Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Henricus J. Broxterman"'
Autor:
Alan F. List, Rik J. Scheper, Steven N. Wolff, Henricus J. Broxterman, Cynthia Johnson, Thomas M. Grogan, John P. Greer, George L. Scheffer, Denise J. Roe, C. Spier, William S. Dalton
Publikováno v:
Blood. 87:2464-2469
The monoclonal antibody LRP56 recognizes a 110-kD major vault protein (lung-resistance protein [LRP]) overexpressed in several P-glycoprotein- negative (Pgp-), multidrug resistant tumor cell lines. To determine the frequency of LRP overexpression, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b10de95cdaab74ca433a49d707b43bbc
https://doi.org/10.1182/blood.v87.6.2464.bloodjournal8762464
https://doi.org/10.1182/blood.v87.6.2464.bloodjournal8762464
Autor:
Gerrit Jan Schuurhuis, Ellen C. Spoelstra, Henricus J. Broxterman, Jan Lankelma, Henk L. Dekker
Publikováno v:
Biochemical Pharmacology. 41:349-359
We studied the resistance of colon tumors to anticancer agents in vitro. Using daunorubicin (DN), a number of cellular parameters which normally indicate acquired or multidrug resistance (MDR), were compared for several human wild-type colon cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::043ac66cf62987eb244bc5fbd644a866
https://doi.org/10.1016/0006-2952(91)90531-9
https://doi.org/10.1016/0006-2952(91)90531-9
Publikováno v:
Biochimica et biophysica acta. 1055(3)
Using a flow-through system human multidrug-resistant 2780 AD ovarian carcinoma cells were exposed to flowing culture medium containing the anticancer agent daunomycin (5 μM). A pulse of medium containing verapamil caused increased cellular daunomyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f8e989256621046d692e64dd8f0cf2
https://pubmed.ncbi.nlm.nih.gov/1979920
https://pubmed.ncbi.nlm.nih.gov/1979920
Autor:
Gerrit J. Schuurhuis, Herbert M. Pinedo, Henricus J. Broxterman, Coenraad K. Van Kalken, Catharina M. Kuiper, Jan Lankelma
Publikováno v:
International journal of cancer. 46(2)
Calcium channel blockers, calmodulin inhibitors, and some other classes of non-related compounds reverse multi-drug resistance. In the present study, we found that several resistance modifiers are more toxic for MDR cells than for the corresponding s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260618247ace5e4109cbbfe8191c0069
https://pubmed.ncbi.nlm.nih.gov/2384279
https://pubmed.ncbi.nlm.nih.gov/2384279
Autor:
Henricus J. Broxterman, Lynne Richter, Thomas M. Grogan, Jenai M. Kailey, James A. Rybski, Herbert M. Pinedo, Rik J. Scheper, William S. Dalton, Sydney E. Salmon
Publikováno v:
Blood. 73:747-752
Using several multiple drug-resistant human myeloma cell lines as standards, we developed an immunohistochemical staining technique and means of quantitating P-glycoprotein in individual myeloma cells. The level of staining intensity for P-glycoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::378f05ef5ae8aabbaee6d3cf0e02e751
https://doi.org/10.1182/blood.v73.3.747.747
https://doi.org/10.1182/blood.v73.3.747.747
Autor:
Takashi Tsuruo, Henricus J. Broxterman, Jan Lankelma, Gerrit Jan Schuurhuis, Herbert M. Pinedo, C. M. Kuiper
Publikováno v:
Biochemical Pharmacology. 37:2389-2393
An overexpression of plasma membrane 170-180 kDa P-glycoproteins is consistently found in multidrug-resistant (MDR) cell lines. In this study MRK-16, a monoclonal antibody (mAb) reacting with P-glycoprotein is used to study the putative functional ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f717792adcbec7f73b9d1553b8a02c
https://doi.org/10.1016/0006-2952(88)90365-6
https://doi.org/10.1016/0006-2952(88)90365-6
Publikováno v:
FEBS Letters. (2):405-410
We show that drugs, such as verapamil, which reverse multidrug resistance (MDR), in P-glycoprotein-overexpressing tumor cells, increased the rate of lactate production in four human MDR cell lines, but not in the parent, sensitive cell lines. The eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6920d32cb031d0501767dc3c50c72ff
Autor:
Gerrit Jan Schuurhuis, Herbert M. Pinedo, Jan Lankelma, Henricus J. Broxterman, C. M. Kuiper, Lucia C. M. Kaptein
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2(7)
A marked increase in cellular ATP consumption was induced by verapamil in the multidrug-resistant (MDR) cell line 2780AD, but not in the drug-sensitive parental cell line A2780. A group of structurally unrelated drugs in concentrations known to rever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f41949043638d08ac92597210601fea
https://pubmed.ncbi.nlm.nih.gov/3350243
https://pubmed.ncbi.nlm.nih.gov/3350243