Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Henriette S. Frislev"'
Publikováno v:
Frislev, H S, Nielsen, J, Nylandsted, J & Otzen, D 2018, ' Using Liprotides to Deliver Cholesterol to the Plasma Membrane ', Journal of Membrane Biology, vol. 25, no. 4, pp. 581-592 . https://doi.org/10.1007/s00232-018-0034-y
Cholesterol (chol) is important in all mammalian cells as a modulator of membrane fluidity. However, its low solubility is a challenge for controlled delivery to membranes. Here we introduce a new tool to deliver chol to membranes, namely, liprotides
Publikováno v:
Frislev, H S, Jakobsen, S C L, Frank, S A & Otzen, D E 2018, ' Dynamic content exchange between liprotides ', Biophysical Chemistry, vol. 233, pp. 13-18 . https://doi.org/10.1016/j.bpc.2017.11.006
Liprotides are complexes composed of partially denatured proteins and fatty acids in which the fatty acids form a micelle-like core surrounded by a shell of proteins. Liprotides, composed of α-lactalbumin (aLA) and oleic acid (OA), are similar in co
Publikováno v:
Pedersen, J N, Frislev, H K S, Pedersen, J S & Otzen, D 2020, ' Structures and mechanisms of formation of liprotides ', B B A-Proteins and Proteomics, vol. 1868, no. 11, 140505 . https://doi.org/10.1016/j.bbapap.2020.140505
Many proteins form complexes called liprotides with oleic acid and other cis-fatty acids under conditions where the protein is partially unfolded. The complexes vary in structure depending on the ratio of protein and lipid, but the most common struct
Publikováno v:
Scientific Reports
Frislev, H S, Boye, T L, Nylandsted, J & Otzen, D 2017, ' Liprotides kill cancer cells by disrupting the plasma membrane ', Scientific Reports, vol. 7, 15129 . https://doi.org/10.1038/s41598-017-15003-6
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Frislev, H S, Boye, T L, Nylandsted, J & Otzen, D 2017, ' Liprotides kill cancer cells by disrupting the plasma membrane ', Scientific Reports, vol. 7, 15129 . https://doi.org/10.1038/s41598-017-15003-6
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
HAMLET (human α-lactalbumin made lethal to tumour cells) is a complex of α-lactalbumin (aLA) and oleic acid (OA) which kills transformed cells, while leaving fully differentiated cells largely unaffected. Other protein-lipid complexes show similar
Publikováno v:
Pedersen, J N, Frislev, H K S, Pedersen, J S & Otzen, D E 2016, ' Using protein-fatty acid complexes to improve vitamin D stability ', Journal of Dairy Science, vol. 99, no. 10, pp. 7755–7767 . https://doi.org/10.3168/jds.2016-11343
Liprotides are complexes between lipids and partially denatured proteins in which the protein forms a stabilizing shell around a fatty acid micelle core. We have previously shown that liprotides stabilize small aliphatic molecules such as retinal and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5618dafb461447133adf285c0d915c18
https://pure.au.dk/portal/da/publications/using-proteinfatty-acid-complexes-to-improve-vitamin-d-stability(e5c964ae-9824-4622-8977-380d724822e8).html
https://pure.au.dk/portal/da/publications/using-proteinfatty-acid-complexes-to-improve-vitamin-d-stability(e5c964ae-9824-4622-8977-380d724822e8).html
Autor:
Christian Moestrup Jessen, Cristiano L. P. Oliveira, Henriette S. Frislev, Jan Skov Pedersen, Daniel E. Otzen
Publikováno v:
Frislev, H K S, Jessen, C M, Oliveira, C L P, Pedersen, J S & Otzen, D E 2016, ' Liprotides made of α-lactalbumin and cis fatty acids form core-shell and multi-layer structures with a common membrane-targeting mechanism ', B B A-Proteins and Proteomics, vol. 1864, no. 7, pp. 847-859 . https://doi.org/10.1016/j.bbapap.2016.04.003
α-Lactalbumin (aLA) has been shown to form complexes with oleic acid (OA), which may target cancer cells. We recently showed that aLA and several other proteins all form protein-OA complexes called liprotides with a generic structure consisting of a
Publikováno v:
ResearcherID
Pedersen, J N, Frislev, H K S, Pedersen, J S & Otzen, D 2016, ' Liprotides: a New Class of Protein Lipid-Complexes ', Los Angeles, United States, 27/02/2016-02/03/2016, . https://doi.org/10.1016/j.bpj.2015.11.3085
Pedersen, J N, Frislev, H K S, Pedersen, J S & Otzen, D 2016, ' Liprotides: a New Class of Protein Lipid-Complexes ', Los Angeles, United States, 27/02/2016-02/03/2016, . https://doi.org/10.1016/j.bpj.2015.11.3085
A cytotoxic complex between α-lactalbumin (aLA) and oleic acid (OA) has been investigated since the 1990's because of its anticancer activity [1]. Recently, many other complexes consisting of different proteins and fatty acids (which we term liproti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0cdd21d30352bfc834f9e1d8ec16b7
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375143000314&KeyUID=WOS:000375143000314
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375143000314&KeyUID=WOS:000375143000314
Publikováno v:
ResearcherID
Frislev, H K S, Pedersen, J N, Pedersen, J S & Otzen, D E 2016, ' Liprotides : Nano-Sized Cytotoxic Protein-Fatty Acid Complexes with a Core-Shell or Multi-Layer Structure ', Biophysical Journal, vol. 110, no. 3, pp. 577A . https://doi.org/10.1016/j.bpj.2015.11.3087
Frislev, H K S, Pedersen, J N, Pedersen, J S & Otzen, D E 2016, ' Liprotides : Nano-Sized Cytotoxic Protein-Fatty Acid Complexes with a Core-Shell or Multi-Layer Structure ', Biophysical Journal, vol. 110, no. 3, pp. 577A . https://doi.org/10.1016/j.bpj.2015.11.3087
A cytotoxic protein-fatty acid complex known as HAMLET is a complex which can target cancer cells. The complex discovered in 1995 is composed of the milk protein alpha-lactalbumin (aLA) and the cis-monounsaturated fatty acid, oleic acid (OA) [1]. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfc58a18cade25b915f716d3cd7a23d
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375143000316&KeyUID=WOS:000375143000316
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375143000316&KeyUID=WOS:000375143000316