Targeting glioma stem‐like cell survival and chemoresistance through inhibition of lysine‐specific histone demethylase KDM2B

Autor: Mikkel Staberg, Rikke Darling Rasmussen, Signe Regner Michaelsen, Henriette Pedersen, Kamilla Ellermann Jensen, Mette Villingshøj, Jane Skjoth‐Rasmussen, Jannick Brennum, Kristoffer Vitting‐Seerup, Hans Skovgaard Poulsen, Petra Hamerlik

Publikováno v: Molecular Oncology, Vol 12, Iss 3, Pp 406-420 (2018)

Glioblastoma (GBM) ranks among the most lethal cancers, with current therapies offering only palliation. Inter‐ and intrapatient heterogeneity is a hallmark of GBM, with epigenetically distinct cancer stem‐like cells (CSCs) at the apex. Targeting

Externí odkaz: https://doaj.org/article/398d29935a7f40d8aa830b02552b115b

Perspective: targeting VEGF-A and YKL-40 in glioblastoma – matter matters

Autor: Petra Hamerlik, Eva Løbner Lund, Kristoffer Vitting-Seerup, Elisabeth Anne Adanma Obara, Hans Skovgaard Poulsen, Jane Skjøth-Rasmussen, Henriette Pedersen, Julia S. Johansen, Kamilla E. Jensen, Camilla Bjørnbak Holst

Publikováno v: Cell Cycle
article-version (VoR) Version of Record
Holst, C B, Pedersen, H, Obara, E A A, Vitting-Seerup, K, Jensen, K E, Skjøth-Rasmussen, J, Lund, E L, Poulsen, H S, Johansen, J S & Hamerlik, P 2021, ' Perspective : targeting VEGF-A and YKL-40 in glioblastoma–matter matters ', Cell Cycle, vol. 20, no. 7, pp. 702-715 . https://doi.org/10.1080/15384101.2021.1901037

Glioblastomas (GBM) are heterogeneous highly vascular brain tumors exploiting the unique microenvironment in the brain to resist treatment and anti-tumor responses. Anti-angiogenic agents, immunotherapy, and targeted therapy have been studied extensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455c7e1e0ae71ee8c04676ce6038a836
http://europepmc.org/articles/PMC8078714

SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

Autor: Jannick Brennum, Jiri Bartek, Diana Aguilar-Morante, Petra Hamerlik, Elisabeth Anne Adanma Obara, Rikke Darling Rasmussen, Lucie Tučková, Alex Frias, Robert Strauss, Henriette Pedersen, Christoffel Dinant, Kirstine Juul Elbæk, Yi Chieh Lim, Kamilla E. Jensen, Kristoffer Vitting-Serup, Jane Skjøth-Rasmussen, Lina Vardouli

Publikováno v: Obara, E A A, Aguilar-Morante, D, Rasmussen, R D, Frias, A, Vitting-Serup, K, Lim, Y C, Elbæk, K J, Pedersen, H, Vardouli, L, Jensen, K E, Skjoth-Rasmussen, J, Brennum, J, Tuckova, L, Strauss, R, Dinant, C, Bartek, J & Hamerlik, P 2020, ' SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells ', Nature Communications, vol. 11, 4709 . https://doi.org/10.1038/s41467-020-18549-8
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for glioblastoma patients. Mechanisms underpinning radio-resistance of GSCs remain largely unknown. Chromatin state and the accessibil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7eccf9fad8a44a46aaf6c842ec456e
https://doi.org/10.1038/s41467-020-18549-8

Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B

Autor: Petra Hamerlik, Kristoffer Vitting-Seerup, Signe Regner Michaelsen, Jannick Brennum, Jane Skjøth-Rasmussen, Mikkel Staberg, Mette Villingshøj, Henriette Pedersen, Hans Skovgaard Poulsen, Kamilla E. Jensen, Rikke Darling Rasmussen

Publikováno v: Staberg, M, Rasmussen, R D, Michaelsen, S R, Pedersen, H, Jensen, K E, Villingshøj, M, Skjoth-Rasmussen, J, Brennum, J, Vitting-Seerup, K, Poulsen, H S & Hamerlik, P 2018, ' Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B ', Molecular Oncology, vol. 12, no. 3, pp. 406-420 . https://doi.org/10.1002/1878-0261.12174
Molecular Oncology
Molecular Oncology, Vol 12, Iss 3, Pp 406-420 (2018)

Glioblastoma (GBM) ranks among the most lethal cancers, with current therapies offering only palliation. Inter- and intrapatient heterogeneity is a hallmark of GBM, with epigenetically distinct cancer stem-like cells (CSCs) at the apex. Targeting GSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf53bff8bad4133394dfd6e7ad0716b2
https://doi.org/10.1002/1878-0261.12174

RDNA-14. IDENTIFICATION OF NOVEL RADIOSENSITIZERS IN GLIOBLASTOMA CANCER STEM-LIKE CELLS

Autor: Henriette Pedersen, Petra Hamerlik, Diana Aguilar-Morante, Elisabeth Anne Adanma Obara

Glioblastoma (GBM) is the most lethal primary brain malignancy characterized by rampant genomic instability, angiogenesis and intra- as well as inter-tumoral heterogeneity, albeit leading to therapeutic resistance. Substantial evidence has identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e531a6f78565e00bf62357159ba3b0
https://europepmc.org/articles/PMC6217521/