Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Henrik, Paavilainen"'
Autor:
Jussi Palomäki, Kiira Kalke, Julius Orpana, Liisa Lund, Fanny Frejborg, Henrik Paavilainen, Hannu Järveläinen, Veijo Hukkanen
Publikováno v:
Microorganisms, Vol 11, Iss 11, p 2657 (2023)
Herpes simplex virus (HSV) has proven successful in treating human cancer. Since the approval of talimogene laherparepvec (T-VEC) in 2015, HSV has been thoroughly researched to discover novel mechanisms to combat cancer and treat other diseases. Anot
Externí odkaz:
https://doaj.org/article/3687b63411334dddb2f30f242f5a0084
Autor:
Kiira Kalke, Liisa M Lund, Marie C Nyman, Alesia A Levanova, Arto Urtti, Minna M Poranen, Veijo Hukkanen, Henrik Paavilainen
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010688 (2022)
Herpes simplex virus type 1 (HSV-1) is a common virus of mankind and HSV-1 infections are a significant cause of blindness. The current antiviral treatment of herpes infection relies on acyclovir and related compounds. However, acyclovir resistance e
Externí odkaz:
https://doaj.org/article/02e880cb9ba6495f80428664759abb33
Autor:
Kiira Kalke, Julius Orpana, Tuomas Lasanen, Olaya Esparta, Liisa M. Lund, Fanny Frejborg, Tytti Vuorinen, Henrik Paavilainen, Veijo Hukkanen
Publikováno v:
Viruses, Vol 14, Iss 6, p 1290 (2022)
Herpes simplex virus type 1 (HSV-1) is the only FDA- and EMA- approved oncolytic virus, and accordingly, many potential oncolytic HSVs (oHSV) are in clinical development. The utilized oHSV parental strains are, however, mostly based on laboratory ref
Externí odkaz:
https://doaj.org/article/02f7d980b12c4edf8769eb6592363c9b
Autor:
Kiira Kalke, Jenni Lehtinen, Jelena Gnjatovic, Liisa M. Lund, Marie C. Nyman, Henrik Paavilainen, Julius Orpana, Tuomas Lasanen, Fanny Frejborg, Alesia A. Levanova, Tytti Vuorinen, Minna M. Poranen, Veijo Hukkanen
Publikováno v:
Viruses, Vol 12, Iss 12, p 1434 (2020)
Acyclovir is the drug of choice for the treatment of herpes simplex virus (HSV) infections. Acyclovir-resistant HSV strains may emerge, especially during long-term drug use, and subsequently cause difficult-to-treat exacerbations. Previously, we set
Externí odkaz:
https://doaj.org/article/a8340c0906c84b6299a226705499c641
Autor:
Daria Bulanova, Aleksandr Ianevski, Andrii Bugai, Yevhen Akimov, Suvi Kuivanen, Henrik Paavilainen, Laura Kakkola, Jatin Nandania, Laura Turunen, Tiina Ohman, Hanna Ala-Hongisto, Hanna M. Pesonen, Marika S. Kuisma, Anni Honkimaa, Emma L. Walton, Valentyn Oksenych, Martina B. Lorey, Dmitry Guschin, Jungmin Shim, Jinhee Kim, Thoa T. Than, So Young Chang, Veijo Hukkanen, Evgeny Kulesskiy, Varpu S. Marjomaki, Ilkka Julkunen, Tuula A. Nyman, Sampsa Matikainen, Jani S. Saarela, Famara Sane, Didier Hober, Gülsah Gabriel, Jef K. De Brabander, Miika Martikainen, Marc P. Windisch, Ji-Young Min, Roberto Bruzzone, Tero Aittokallio, Markus Vähä-Koskela, Olli Vapalahti, Arto Pulk, Vidya Velagapudi, Denis E. Kainov
Publikováno v:
Viruses, Vol 9, Iss 10, p 271 (2017)
Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-ap
Externí odkaz:
https://doaj.org/article/a2efcfb6a1b5438e8d4582f4bed8125b
Autor:
Michaela Nygårdas, Henrik Paavilainen, Nadine Müther, Claus-Henning Nagel, Matias Röyttä, Beate Sodeik, Veijo Hukkanen
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64200 (2013)
Herpes simplex virus type 1 (HSV-1) has properties that can be exploited for the development of gene therapy vectors. The neurotropism of HSV enables delivery of therapeutic genes to the nervous system. Using a bacterial artificial chromosome (BAC),
Externí odkaz:
https://doaj.org/article/f68e157352fd47a3830a6bacbd134747
Autor:
Alesia Romanovskaya, Henrik Paavilainen, Michaela Nygårdas, Dennis H Bamford, Veijo Hukkanen, Minna M Poranen
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e51019 (2012)
RNA interference (RNAi)-based sequence-specific gene silencing is applied to identify gene function and also possesses great potential for inhibiting virus replication both in animals and plants. Small interfering RNA (siRNA) molecules are the induce
Externí odkaz:
https://doaj.org/article/af84b84cbc8b49ddb5b8b9edf0c38f9a
Autor:
Laura Kakkola, Suvi Kuivanen, Hannimari Kallio-Kokko, Mira Laajala, Andres Merits, Anders Bergqvist, Uga Dumpis, Pille Letjuka, Henrik Paavilainen, Astra Vitkauskiene, Kaidi Telling, Varpu Marjomäki, Magnar Bjørås, Eva Zusinaite, Valentyn Oksenych, Kåre Bondeson, Natalja Metelitsa, Mårten Strand, Olli Vapalahti, Mona Teppor, Anu Kantele, Svein Arne Nordbø, Veijo Hukkanen, Hilde Lysvand, Aleksandr Ianevski, Magnus Evander, Denis E. Kainov, Irja Lutsar, Christina Öhrmalm, Tero Aittokallio, Ilkka Julkunen, Miia Valkonen, Rebecca Jane Cox, Tanel Tenson
Publikováno v:
Antiviral Research
According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b068bcc7d3e2c64896e3f2737533685d
https://doi.org/10.1016/j.antiviral.2018.04.016
https://doi.org/10.1016/j.antiviral.2018.04.016
Autor:
Veijo Hukkanen, Michaela Nygårdas, Dennis H. Bamford, Jenni Lehtinen, Minna M. Poranen, Henrik Paavilainen, Alesia Romanovskaya
Publikováno v:
Antiviral Therapy. 22:631-637
Background Herpes simplex virus (HSV) is a common human pathogen. Despite current antivirals, it causes a significant medical burden. Drug resistant strains exist and they are especially prevalent in immunocompromised patients and in HSV eye infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb00cb1d7136925c3d36449e0c027777
http://juuli.fi/Record/0283718617
http://juuli.fi/Record/0283718617
Autor:
Nina Sipari, Liisa M. Lund, Kiira M. Kalke, Minna M. Poranen, Henrik Paavilainen, Veijo Hukkanen, Mohammadreza Sadeghi, Alesia A. Levanova, Marie C. Nyman
Publikováno v:
Antiviral Research
Chemical modifications of small interfering (si)RNAs are used to enhance their stability and potency, and to reduce possible off-target effects, including immunogenicity. We have earlier introduced highly effective antiviral siRNA swarms against herp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1c33ccf0fccd18792bd1a70205722a
https://doi.org/10.1016/j.antiviral.2020.104916
https://doi.org/10.1016/j.antiviral.2020.104916