minipigs : Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia ', Journal of Pharmacological and Toxicological Methods, vol. 115, 107168 . https://doi.org/10.1016/j.vascn.2022.107168
INTRODUCTION: Porcine animal models are used in biomedical research due to anatomical and physiological similarities with human patients. The study aimed to validate telemetric systemic blood pressure (BP) and heart rate (HR) monitoring in Göttingen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8998369cd7b5bd6d00ffc672a7cfa3
https://doi.org/10.1016/j.vascn.2022.107168
https://doi.org/10.1016/j.vascn.2022.107168
Autor:
Peter Vestbjerg, Claire Friry-Santini, Philippe Ancian, Hollie Skaggs, Jacques Descotes, Antonio Iglesias, Henrik Duelund Pedersen, Tina Rubic-Schneider, Linda Allais
Publikováno v:
Regulatory Toxicology and Pharmacology. 94:271-275
There is a growing need to consider non-rodent species for the immunological safety evaluation of drug candidates. The EU Framework-6 RETHINK Project demonstrated that the Gottingen Minipig is a relevant animal model for regulatory toxicology studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5ddbc677f49ecce5d3cc93bf909159
https://doi.org/10.1016/j.yrtph.2018.02.015
https://doi.org/10.1016/j.yrtph.2018.02.015
Autor:
Arturo Anadón, Vellareddy Anantharam, Anthony E. Archibong, Irma Ares, Adam D. Aulbach, Nikee Awasthee, Aryamitra Banerjee, Leah D. Banks, Frank A. Barile, Sudheer R. Beedanagari, Charalampos Belantis, Enrico Bergamaschi, Sadikshya Bhandari, Sneha P. Bhatia, Karyn Bischoff, David J. Borts, Emily Brehm, Subash Chandra Gupta, Saurabh Chatterjee, Catheryne Chiang, Anirudh J. Chintalapati, P. Cohn, Robert W. Coppock, Lucio G. Costa, Tirupapuliyur V. Damodaran, Clinton D'Souza, Wolf-D. Dettbarn, Amy A. Devlin, Robin B. Doss, Shiwangi Dwivedi, Margitta M. Dziwenka, Jorge Estévez, Daniel S. Fabricant, A.M. Fan, Vanessa A. Fitsanakis, John Flaskos, Jodi A. Flaws, Swaran J.S. Flora, Sue M. Ford, Jessica S. Fortin, Domniki Fragou, Shayne C. Gad, Bianca Galateanu, Dale R. Gardner, George Georgiadis, Fernando Gil, Saryu Goel, Mary Gulumian, P.K. Gupta, Ramesh C. Gupta, Rekha K. Gupta, Sharon Gwaltney-Brant, Alan J. Hargreaves, Kelly L. Harris, Kenneth J. Harris, Holly E. Hatfield, Wallace A. Hayes, Ioannis Heretis, Antonio F. Hernández, Corey J. Hilmas, Darryl B. Hood, Pasi Huuskonen, Stewart B. Jacobson, Sandra A. James-Yi, Huajun Jin, Jun Kanno, Arthi Kanthasamy, Anumantha G. Kanthasamy, Shilpa N. Kaore, Navinchandra M. Kaore, Bhupendra S. Kaphalia, Vesa Karttunen, Gurjot Kaur, Ravneet Kaur, Prasada Rao S. Kodavanti, Urmila P. Kodavanti, George A. Kontadakis, Gopala Krishna, Priya A. Krishna, Kavya A. Krishna, Maria Kummu, George D. Kymionis, Rajiv Lall, P. Lin, Bommanna G. Loganathan, Jarkko Loikkanen, Marcello Lotti, Michael A. Lynes, Brinda Mahadevan, Jitendra K. Malik, Charalampos Mamoulakis, Jane A. Mantey, María Rosa Martínez-Larrañaga, María Aránzazu Martínez, Charalampos Mavridis, Roger O. McClellan, Vincent P. Meador, Lars Friis Mikkelsen, Dejan Milatovic, Ida R. Miller Mukherjee, Anupama Mukherjee, Pushpinder Kaur Multani, Päivi Myllynen, Kirsi Myöhänen, Rekek Negga, Carolina Negrei, Meliton N. Novilla, Stephanie Padilla, Carlos M. Palmeira, Kip E. Panter, Markku Pasanen, Daniel J. Patrick, Sofia Pavanello, Henrik Duelund Pedersen, Olavi Pelkonen, Michael A. Pellizzon, Jason Pitt, Argyro Plaka, Aramandla Ramesh, Saniya Rattan, Jenni Repo, Matthew R. Ricci, Anabela P. Rolo, Magdalini Sachana, Heidi Sahlman, Nitin Saini, Vandana Saini, Kai Savolainen, Ratanesh Kumar Seth, Abha Sharma, Anurag Sharma, Elina Sieppi, Rui Silva, Anita Sinha, Iordanis Skamagkas, Samantha J. Snow, Miguel A. Sogorb, Ajay Srivastava, Szabina A. Stice, Markus Storvik, David T. Szabo, João S. Teodoro, Aristidis M. Tsatsakis, John Tsiaoussis, Kirsi Vähäkangas, Sumit Singh Verma, Eugenio Vilanova, Suryanarayana V. Vulimiri, Genoa R. Warner, Kevin D. Welch, Christina Wilson-Frank, S.H. You, Snjezana Zaja-Milatovic, Ioannis E. Zisis, Csaba K. Zoltani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5da5a009880ef9604908d9dca3addf8c
https://doi.org/10.1016/b978-0-12-814655-2.01002-1
https://doi.org/10.1016/b978-0-12-814655-2.01002-1
The Gottingen Minipig is globally the most widely used minipig for toxicity testing since it is rather small and well-defined genetically as well as microbiologically. Also, both pigs and minipigs resemble humans in many aspects of anatomy and physio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39043ceb51265a395c610e708c6a9d1c
https://doi.org/10.1016/b978-0-12-814655-2.00003-7
https://doi.org/10.1016/b978-0-12-814655-2.00003-7
Autor:
Gary D. Lopaschuk, Spencer D. Proctor, Lene Nygaard Axelsen, Henrik Duelund Pedersen, Niels-Henrik Holstein-Rathlou, Eddi Meier, Ditte Riber, Anne Louise Kjølbye, Wendy Keung, Joergen Soeberg Petersen
Publikováno v:
British Journal of Pharmacology. 165:2736-2748
BACKGROUND AND PURPOSE The prevalence of heart disease continues to rise, particularly in subjects with insulin resistance (IR), and improved therapies for these patients is an important challenge. In this study we evaluated cardiac function and ener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dff80f1ff45d4f680b23738860053a7
https://doi.org/10.1111/j.1476-5381.2011.01714.x
https://doi.org/10.1111/j.1476-5381.2011.01714.x