Zobrazeno 1 - 10
of 543
pro vyhledávání: '"Henrik Clausen"'
Autor:
Janneke Elzinga, Yoshiki Narimatsu, Noortje de Haan, Henrik Clausen, Willem M. de Vos, Hanne L. P. Tytgat
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The intestinal anaerobic bacterium Akkermansia muciniphila is specialized in the degradation of mucins, which are heavily O-glycosylated proteins that constitute the major components of the mucus lining the intestine. Despite that adhesion t
Externí odkaz:
https://doaj.org/article/c8bb4d1d26f248979f337e88123131ad
Autor:
Gergely N. Nagy, Xiao-Feng Zhao, Richard Karlsson, Karen Wang, Ramona Duman, Karl Harlos, Kamel El Omari, Armin Wagner, Henrik Clausen, Rebecca L. Miller, Roman J. Giger, E. Yvonne Jones
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Integration of extracellular signals by neurons is pivotal for brain development, plasticity, and repair. Axon guidance relies on receptor-ligand interactions crosstalking with extracellular matrix components. Semaphorin-5A (Sema5A) is a bif
Externí odkaz:
https://doaj.org/article/d0014628dc274c4f9797556a14a52d87
Autor:
Daniel Madriz Sørensen, Christian Büll, Thomas D. Madsen, Erandi Lira-Navarrete, Thomas Mandel Clausen, Alex E. Clark, Aaron F. Garretson, Richard Karlsson, Johan F. A. Pijnenborg, Xin Yin, Rebecca L. Miller, Sumit K. Chanda, Thomas J. Boltje, Katrine T. Schjoldager, Sergey Y. Vakhrushev, Adnan Halim, Jeffrey D. Esko, Aaron F. Carlin, Ramon Hurtado-Guerrero, Roberto Weigert, Henrik Clausen, Yoshiki Narimatsu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Here, the authors discover small molecules that inhibit glycosylation processes that occur in the Golgi apparatus of cells. The molecules reversibly inhibit formation of elaborate glycan structures without affecting secretion of glycoproteins.
Externí odkaz:
https://doaj.org/article/6c4688dc07fc45e1bcff09858f02a146
Autor:
Víctor Taleb, Qinghua Liao, Yoshiki Narimatsu, Ana García-García, Ismael Compañón, Rafael Junqueira Borges, Andrés Manuel González-Ramírez, Francisco Corzana, Henrik Clausen, Carme Rovira, Ramon Hurtado-Guerrero
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
AM0627 is a bis-O-glycan mucinase that might work in the final steps of mucus degradation, thereby providing a carbon and nitrogen source for Akkermansia muciniphila. Here, the authors provide molecular insights into AM0627 function from X-ray crysta
Externí odkaz:
https://doaj.org/article/51738a196d424c47bf488285e9c058f0
Autor:
Mengying Liu, Liane Z. X. Huang, Anthony A. Smits, Christian Büll, Yoshiki Narimatsu, Frank J. M. van Kuppeveld, Henrik Clausen, Cornelis A. M. de Haan, Erik de Vries
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
It is believed that human Influenza HA glycoprotein attaches to alpha2-6 linked sialic acids (SA) on cells, while avian viruses bind to alpha2-3 linked sialic acids, therewith contributing to host tropism. Here, Liu et al. show that mixing low-affini
Externí odkaz:
https://doaj.org/article/5f264ad116df499eba4eda0bda36111d
Autor:
Katrien C. K. Poelaert, Regina G. D. M. van Kleef, Mengying Liu, Arno van Vliet, Heyrhyoung Lyoo, Lora-Sophie Gerber, Yoshiki Narimatsu, Christian Büll, Henrik Clausen, Erik de Vries, Remco H. S. Westerink, Frank J. M. van Kuppeveld
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Enterovirus D68 (EV-D68) is an emerging pathogen associated with mild to severe respiratory disease. Since 2014, EV-D68 is also linked to acute flaccid myelitis (AFM), causing paralysis and muscle weakness in children. However, it remains un
Externí odkaz:
https://doaj.org/article/aa3c5d37a7934c0eacc5a321ef01fbd8
Autor:
Andrés Manuel González-Ramírez, Ana Sofia Grosso, Zhang Yang, Ismael Compañón, Helena Coelho, Yoshiki Narimatsu, Henrik Clausen, Filipa Marcelo, Francisco Corzana, Ramon Hurtado-Guerrero
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The glycosyltransferase C1GalT1 directs a key step in protein O-glycosylation important for the expression of the cancer-associated Tn and T antigens. Here, the authors provide molecular insights into the function of C1GalT1 by solving the crystal st
Externí odkaz:
https://doaj.org/article/434ef961152243cdb9d73fa318291dc9
Autor:
Yen-Hsi Chen, Weihua Tian, Makiko Yasuda, Zilu Ye, Ming Song, Ulla Mandel, Claus Kristensen, Lorenzo Povolo, André R. A. Marques, Tomislav Čaval, Albert J. R. Heck, Julio Lopes Sampaio, Ludger Johannes, Takahiro Tsukimura, Robert Desnick, Sergey Y. Vakhrushev, Zhang Yang, Henrik Clausen
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Currently available enzyme replacement therapies for lysosomal storage diseases are limited in their effectiveness due in part to short circulation times and suboptimal biodistribution of the therapeutic enzymes. We previously engineered Chinese hams
Externí odkaz:
https://doaj.org/article/8ae81d7ac9d04563824966c741e0198e
Autor:
Helena Coelho, Matilde de las Rivas, Ana S. Grosso, Ana Diniz, Cátia O. Soares, Rodrigo A. Francisco, Jorge S. Dias, Ismael Compañon, Lingbo Sun, Yoshiki Narimatsu, Sergey Y. Vakhrushev, Henrik Clausen, Eurico J. Cabrita, Jesús Jiménez-Barbero, Francisco Corzana, Ramon Hurtado-Guerrero, Filipa Marcelo
Publikováno v:
JACS Au, Vol 2, Iss 3, Pp 631-645 (2022)
Externí odkaz:
https://doaj.org/article/8de70b518a0446919b119115a62fd2b1
Autor:
Julie Van Coillie, Morten A. Schulz, Arthur E. H. Bentlage, Noortje de Haan, Zilu Ye, Dionne M. Geerdes, Wim J. E. van Esch, Lise Hafkenscheid, Rebecca L. Miller, Yoshiki Narimatsu, Sergey Y. Vakhrushev, Zhang Yang, Gestur Vidarsson, Henrik Clausen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunoglobulins G (IgG) and their Fc gamma receptors (FcγRs) play important roles in our immune system. The conserved N-glycan in the Fc region of IgG1 impacts interaction of IgG with FcγRs and the resulting effector functions, which has led to the
Externí odkaz:
https://doaj.org/article/d3ca065183164628bb92e4118236f671