Výsledky vyhledávání - "Henrik Dahl Pinholt"

Akademický článek

Enhanced hexamerization of insulin via assembly pathway rerouting revealed by single particle studies

Autor: Freja Bohr, Søren S. -R. Bohr, Narendra Kumar Mishra, Nicolás Sebastian González-Foutel, Henrik Dahl Pinholt, Shunliang Wu, Emilie Milan Nielsen, Min Zhang, Magnus Kjaergaard, Knud J. Jensen, Nikos S. Hatzakis

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)

Single-molecule studies reveal the pathway organization of self-assembly and disassembly of insulin hexamers and how this is remodeled by regulatory cues and formulations. The abundance of all oligomeric species as well their kinetics are assessed.

Externí odkaz: https://doaj.org/article/a2c4283706f740dcac2882e75c3bfc65

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Heterogeneous and Surface-Catalyzed Amyloid Aggregation Monitored by Spatially Resolved Fluorescence and Single Molecule Microscopy

Autor: Xin Zhou, Anders Wilgaard Sinkjær, Min Zhang, Henrik Dahl Pinholt, Hanne Mørck Nielsen, Nikos S. Hatzakis, Marco van de Weert, Vito Foderà

Publikováno v: The Journal of Physical Chemistry Letters. 14:912-919

Amyloid aggregation is associated with many diseases and may also occur in therapeutic protein formulations. Addition of co-solutes is a key strategy to modulate the stability of proteins in pharmaceutical formulations and select inhibitors for drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d60825827aa615f8013a41bbc9751d
https://doi.org/10.1021/acs.jpclett.2c03400

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Direct observation of heterogeneous formation of amyloid spherulites in real-time by super-resolution microscopy

Autor: Min Zhang, Soeren S-R Bohr, Henrik Dahl Pinholt, Vito Foderà, Xin Zhou, Alessio Zaccone, Nikos S. Hatzakis, Luca Banneta

Publikováno v: Zhang, M, Pinholt, H, Zhou, X, Bohr, S, Banetta, L, Zaccone, A, Fodera, V & Hatzakis, N 2022, ' Direct observation of heterogeneous formation of amyloid spherulites in real-time by super-resolution microscopy ', Communications Biology, vol. 5, no. 1, 850 . https://doi.org/10.1038/s42003-022-03810-1

Real-time super-resolution microscopy analysis reveals the growth kinetics, morphology, and abundance of human insulin amyloid spherulites with different growth pathways.Protein misfolding in the form of fibrils or spherulites is involved in a spectr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be7e5d0a19ffbdebbcd6c8152fcd294
https://hdl.handle.net/2434/944637

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Single-particle diffusional fingerprinting:A machine-learning framework for quantitative analysis of heterogeneous diffusion

Autor: Henrik Dahl Pinholt, Søren S.-R. Bohr, Wouter Boomsma, Nikos S. Hatzakis, Josephine F. Iversen

Publikováno v: Pinholt, H D, Bohr, S S R, Iversen, J F, Boomsma, W & Hatzakis, N S 2021, ' Single-particle diffusional fingerprinting : A machine-learning framework for quantitative analysis of heterogeneous diffusion ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 31, e2104624118 . https://doi.org/10.1073/pnas.2104624118
Proceedings of the National Academy of Sciences of the United States of America

Significance Single-particle tracking (SPT) analysis of individual biomolecules is an indispensable tool for extracting quantitative information from dynamic biological processes, but often requires some a priori knowledge of the system. Here we pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a76e28f99bd3b920f99dc95b4822d8
https://curis.ku.dk/portal/da/publications/singleparticle-diffusional-fingerprinting(44a0e005-e56c-4eb0-a4db-0880645ad92b).html

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Direct observation of Thermomyces lanuginosus lipase diffusional states by Single Particle Tracking and their remodeling by mutations and inhibition

Autor: Allan Svendsen, Johannes Thomsen, Søren S.-R. Bohr, Nikos S. Hatzakis, Henrik Dahl Pinholt, Sune M. Christensen, Amalie S. Kallenbach, Lars Iversen, Philip M. Lund

Publikováno v: Bohr, S S-R, Lund, P M, Kallenbach, A S, Pinholt, H, Thomsen, J, Iversen, L, Svendsen, A, Christensen, S M & Hatzakis, N S 2019, ' Direct observation of Thermomyces lanuginosus lipase diffusional states by Single Particle Tracking and their remodeling by mutations and inhibition ', Scientific Reports, vol. 9, 16169 . https://doi.org/10.1038/s41598-019-52539-1
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

Lipases are interfacially activated enzymes that catalyze the hydrolysis of ester bonds and constitute prime candidates for industrial and biotechnological applications ranging from detergent industry, to chiral organic synthesis. As a result, there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a92db2807417714a506d286593b8a73
https://doi.org/10.1038/s41598-019-52539-1

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'Turing mechanisms under pressure': Mesenchymal condensations could be involved in digit patterning of mice

Autor: Henrik Dahl Pinholt

Publikováno v: BASE-Bielefeld Academic Search Engine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::469d3d4700bfa7c58913f668f9a520c0
https://tidsskrift.dk/nanovidenskabKU/article/view/111789

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