Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Henriette O'Geen"'
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
An extensive arsenal of biosensing tools has been developed based on the clustered regularly interspaced short palindromic repeat (CRISPR) platform, including those that detect specific DNA sequences both in vitro and in live cells. To date, DNA imag
Externí odkaz:
https://doaj.org/article/20d965019e1643b1abd364af6fdf42ec
Autor:
Peter Deng, Julian A. N. M. Halmai, Ulrika Beitnere, David Cameron, Michele L. Martinez, Charles C. Lee, Jennifer J. Waldo, Krista Thongphanh, Anna Adhikari, Nycole Copping, Stela P. Petkova, Ruth D. Lee, Samantha Lock, Miranda Palomares, Henriette O’Geen, Jasmine Carter, Casiana E. Gonzalez, Fiona K. B. Buchanan, Johnathan D. Anderson, Fernando A. Fierro, Jan A. Nolta, Alice F. Tarantal, Jill L. Silverman, David J. Segal, Kyle D. Fink
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
Zinc finger (ZF), transcription activator-like effectors (TALE), and CRISPR/Cas9 therapies to regulate gene expression are becoming viable strategies to treat genetic disorders, although effective in vivo delivery systems for these proteins remain a
Externí odkaz:
https://doaj.org/article/467d6e2aab3844e6b89d37a65f30a120
Autor:
Henriette O’Geen, Sofie L. Bates, Sakereh S. Carter, Karly A. Nisson, Julian Halmai, Kyle D. Fink, Suhn K. Rhie, Peggy J. Farnham, David J. Segal
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-20 (2019)
Abstract Background Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions.
Externí odkaz:
https://doaj.org/article/f99d86a8bbaf4fed912b9c90925d2dd9
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193818 (2018)
Prokaryotic Argonaute proteins (pAgos) have been proposed as an alternative to the CRISPR/Cas9 platform for gene editing. Although Argonaute from Natronobacterium gregoryi (NgAgo) was recently shown unable to cleave genomic DNA in mammalian cells, th
Externí odkaz:
https://doaj.org/article/5fe9074547764542bb6c960536bf0eff
Publikováno v:
BioTechniques, Vol 41, Iss 5, Pp 577-580 (2006)
A single chromatin immunoprecipitation (ChIP) sample does not provide enough DNA for hybridization to a genomic tiling array. A commonly used technique for amplifying the DNA obtained from ChIP assays is ligation-mediated PCR (LM-PCR). However, using
Externí odkaz:
https://doaj.org/article/7158a1050435478d91d69fb270e9de4d
Autor:
Kimberly R Blahnik, Lei Dou, Lorigail Echipare, Sushma Iyengar, Henriette O'Geen, Erica Sanchez, Yongjun Zhao, Marco A Marra, Martin Hirst, Joseph F Costello, Ian Korf, Peggy J Farnham
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17121 (2011)
The H3K9me3 histone modification is often found at promoter regions, where it functions to repress transcription. However, we have previously shown that 3' exons of zinc finger genes (ZNFs) are marked by high levels of H3K9me3. We have now further in
Externí odkaz:
https://doaj.org/article/bc6ab42b82fb4774b11be5e4eb7057e1
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15082 (2010)
Only a small percentage of human transcription factors (e.g. those associated with a specific differentiation program) are expressed in a given cell type. Thus, cell fate is mainly determined by cell type-specific silencing of transcription factors t
Externí odkaz:
https://doaj.org/article/e228ff23de144c23bd678f87016e3721
Autor:
Henriette O'Geen, Sharon L Squazzo, Sushma Iyengar, Kim Blahnik, John L Rinn, Howard Y Chang, Roland Green, Peggy J Farnham
Publikováno v:
PLoS Genetics, Vol 3, Iss 6, p e89 (2007)
We performed a genome-scale chromatin immunoprecipitation (ChIP)-chip comparison of two modifications (trimethylation of lysine 9 [H3me3K9] and trimethylation of lysine 27 [H3me3K27]) of histone H3 in Ntera2 testicular carcinoma cells and in three di
Externí odkaz:
https://doaj.org/article/6b4d600cd6c34b84ade4521f973cb5d7
Autor:
Henriette O’Geen, Ulrika Beitnere, Miranda S. Garcia, Anna Adhikari, David L. Cameron, Timothy A. Fenton, Nycole A. Copping, Peter Deng, Samantha Lock, Julian A.N.M. Halmai, Isaac J. Villegas, Jiajian Liu, Danhui Wang, Kyle D. Fink, Jill L. Silverman, David J. Segal
Publikováno v:
Molecular Therapy. 31:1088-1105
Autor:
Maxine Umeh-Garcia, Henriette O’Geen, Catalina Simion, Melanie Hayden Gephart, David J. Segal, Colleen A. Sweeney
Publikováno v:
British journal of cancer, vol 127, iss 3
Background LRIG1, the founding member of the LRIG (leucine-rich repeat and immunoglobulin-like domain) family of transmembrane proteins, is a negative regulator of receptor tyrosine kinases and a tumour suppressor. Decreased LRIG1 expression is consi